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Protein

Ethanolamine-phosphate phospho-lyase

Gene

etnppl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.By similarity

Caution

Does not seem to possess aminotransferase activity.By similarity

Catalytic activityi

Ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate.

Cofactori

GO - Molecular functioni

GO - Biological processi

  • embryonic hemopoiesis Source: ZFIN

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DRE-1483213 Synthesis of PE

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine-phosphate phospho-lyase (EC:4.2.3.2)
Alternative name(s):
Alanine--glyoxylate aminotransferase 2-like 1
Gene namesi
Name:etnppl
Synonyms:agxt2l1
ORF Names:zgc:63486
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-040426-1133 etnppl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876651 – 492Ethanolamine-phosphate phospho-lyaseAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei280N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ7SY54

Expressioni

Gene expression databases

BgeeiENSDARG00000035544

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000051523

Structurei

3D structure databases

ProteinModelPortaliQ7SY54
SMRiQ7SY54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1403 Eukaryota
COG0160 LUCA
GeneTreeiENSGT00530000062907
HOGENOMiHOG000020206
HOVERGENiHBG004196
InParanoidiQ7SY54
KOiK14286
OMAiRVGNYLT
OrthoDBiEOG091G08ZM
PhylomeDBiQ7SY54
TreeFamiTF320468

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7SY54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATETLDKQK TIDLRKKHVG PSCKVFFDHD PIKIVRAKGQ YMYNEKDEKY
60 70 80 90 100
LDCINNVAHV GHCHPDVVSA GAKQMELLNT NSRFLHDSLV LYAQRLQATL
110 120 130 140 150
PEKLSVCYFV NSGSEANDLA LRLAWQYTGH KDIITLDNAY HGHVSSLIDI
160 170 180 190 200
SPYKFHQMAG AEPSQHVHVA LSPDTYRGKY REDHPDPATA YAENVKEVIE
210 220 230 240 250
EAHKKGHEIA AFIAESLQSC GGQVIPPMGY FQKVAQHVRN AGGIFIADEV
260 270 280 290 300
QVGFGRVGTH FWGFQLQGED FVPDIVTMGK PIGNGHPMSC VITSREIAES
310 320 330 340 350
FMSSGMEYFN TFGGNPVSCA IGLAVLNVIE KEDLQGNALH VGGYLTQLLE
360 370 380 390 400
DLKKRHPLVG DVRGRGLFVG LELVRNQSKR TPATAEAQEV IYRLKEQRIL
410 420 430 440 450
LSADGPHRNV LKFKPPMCFS REDAEFAVEK IDQILTDLEK AMVLQRPEAA
460 470 480 490
ILETGHIKRK DASDENGLVH PSNGNSHKHT STIPLSKKTK RN
Length:492
Mass (Da):54,735
Last modified:October 1, 2003 - v1
Checksum:iA95F48326640276E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055122 mRNA Translation: AAH55122.1
RefSeqiNP_956743.1, NM_200449.1
UniGeneiDr.106780

Genome annotation databases

EnsembliENSDART00000051524; ENSDARP00000051523; ENSDARG00000035544
GeneIDi393421
KEGGidre:393421

Similar proteinsi

Entry informationi

Entry nameiAT2L1_DANRE
AccessioniPrimary (citable) accession number: Q7SY54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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