Reviewed, UniProtKB/Swiss-Prot Q7SYN4 (5NT3L_DANRE)

Names and origin

Protein names

Recommended name:
    Cytosolic 5'-nucleotidase III-like protein
      Short name=cN-III-like protein
    EC=3.1.3.5

Gene names

Name:	nt5c3l
ORF Names:	zgc:66117

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can act both as nucleotidase and as phosphotransferase By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the pyrimidine 5'-nucleotidase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase Transferase
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Cytosolic 5'-nucleotidase III-like protein		PRO_0000328952
Regions
	Region	153 – 154	2	Substrate binding By similarity
Sites
	Active site	38	1	Nucleophile By similarity
	Active site	40	1	Proton donor By similarity
	Metal binding	38	1	Magnesium By similarity
	Metal binding	40	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	227	1	Magnesium By similarity
	Binding site	202	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SYN4-1 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: D738506E6B9DC4DF	FASTA	286	32,937
	10 20 30 40 50 60 MMPEFEKNTV HIRDPERVEQ IICGLIKGGA SKLQIITDFD MTLSRFAVNG KRCPSCHNII 70 80 90 100 110 120 DNSKLVTDDC RKKLVHLKET YYPIEIDPHL TMEEKYPFMV EWYFKSHTLL VEQRLEKDKL 130 140 150 160 170 180 PEAVRESDVS LKEGYEQFFD RLHQHSVPVF IFSAGLGDVL EEIIRQAGVY HPNVKVVSNF 190 200 210 220 230 240 MDFDDNGVLK GFKGELIHVY NKHDGALRNT EYFKQLKDNG NIILLGDSLG DLTMADGVPN 250 260 270 280 VENILKIGYL NDKVEELLEK YMDSYNIVLA RDETLEVPNS ILQKIL

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC054650 mRNA. Translation: AAH54650.1. Different initiation.
IPI	IPI00489455.
RefSeq	NP_955854.1.
UniGene	Dr.76855
3D structure databases
SMR	Q7SYN4. Positions 33-320.
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000058597. Danio rerio. [Contig view]
GeneID	321720.
KEGG	dre:321720.
Organism-specific databases
ZFIN	ZDB-GENE-030131-439. zgc:66117.
Phylogenomic databases
HOGENOM	Q7SYN4.
HOVERGEN	Q7SYN4.
Enzyme and pathway databases
BRENDA	3.1.3.5. 96826.
Gene expression databases
ArrayExpress	Q7SYN4.
Bgee	Q7SYN4.
Family and domain databases
InterPro	IPR006434. HAD-SF_hydro_IE. IPR018012. HAD-SF_hydro_IE_pln. [Graphical view]
PANTHER	PTHR13045. HAD-SF_hydro_IE. 1 hit.
Pfam	PF05822. UMPH-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01544. HAD-SF-IE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

5NT3L_DANRE

Accession

Primary (citable) accession number: Q7SYN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	June 16, 2009
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project