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Protein

Protein transport protein Sec23A

Gene

sec23a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cartilage development Source: ZFIN
  • embryonic neurocranium morphogenesis Source: ZFIN
  • ER to Golgi vesicle-mediated transport Source: InterPro
  • intracellular protein transport Source: InterPro
  • pectoral fin morphogenesis Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-DRE-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-DRE-2132295. MHC class II antigen presentation.
R-DRE-5694530. Cargo concentration in the ER.
R-DRE-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23A
Alternative name(s):
SEC23-related protein A
Gene namesi
Name:sec23a
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-040426-2823. sec23a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189341 – 765Protein transport protein Sec23AAdd BLAST765

Proteomic databases

PaxDbiQ7SZE5.
PRIDEiQ7SZE5.

Expressioni

Gene expression databases

BgeeiENSDARG00000016636.
ExpressionAtlasiQ7SZE5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116386.

Structurei

3D structure databases

ProteinModelPortaliQ7SZE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986. Eukaryota.
COG5047. LUCA.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ7SZE5.
KOiK14006.
OMAiWGESSAT.
OrthoDBiEOG091G063R.
PhylomeDBiQ7SZE5.
TreeFamiTF300693.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SZE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFQEFIQQ NEDRDGVRFS WNVWPSSRLE ATRMVVPVAS LFTPLKERPD
60 70 80 90 100
LPPIQYEPVL CSRATCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG
110 120 130 140 150
ISEVNQPAEL LPQFSTIEYV VQRGPQMPLN FLYVVDTCME DDDLQALKES
160 170 180 190 200
LQMSLSLLPP TALVGLITFG RMVQVHELGC EGISKSYVFR GTKDLNAKQL
210 220 230 240 250
QEMLGLTKPA AAQAGRGPQQ PQVPPSNRFL QPVQKIDMNL TDLLGELQRD
260 270 280 290 300
PWPVTQGKRP LRSLGVALSI AVGLLECTFP NTGARIMAFI GGPATQGPGM
310 320 330 340 350
VVGDELKTPI RSWHDIEKDN AKFMKKATKH YEALANRAAA NGHIIDIYAC
360 370 380 390 400
ALDQTGLLEM KCCTNYTGGY MVMADSFNTS LFKQTFQRVF TKDVQGCFKM
410 420 430 440 450
ALAGTLEIKT SREIKISGAI GPCVSLNAKG PCVSENEMGT GGTSQWKICG
460 470 480 490 500
LDPNTTLGFY FEVVNQHNAP IPQGGRGAIQ YVTQYQHSSG QRRIRVTTIA
510 520 530 540 550
RNWADAQSQI QSIAASFDQE AAAILMARLA VYKAETEEGP DVLRWLDRQL
560 570 580 590 600
IRLCQKFGDY HKEDPNSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES
610 620 630 640 650
TYYRHQFMRQ DLTQSLIMVQ PILYAYSFNG PPEPVLLDSS SILPDRILLM
660 670 680 690 700
DTFFQILIYH GETVSQWRKA GYQDMPEYEN FRHLLQAPVD DAQELLHTRF
710 720 730 740 750
PMPRYIDTEH GGSQARFLLS KVNPSQTHNN MYAWGQESGA PILTDDVSLQ
760
VFMDHLKKLA VSSAA
Length:765
Mass (Da):86,080
Last modified:October 1, 2003 - v1
Checksum:i8059BDF16CD43059
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti580F → L in AAH97063 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052768 mRNA. Translation: AAH52768.1.
BC097063 mRNA. Translation: AAH97063.1.
RefSeqiNP_998630.1. NM_213465.1.
UniGeneiDr.33071.

Genome annotation databases

EnsembliENSDART00000160156; ENSDARP00000137308; ENSDARG00000104230.
ENSDART00000168055; ENSDARP00000139718; ENSDARG00000104230.
ENSDART00000169522; ENSDARP00000134628; ENSDARG00000104230.
GeneIDi406774.
KEGGidre:406774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052768 mRNA. Translation: AAH52768.1.
BC097063 mRNA. Translation: AAH97063.1.
RefSeqiNP_998630.1. NM_213465.1.
UniGeneiDr.33071.

3D structure databases

ProteinModelPortaliQ7SZE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116386.

Proteomic databases

PaxDbiQ7SZE5.
PRIDEiQ7SZE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000160156; ENSDARP00000137308; ENSDARG00000104230.
ENSDART00000168055; ENSDARP00000139718; ENSDARG00000104230.
ENSDART00000169522; ENSDARP00000134628; ENSDARG00000104230.
GeneIDi406774.
KEGGidre:406774.

Organism-specific databases

CTDi10484.
ZFINiZDB-GENE-040426-2823. sec23a.

Phylogenomic databases

eggNOGiKOG1986. Eukaryota.
COG5047. LUCA.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ7SZE5.
KOiK14006.
OMAiWGESSAT.
OrthoDBiEOG091G063R.
PhylomeDBiQ7SZE5.
TreeFamiTF300693.

Enzyme and pathway databases

ReactomeiR-DRE-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-DRE-2132295. MHC class II antigen presentation.
R-DRE-5694530. Cargo concentration in the ER.
R-DRE-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

PROiQ7SZE5.

Gene expression databases

BgeeiENSDARG00000016636.
ExpressionAtlasiQ7SZE5. baseline and differential.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSC23A_DANRE
AccessioniPrimary (citable) accession number: Q7SZE5
Secondary accession number(s): Q4V948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.