Reviewed, UniProtKB/Swiss-Prot Q7SYM0 (UCK2A_DANRE)

Names and origin

Protein names

Recommended name:
    Uridine-cytidine kinase 2-A
      Short name=UCK 2-A
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase 2-A
    Cytidine monophosphokinase 2-A

Gene names

Name:	uck2a
ORF Names:	si:ch211-216k22.2

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor By similarity.
Catalytic activity	ATP + uridine = ADP + UMP. ATP + cytidine = ADP + CMP.
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Uridine-cytidine kinase 2-A		PRO_0000346104
Regions
	Nucleotide binding	29 – 37	9	ATP By similarity
Sites
	Binding site	86	1	Substrate By similarity
	Binding site	114	1	Substrate By similarity
	Binding site	119	1	Substrate By similarity
	Binding site	168	1	Substrate By similarity
	Binding site	178	1	Substrate By similarity
	Binding site	186	1	Substrate By similarity
	Binding site	215	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SYM0-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 460C3C02A024490B	FASTA	261	29,628
	10 20 30 40 50 60 MAGDSDSKLD NHAENEHVDW QPFLIGVAGG TASGKSSVCG KIMELLGQNK IDHHQRQVAI 70 80 90 100 110 120 LSQDSFYRVL TPEQKAKALK GQFNFDHPDA FDNELIVKTL CEIMEGRTVQ IPVYDFVTHS 130 140 150 160 170 180 RKEETVTVYP ADVVLFEGIL MFYSQEIRDL FQMKLFVDTD ADTRLSRRVL RDISERGRDL 190 200 210 220 230 240 EQVLNQYITF VKPAFEEFCL PTKKYADVII PRGADNLVAI NLIVQHIQDF LNGGLTKRLN 250 260 GCLNGHTPRK RHPSESSSRP H

References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX927144 Genomic DNA. Translation: CAQ13314.1. BC054665 mRNA. Translation: AAH54665.1.
IPI	IPI00497830.
RefSeq	NP_956234.1. XP_001918844.1.
UniGene	Dr.116070
3D structure databases
SMR	Q7SYM0. Positions 21-233.
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000006074. Danio rerio. [Contig view]
GeneID	100005763. 335218.
KEGG	dre:100005763. dre:335218.
Organism-specific databases
ZFIN	ZDB-GENE-030131-7158. uck2a.
Phylogenomic databases
HOGENOM	Q7SYM0.
HOVERGEN	Q7SYM0.
OMA	Q7SYM0. GQNKIDH.
Gene expression databases
ArrayExpress	Q7SYM0.
Bgee	Q7SYM0.
Family and domain databases
InterPro	IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view]
PANTHER	PTHR10285:SF6. Uridine_kin. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UCK2A_DANRE

Accession

Primary (citable) accession number: Q7SYM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project