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Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: GO_Central

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGS4
Gene namesi
Name:RGS4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. plasma membrane Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Regulator of G-protein signaling 4PRO_0000280761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21S-palmitoyl cysteineBy similarity
Lipidationi12 – 121S-palmitoyl cysteineBy similarity
Lipidationi95 – 951S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12.By similarity
Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ7SZC6.

Expressioni

Tissue specificityi

Expressed in the developing nervous system.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ7SZC6.
SMRiQ7SZC6. Positions 51-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 178117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG318241.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ7SZC6.
KOiK16449.
PhylomeDBiQ7SZC6.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SZC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKGLAALPA TCLKSAKDMK HRLGVLLQKS DSCDYGSSQG KKEKVSSSQR
60 70 80 90 100
VSQEEVKKWA ESLENLIHHD RGLAAFRAFL KSEYSEENIE FWVSCEDYKK
110 120 130 140 150
TKSPAKLSTK ARKIYDEFIS VQATKEVNLD SCTREKTSHN MLEPTLSCFD
160 170 180 190 200
EAQRKIFTLM EKDSYRRFLK SPYLDLVSPP RAGCGPENCK RAHAHALDCN

SNIISQCA
Length:208
Mass (Da):23,523
Last modified:October 1, 2003 - v1
Checksum:i838B31750FF0EA68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY297457 mRNA. Translation: AAP57222.1.
RefSeqiNP_989716.1. NM_204385.1.
UniGeneiGga.5334.

Genome annotation databases

GeneIDi378901.
KEGGigga:378901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY297457 mRNA. Translation: AAP57222.1.
RefSeqiNP_989716.1. NM_204385.1.
UniGeneiGga.5334.

3D structure databases

ProteinModelPortaliQ7SZC6.
SMRiQ7SZC6. Positions 51-178.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7SZC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378901.
KEGGigga:378901.

Organism-specific databases

CTDi5999.

Phylogenomic databases

eggNOGiNOG318241.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ7SZC6.
KOiK16449.
PhylomeDBiQ7SZC6.

Miscellaneous databases

NextBioi20813871.
PROiQ7SZC6.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b."
    Grillet N., Dubreuil V., Dufour H.D., Brunet J.-F.
    J. Neurosci. 23:10613-10621(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hindbrain.

Entry informationi

Entry nameiRGS4_CHICK
AccessioniPrimary (citable) accession number: Q7SZC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: February 4, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.