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Protein

Protein transport protein Sec23A

Gene

sec23a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincBy similarity1
Metal bindingi66ZincBy similarity1
Metal bindingi85ZincBy similarity1
Metal bindingi88ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cargo loading into COPII-coated vesicle Source: UniProtKB
  • cartilage development Source: ZFIN
  • embryonic neurocranium morphogenesis Source: ZFIN
  • intracellular protein transport Source: InterPro
  • pectoral fin morphogenesis Source: ZFIN

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-204005 COPII-mediated vesicle transport
R-DRE-5694530 Cargo concentration in the ER
R-DRE-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23ACurated
Alternative name(s):
SEC23-related protein A
Gene namesi
Name:sec23aBy similarity
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-040426-2823 sec23a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189341 – 765Protein transport protein Sec23AAdd BLAST765

Proteomic databases

PaxDbiQ7SZE5
PRIDEiQ7SZE5

Expressioni

Gene expression databases

BgeeiENSDARG00000104230
ExpressionAtlasiQ7SZE5 baseline and differential

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116386

Structurei

3D structure databases

ProteinModelPortaliQ7SZE5
SMRiQ7SZE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati632 – 718Gelsolin-likeSequence analysisAdd BLAST87

Domaini

The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs.By similarity

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
HOGENOMiHOG000231690
HOVERGENiHBG055039
InParanoidiQ7SZE5
KOiK14006
OMAiQVHEIGY
OrthoDBiEOG091G063R
PhylomeDBiQ7SZE5
TreeFamiTF300693

Family and domain databases

CDDicd11287 Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR037364 Sec23
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR037550 Sec23_C
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

Sequencei

Sequence statusi: Complete.

Q7SZE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFQEFIQQ NEDRDGVRFS WNVWPSSRLE ATRMVVPVAS LFTPLKERPD
60 70 80 90 100
LPPIQYEPVL CSRATCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG
110 120 130 140 150
ISEVNQPAEL LPQFSTIEYV VQRGPQMPLN FLYVVDTCME DDDLQALKES
160 170 180 190 200
LQMSLSLLPP TALVGLITFG RMVQVHELGC EGISKSYVFR GTKDLNAKQL
210 220 230 240 250
QEMLGLTKPA AAQAGRGPQQ PQVPPSNRFL QPVQKIDMNL TDLLGELQRD
260 270 280 290 300
PWPVTQGKRP LRSLGVALSI AVGLLECTFP NTGARIMAFI GGPATQGPGM
310 320 330 340 350
VVGDELKTPI RSWHDIEKDN AKFMKKATKH YEALANRAAA NGHIIDIYAC
360 370 380 390 400
ALDQTGLLEM KCCTNYTGGY MVMADSFNTS LFKQTFQRVF TKDVQGCFKM
410 420 430 440 450
ALAGTLEIKT SREIKISGAI GPCVSLNAKG PCVSENEMGT GGTSQWKICG
460 470 480 490 500
LDPNTTLGFY FEVVNQHNAP IPQGGRGAIQ YVTQYQHSSG QRRIRVTTIA
510 520 530 540 550
RNWADAQSQI QSIAASFDQE AAAILMARLA VYKAETEEGP DVLRWLDRQL
560 570 580 590 600
IRLCQKFGDY HKEDPNSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES
610 620 630 640 650
TYYRHQFMRQ DLTQSLIMVQ PILYAYSFNG PPEPVLLDSS SILPDRILLM
660 670 680 690 700
DTFFQILIYH GETVSQWRKA GYQDMPEYEN FRHLLQAPVD DAQELLHTRF
710 720 730 740 750
PMPRYIDTEH GGSQARFLLS KVNPSQTHNN MYAWGQESGA PILTDDVSLQ
760
VFMDHLKKLA VSSAA
Length:765
Mass (Da):86,080
Last modified:October 1, 2003 - v1
Checksum:i8059BDF16CD43059
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti580F → L in AAH97063 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052768 mRNA Translation: AAH52768.1
BC097063 mRNA Translation: AAH97063.1
RefSeqiNP_998630.1, NM_213465.1
UniGeneiDr.33071

Genome annotation databases

EnsembliENSDART00000160156; ENSDARP00000137308; ENSDARG00000104230
ENSDART00000168055; ENSDARP00000139718; ENSDARG00000104230
ENSDART00000169522; ENSDARP00000134628; ENSDARG00000104230
GeneIDi406774
KEGGidre:406774

Similar proteinsi

Entry informationi

Entry nameiSC23A_DANRE
AccessioniPrimary (citable) accession number: Q7SZE5
Secondary accession number(s): Q4V948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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