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Q7SZ10 (PP1GB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit B

Short name=PP-1G-B
Alternative name(s):
Protein phosphatase 1 zeta
Short name=xPP1-zeta
EC=3.1.3.16
Gene names
Name:ppp1cc-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis By similarity. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Subunit structure

PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits By similarity. UniProtKB P63088

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Cleavage furrow By similarity. Nucleusnucleolus By similarity. Nucleusnucleoplasm By similarity. Chromosomecentromerekinetochore By similarity. Nucleus speckle By similarity. Midbody By similarity. Mitochondrion By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Sequence caution

The sequence BAF51555.1 differs from that shown. Reason: Erroneous termination at position 249. Translated as Gln.

The sequence BAF51555.1 differs from that shown. Reason: Frameshift at position 301.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Serine/threonine-protein phosphatase PP1-gamma catalytic subunit B
PRO_0000365635

Sites

Active site1251Proton donor By similarity UniProtKB P36873
Metal binding641Manganese 1 By similarity UniProtKB P36873
Metal binding661Manganese 1 By similarity UniProtKB P36873
Metal binding921Manganese 1 By similarity UniProtKB P36873
Metal binding921Manganese 2 By similarity
Metal binding1241Manganese 2 By similarity UniProtKB P36873
Metal binding1731Manganese 2 By similarity UniProtKB P36873
Metal binding2481Manganese 2 By similarity UniProtKB P36873

Sequences

Sequence LengthMass (Da)Tools
Q7SZ10 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 38D4C5DE036A8C2D

FASTA32336,938
        10         20         30         40         50         60 
MADVDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK 

        70         80         90        100        110        120 
ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 

       130        140        150        160        170        180 
LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 

       190        200        210        220        230        240 
QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD 

       250        260        270        280        290        300 
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 

       310        320 
KKKPNASRPV TPPRGIITKQ AKK 

« Hide

References

« Hide 'large scale' references
[1]"Nuclear envelope precursor vesicle targeting to chromatin is stimulated by protein phosphatase 1 in Xenopus egg extracts."
Ito H., Koyama Y., Takano M., Ishii K., Maeno M., Furukawa K., Horigome T.
Exp. Cell Res. 313:1897-1910(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Oocyte.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tadpole.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB106882 mRNA. Translation: BAF51555.1. Sequence problems.
BC054188 mRNA. Translation: AAH54188.1.
RefSeqNP_001080904.1. NM_001087435.1.
UniGeneXl.83313.

3D structure databases

ProteinModelPortalQ7SZ10.
SMRQ7SZ10. Positions 6-300.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID380598.
KEGGxla:380598.

Organism-specific databases

CTD5501.

Phylogenomic databases

HOVERGENHBG000216.
KOK06269.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP1GB_XENLA
AccessionPrimary (citable) accession number: Q7SZ10
Secondary accession number(s): A4PB28
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families