Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Monoacylglycerol lipase abhd6-B

Gene

abhd6-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481NucleophileBy similarity
Active sitei278 – 2781Charge relay systemBy similarity
Active sitei306 – 3061Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERixenla-Q7SY73. ABHD6-Lip.
MEROPSiS33.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase abhd6-BCurated (EC:3.1.1.23By similarity)
Alternative name(s):
Abhydrolase domain-containing protein 6-B
Gene namesi
Name:abhd6-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256516. abhd6.

Subcellular locationi

  • Membrane By similarity; Single-pass type II membrane protein Sequence analysis
  • Mitochondrion By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence analysisAdd
BLAST
Transmembranei20 – 4223Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini43 – 337295CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Monoacylglycerol lipase abhd6-BPRO_0000281579Add
BLAST

Proteomic databases

PRIDEiQ7SY73.

Structurei

3D structure databases

ProteinModelPortaliQ7SY73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG059524.
KOiK13700.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SY73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIDVLNMFL VAGGTLLVPL LAFMTSFLLW PAALIRIYYW YWRRALGMQV
60 70 80 90 100
KYSSYGNYKF CYTARGKPGN KPSVLMLHGF SAHKDMWLGM VKFLPKNLHL
110 120 130 140 150
VCVDMPGHEG TSRSALDYYS ICGQVKRIHQ FVESIGLNKK PFHLVGTSMG
160 170 180 190 200
GNVAGVYAAQ HPTHISSLTL ICPAGLMYPI ESKFLKQLKV LEKSGDNQRI
210 220 230 240 250
PLIPSTAGEM EDMLRLCSFV RFKIPQQVLQ GLIDERIPHN EFYRKLFLAL
260 270 280 290 300
VDEKSRHSLH ENMNKIMAPT QIIWGKQDQV LDVSGAEVLA GSLRGCQVEI
310 320 330
LENCGHSVVM ERPRKSAKLM TDFLSSLQST DNHKKHD
Length:337
Mass (Da):38,087
Last modified:October 1, 2003 - v1
Checksum:iD000221283D321FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054984 mRNA. Translation: AAH54984.1.
RefSeqiNP_001080850.1. NM_001087381.1.
UniGeneiXl.29371.

Genome annotation databases

GeneIDi380544.
KEGGixla:380544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054984 mRNA. Translation: AAH54984.1.
RefSeqiNP_001080850.1. NM_001087381.1.
UniGeneiXl.29371.

3D structure databases

ProteinModelPortaliQ7SY73.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERixenla-Q7SY73. ABHD6-Lip.
MEROPSiS33.977.

Proteomic databases

PRIDEiQ7SY73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi380544.
KEGGixla:380544.

Organism-specific databases

CTDi380544.
XenbaseiXB-GENE-6256516. abhd6.

Phylogenomic databases

HOVERGENiHBG059524.
KOiK13700.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Larva.

Entry informationi

Entry nameiABH6B_XENLA
AccessioniPrimary (citable) accession number: Q7SY73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: September 16, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.