Q7SYS9 (HNMTB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histamine N-methyltransferase B
Short name=HMT B
EC=2.1.1.8

Gene names

Name:

hnmt-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.
Catalytic activity	S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. HNMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histamine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Histamine N-methyltransferase B		PRO_0000271427
Sites
	Binding site	28	1	Substrate By similarity
	Binding site	60	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	89	1	S-adenosyl-L-methionine By similarity
	Binding site	94	1	S-adenosyl-L-methionine By similarity
	Binding site	120	1	S-adenosyl-L-methionine; via amide nitrogen By similarity
	Binding site	142	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	283	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SYS9 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: A9ACB64AA1F48BB3	FASTA	293	33,060
	10 20 30 40 50 60 MDSGLRSLLS DHSRYVESFR LFLQNSTEHQ CMQHFIETKL PDIISSIGND KPVIDVLGIG 70 80 90 100 110 120 SGSGEIDLQM IAKIQARWPG VSINNQIVEP SAEQILGYKE RVAKAPNLGY VTFSWHHQTS 130 140 150 160 170 180 SEFEHRVTED KQMTKYDFIH MIQMLYYVKD VPGTLKFFKS CLAPNGKLLI ILVSGNSGWA 190 200 210 220 230 240 PLWKKYGQRL PLNDLCLYVT AGDIAEMLSS MGARFQSHEL QSDMDITKCF IEGDKNGELL 250 260 270 280 290 LDFLTETCDF RKNAPAELRD QIICDLKSPR CSTTKDGKVI FNNNLSVIVV EAD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC054281 mRNA. Translation: AAH54281.1.
RefSeq	NP_001080614.1. NM_001087145.1.
UniGene	Xl.24624.
3D structure databases
HSSP	HSSP built from PDB template 2AOT based on UniProtKB P50135.
ProteinModelPortal	Q7SYS9.
SMR	Q7SYS9. Positions 5-292.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	380306.
KEGG	xla:380306.
Organism-specific databases
CTD	380306.
Xenbase	XB-GENE-6253788. hnmt.
Phylogenomic databases
HOVERGEN	HBG051914.
KO	K00546.
Family and domain databases
InterPro	IPR016673. Histamine_N-methyltransferase. [Graphical view]
PIRSF	PIRSF016616. HHMT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HNMTB_XENLA

Accession

Primary (citable) accession number: Q7SYS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 1, 2003
Last modified:	July 11, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program