Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein transport protein Sec23A

Gene

sec23a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincBy similarity1
Metal bindingi66ZincBy similarity1
Metal bindingi85ZincBy similarity1
Metal bindingi88ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cargo loading into COPII-coated vesicle Source: UniProtKB
  • cartilage development Source: ZFIN
  • embryonic neurocranium morphogenesis Source: ZFIN
  • intracellular protein transport Source: InterPro
  • pectoral fin morphogenesis Source: ZFIN

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-DRE-2132295. MHC class II antigen presentation.
R-DRE-5694530. Cargo concentration in the ER.
R-DRE-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23ACurated
Alternative name(s):
SEC23-related protein A
Gene namesi
Name:sec23aBy similarity
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-040426-2823. sec23a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189341 – 765Protein transport protein Sec23AAdd BLAST765

Proteomic databases

PaxDbiQ7SZE5.
PRIDEiQ7SZE5.

Expressioni

Gene expression databases

BgeeiENSDARG00000104230.
ExpressionAtlasiQ7SZE5. baseline and differential.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116386.

Structurei

3D structure databases

ProteinModelPortaliQ7SZE5.
SMRiQ7SZE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati632 – 718Gelsolin-likeSequence analysisAdd BLAST87

Domaini

The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs.By similarity

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986. Eukaryota.
COG5047. LUCA.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ7SZE5.
KOiK14006.
OMAiCPFCLSR.
OrthoDBiEOG091G063R.
PhylomeDBiQ7SZE5.
TreeFamiTF300693.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
PfamiView protein in Pfam
PF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SZE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFQEFIQQ NEDRDGVRFS WNVWPSSRLE ATRMVVPVAS LFTPLKERPD
60 70 80 90 100
LPPIQYEPVL CSRATCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG
110 120 130 140 150
ISEVNQPAEL LPQFSTIEYV VQRGPQMPLN FLYVVDTCME DDDLQALKES
160 170 180 190 200
LQMSLSLLPP TALVGLITFG RMVQVHELGC EGISKSYVFR GTKDLNAKQL
210 220 230 240 250
QEMLGLTKPA AAQAGRGPQQ PQVPPSNRFL QPVQKIDMNL TDLLGELQRD
260 270 280 290 300
PWPVTQGKRP LRSLGVALSI AVGLLECTFP NTGARIMAFI GGPATQGPGM
310 320 330 340 350
VVGDELKTPI RSWHDIEKDN AKFMKKATKH YEALANRAAA NGHIIDIYAC
360 370 380 390 400
ALDQTGLLEM KCCTNYTGGY MVMADSFNTS LFKQTFQRVF TKDVQGCFKM
410 420 430 440 450
ALAGTLEIKT SREIKISGAI GPCVSLNAKG PCVSENEMGT GGTSQWKICG
460 470 480 490 500
LDPNTTLGFY FEVVNQHNAP IPQGGRGAIQ YVTQYQHSSG QRRIRVTTIA
510 520 530 540 550
RNWADAQSQI QSIAASFDQE AAAILMARLA VYKAETEEGP DVLRWLDRQL
560 570 580 590 600
IRLCQKFGDY HKEDPNSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES
610 620 630 640 650
TYYRHQFMRQ DLTQSLIMVQ PILYAYSFNG PPEPVLLDSS SILPDRILLM
660 670 680 690 700
DTFFQILIYH GETVSQWRKA GYQDMPEYEN FRHLLQAPVD DAQELLHTRF
710 720 730 740 750
PMPRYIDTEH GGSQARFLLS KVNPSQTHNN MYAWGQESGA PILTDDVSLQ
760
VFMDHLKKLA VSSAA
Length:765
Mass (Da):86,080
Last modified:October 1, 2003 - v1
Checksum:i8059BDF16CD43059
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti580F → L in AAH97063 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052768 mRNA. Translation: AAH52768.1.
BC097063 mRNA. Translation: AAH97063.1.
RefSeqiNP_998630.1. NM_213465.1.
UniGeneiDr.33071.

Genome annotation databases

EnsembliENSDART00000160156; ENSDARP00000137308; ENSDARG00000104230.
ENSDART00000168055; ENSDARP00000139718; ENSDARG00000104230.
ENSDART00000169522; ENSDARP00000134628; ENSDARG00000104230.
GeneIDi406774.
KEGGidre:406774.

Similar proteinsi

Entry informationi

Entry nameiSC23A_DANRE
AccessioniPrimary (citable) accession number: Q7SZE5
Secondary accession number(s): Q4V948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: September 27, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families