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Q7SZC6

- RGS4_CHICK

UniProt

Q7SZC6 - RGS4_CHICK

Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 4
    Short name:
    RGS4
    Gene namesi
    Name:RGS4
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. plasma membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Regulator of G-protein signaling 4PRO_0000280761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21S-palmitoyl cysteineBy similarity
    Lipidationi12 – 121S-palmitoyl cysteineBy similarity
    Lipidationi95 – 951S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Palmitoylated on Cys-2 and/or Cys-12.By similarity
    Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiQ7SZC6.

    Expressioni

    Tissue specificityi

    Expressed in the developing nervous system.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ7SZC6.
    SMRiQ7SZC6. Positions 51-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 178117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG318241.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiQ7SZC6.
    KOiK16449.
    PhylomeDBiQ7SZC6.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SZC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCKGLAALPA TCLKSAKDMK HRLGVLLQKS DSCDYGSSQG KKEKVSSSQR    50
    VSQEEVKKWA ESLENLIHHD RGLAAFRAFL KSEYSEENIE FWVSCEDYKK 100
    TKSPAKLSTK ARKIYDEFIS VQATKEVNLD SCTREKTSHN MLEPTLSCFD 150
    EAQRKIFTLM EKDSYRRFLK SPYLDLVSPP RAGCGPENCK RAHAHALDCN 200
    SNIISQCA 208
    Length:208
    Mass (Da):23,523
    Last modified:October 1, 2003 - v1
    Checksum:i838B31750FF0EA68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY297457 mRNA. Translation: AAP57222.1.
    RefSeqiNP_989716.1. NM_204385.1.
    UniGeneiGga.5334.

    Genome annotation databases

    GeneIDi378901.
    KEGGigga:378901.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY297457 mRNA. Translation: AAP57222.1 .
    RefSeqi NP_989716.1. NM_204385.1.
    UniGenei Gga.5334.

    3D structure databases

    ProteinModelPortali Q7SZC6.
    SMRi Q7SZC6. Positions 51-178.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7SZC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 378901.
    KEGGi gga:378901.

    Organism-specific databases

    CTDi 5999.

    Phylogenomic databases

    eggNOGi NOG318241.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi Q7SZC6.
    KOi K16449.
    PhylomeDBi Q7SZC6.

    Miscellaneous databases

    NextBioi 20813871.
    PROi Q7SZC6.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b."
      Grillet N., Dubreuil V., Dufour H.D., Brunet J.-F.
      J. Neurosci. 23:10613-10621(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hindbrain.

    Entry informationi

    Entry nameiRGS4_CHICK
    AccessioniPrimary (citable) accession number: Q7SZC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3