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Q7SZC6 (RGS4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 4

Short name=RGS4
Gene names
Name:RGS4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein By similarity.

Tissue specificity

Expressed in the developing nervous system. Ref.1

Post-translational modification

Palmitoylated on Cys-2 and/or Cys-12 By similarity.

Phosphorylated by cyclic GMP-dependent protein kinase By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Regulator of G-protein signaling 4
PRO_0000280761

Regions

Domain62 – 178117RGS

Amino acid modifications

Lipidation21S-palmitoyl cysteine By similarity
Lipidation121S-palmitoyl cysteine By similarity
Lipidation951S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7SZC6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 838B31750FF0EA68

FASTA20823,523
        10         20         30         40         50         60 
MCKGLAALPA TCLKSAKDMK HRLGVLLQKS DSCDYGSSQG KKEKVSSSQR VSQEEVKKWA 

        70         80         90        100        110        120 
ESLENLIHHD RGLAAFRAFL KSEYSEENIE FWVSCEDYKK TKSPAKLSTK ARKIYDEFIS 

       130        140        150        160        170        180 
VQATKEVNLD SCTREKTSHN MLEPTLSCFD EAQRKIFTLM EKDSYRRFLK SPYLDLVSPP 

       190        200 
RAGCGPENCK RAHAHALDCN SNIISQCA 

« Hide

References

[1]"Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b."
Grillet N., Dubreuil V., Dufour H.D., Brunet J.-F.
J. Neurosci. 23:10613-10621(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Hindbrain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY297457 mRNA. Translation: AAP57222.1.
RefSeqNP_989716.1. NM_204385.1.
UniGeneGga.5334.

3D structure databases

ProteinModelPortalQ7SZC6.
SMRQ7SZC6. Positions 51-178.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ7SZC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID378901.
KEGGgga:378901.

Organism-specific databases

CTD5999.

Phylogenomic databases

eggNOGNOG318241.
HOGENOMHOG000233512.
HOVERGENHBG013233.
InParanoidQ7SZC6.
KOK16449.
PhylomeDBQ7SZC6.

Family and domain databases

Gene3D1.10.196.10. 1 hit.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813871.
PROQ7SZC6.

Entry information

Entry nameRGS4_CHICK
AccessionPrimary (citable) accession number: Q7SZC6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families