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Protein

Cytosolic 5'-nucleotidase 3

Gene

nt5c3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Can act both as nucleotidase and as phosphotransferase.By similarity

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381NucleophileBy similarity
Metal bindingi38 – 381MagnesiumBy similarity
Active sitei40 – 401Proton donorBy similarity
Metal bindingi40 – 401Magnesium; via carbonyl oxygenBy similarity
Binding sitei85 – 851SubstrateBy similarity
Binding sitei106 – 1061SubstrateBy similarity
Binding sitei202 – 2021SubstrateBy similarity
Metal bindingi227 – 2271MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 5'-nucleotidase 3By similarity (EC:3.1.3.5By similarity)
Alternative name(s):
Cytosolic 5'-nucleotidase III
Short name:
cN-III
Gene namesi
Name:nt5c3
ORF Names:zgc:66117
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-439. nt5c3a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Cytosolic 5'-nucleotidase 3PRO_0000328952Add
BLAST

Proteomic databases

PaxDbiQ7SYN4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124389.

Structurei

3D structure databases

ProteinModelPortaliQ7SYN4.
SMRiQ7SYN4. Positions 1-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni153 – 1542Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pyrimidine 5'-nucleotidase family.Curated

Phylogenomic databases

eggNOGiKOG3128. Eukaryota.
ENOG410ZQJ8. LUCA.
HOGENOMiHOG000244931.
HOVERGENiHBG059750.
InParanoidiQ7SYN4.
KOiK01081.
PhylomeDBiQ7SYN4.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006434. Pyrimidine_nucleotidase_eu.
[Graphical view]
PfamiPF05822. UMPH-1. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01544. HAD-SF-IE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SYN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPEFEKNTV HIRDPERVEQ IICGLIKGGA SKLQIITDFD MTLSRFAVNG
60 70 80 90 100
KRCPSCHNII DNSKLVTDDC RKKLVHLKET YYPIEIDPHL TMEEKYPFMV
110 120 130 140 150
EWYFKSHTLL VEQRLEKDKL PEAVRESDVS LKEGYEQFFD RLHQHSVPVF
160 170 180 190 200
IFSAGLGDVL EEIIRQAGVY HPNVKVVSNF MDFDDNGVLK GFKGELIHVY
210 220 230 240 250
NKHDGALRNT EYFKQLKDNG NIILLGDSLG DLTMADGVPN VENILKIGYL
260 270 280
NDKVEELLEK YMDSYNIVLA RDETLEVPNS ILQKIL
Length:286
Mass (Da):32,937
Last modified:April 8, 2008 - v2
Checksum:iD738506E6B9DC4DF
GO

Sequence cautioni

The sequence AAH54650.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054650 mRNA. Translation: AAH54650.1. Different initiation.
RefSeqiNP_955854.1. NM_199560.1.
UniGeneiDr.150282.

Genome annotation databases

GeneIDi321720.
KEGGidre:321720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054650 mRNA. Translation: AAH54650.1. Different initiation.
RefSeqiNP_955854.1. NM_199560.1.
UniGeneiDr.150282.

3D structure databases

ProteinModelPortaliQ7SYN4.
SMRiQ7SYN4. Positions 1-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124389.

Proteomic databases

PaxDbiQ7SYN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi321720.
KEGGidre:321720.

Organism-specific databases

CTDi51251.
ZFINiZDB-GENE-030131-439. nt5c3a.

Phylogenomic databases

eggNOGiKOG3128. Eukaryota.
ENOG410ZQJ8. LUCA.
HOGENOMiHOG000244931.
HOVERGENiHBG059750.
InParanoidiQ7SYN4.
KOiK01081.
PhylomeDBiQ7SYN4.

Miscellaneous databases

PROiQ7SYN4.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006434. Pyrimidine_nucleotidase_eu.
[Graphical view]
PfamiPF05822. UMPH-1. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01544. HAD-SF-IE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry namei5NT3_DANRE
AccessioniPrimary (citable) accession number: Q7SYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.