Reviewed,
UniProtKB/Swiss-Prot Q7SYM0 (UCK2A_DANRE)
Last modified
June 16, 2009.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Uridine-cytidine kinase 2-A Short name=UCK 2-A EC=2.7.1.48 Alternative name(s): Uridine monophosphokinase 2-A Cytidine monophosphokinase 2-A | ||||
| Gene names |
| ||||
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) | ||||
| Taxonomic identifier | 7955 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 261 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor By similarity. |
| Catalytic activity | ATP + uridine = ADP + UMP. ATP + cytidine = ADP + CMP. |
| Pathway | Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. |
| Sequence similarities | Belongs to the uridine kinase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptorInferred from electronic annotation. Source: InterPro uridine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 261 | 261 | Uridine-cytidine kinase 2-A | PRO_0000346104 | |||||
Regions | |||||||||
| Nucleotide binding | 29 – 37 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 86 | 1 | Substrate By similarity | ||||||
| Binding site | 114 | 1 | Substrate By similarity | ||||||
| Binding site | 119 | 1 | Substrate By similarity | ||||||
| Binding site | 168 | 1 | Substrate By similarity | ||||||
| Binding site | 178 | 1 | Substrate By similarity | ||||||
| Binding site | 186 | 1 | Substrate By similarity | ||||||
| Binding site | 215 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | The Danio rerio sequencing project at the Sanger Institute Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen. |
| [2] | NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB. |
Cross-references
Sequence databases | |
|---|---|
| BX927144 Genomic DNA. Translation: CAQ13314.1. BC054665 mRNA. Translation: AAH54665.1. | |
| IPI | IPI00497830. |
| RefSeq | NP_956234.1. XP_001918844.1. |
| UniGene | Dr.116070 |
3D structure databases | |
| SMR | Q7SYM0. Positions 21-233. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSDARG00000006074. Danio rerio. [Contig view] |
| GeneID | 100005763. 335218. |
| KEGG | dre:100005763. dre:335218. |
Organism-specific databases | |
| ZFIN | ZDB-GENE-030131-7158. uck2a. |
Phylogenomic databases | |
| HOGENOM | Q7SYM0. |
| HOVERGEN | Q7SYM0. |
| OMA | Q7SYM0. GQNKIDH. |
Gene expression databases | |
| ArrayExpress | Q7SYM0. |
| Bgee | Q7SYM0. |
Family and domain databases | |
| InterPro | IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view] |
| PANTHER | PTHR10285:SF6. Uridine_kin. 1 hit. |
| Pfam | PF00485. PRK. 1 hit. [Graphical view] |
| PRINTS | PR00988. URIDINKINASE. |
| TIGRFAMs | TIGR00235. udk. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UCK2A_DANRE | ||||||||
| Accession | Primary (citable) accession number: Q7SYM0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Zebrafish annotation project | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


