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Q7SZC6

- RGS4_CHICK

UniProt

Q7SZC6 - RGS4_CHICK

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Protein
Regulator of G-protein signaling 4
Gene
RGS4
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGS4
Gene namesi
Name:RGS4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Regulator of G-protein signaling 4
PRO_0000280761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21S-palmitoyl cysteine By similarity
Lipidationi12 – 121S-palmitoyl cysteine By similarity
Lipidationi95 – 951S-palmitoyl cysteine By similarity

Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12 By similarity.
Phosphorylated by cyclic GMP-dependent protein kinase By similarity.

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ7SZC6.

Expressioni

Tissue specificityi

Expressed in the developing nervous system.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ7SZC6.
SMRiQ7SZC6. Positions 51-178.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 178117RGS
Add
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG318241.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ7SZC6.
KOiK16449.
PhylomeDBiQ7SZC6.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SZC6-1 [UniParc]FASTAAdd to Basket

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MCKGLAALPA TCLKSAKDMK HRLGVLLQKS DSCDYGSSQG KKEKVSSSQR    50
VSQEEVKKWA ESLENLIHHD RGLAAFRAFL KSEYSEENIE FWVSCEDYKK 100
TKSPAKLSTK ARKIYDEFIS VQATKEVNLD SCTREKTSHN MLEPTLSCFD 150
EAQRKIFTLM EKDSYRRFLK SPYLDLVSPP RAGCGPENCK RAHAHALDCN 200
SNIISQCA 208
Length:208
Mass (Da):23,523
Last modified:October 1, 2003 - v1
Checksum:i838B31750FF0EA68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY297457 mRNA. Translation: AAP57222.1.
RefSeqiNP_989716.1. NM_204385.1.
UniGeneiGga.5334.

Genome annotation databases

GeneIDi378901.
KEGGigga:378901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY297457 mRNA. Translation: AAP57222.1 .
RefSeqi NP_989716.1. NM_204385.1.
UniGenei Gga.5334.

3D structure databases

ProteinModelPortali Q7SZC6.
SMRi Q7SZC6. Positions 51-178.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7SZC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378901.
KEGGi gga:378901.

Organism-specific databases

CTDi 5999.

Phylogenomic databases

eggNOGi NOG318241.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi Q7SZC6.
KOi K16449.
PhylomeDBi Q7SZC6.

Miscellaneous databases

NextBioi 20813871.
PROi Q7SZC6.

Family and domain databases

Gene3Di 1.10.196.10. 1 hit.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b."
    Grillet N., Dubreuil V., Dufour H.D., Brunet J.-F.
    J. Neurosci. 23:10613-10621(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hindbrain.

Entry informationi

Entry nameiRGS4_CHICK
AccessioniPrimary (citable) accession number: Q7SZC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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