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Protein

Ethanolamine-phosphate phospho-lyase

Gene

etnppl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.By similarity

Catalytic activityi

Ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate.

Cofactori

GO - Molecular functioni

GO - Biological processi

  • embryonic hemopoiesis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DRE-1483213. Synthesis of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine-phosphate phospho-lyase (EC:4.2.3.2)
Alternative name(s):
Alanine--glyoxylate aminotransferase 2-like 1
Gene namesi
Name:etnppl
Synonyms:agxt2l1
ORF Names:zgc:63486
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-040426-1133. etnppl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Ethanolamine-phosphate phospho-lyasePRO_0000287665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei280 – 2801N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ7SY54.

Expressioni

Gene expression databases

BgeeiQ7SY54.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000051523.

Structurei

3D structure databases

ProteinModelPortaliQ7SY54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1403. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ7SY54.
KOiK14286.
OMAiPYKFNQL.
OrthoDBiEOG79KPF2.
PhylomeDBiQ7SY54.
TreeFamiTF320468.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SY54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATETLDKQK TIDLRKKHVG PSCKVFFDHD PIKIVRAKGQ YMYNEKDEKY
60 70 80 90 100
LDCINNVAHV GHCHPDVVSA GAKQMELLNT NSRFLHDSLV LYAQRLQATL
110 120 130 140 150
PEKLSVCYFV NSGSEANDLA LRLAWQYTGH KDIITLDNAY HGHVSSLIDI
160 170 180 190 200
SPYKFHQMAG AEPSQHVHVA LSPDTYRGKY REDHPDPATA YAENVKEVIE
210 220 230 240 250
EAHKKGHEIA AFIAESLQSC GGQVIPPMGY FQKVAQHVRN AGGIFIADEV
260 270 280 290 300
QVGFGRVGTH FWGFQLQGED FVPDIVTMGK PIGNGHPMSC VITSREIAES
310 320 330 340 350
FMSSGMEYFN TFGGNPVSCA IGLAVLNVIE KEDLQGNALH VGGYLTQLLE
360 370 380 390 400
DLKKRHPLVG DVRGRGLFVG LELVRNQSKR TPATAEAQEV IYRLKEQRIL
410 420 430 440 450
LSADGPHRNV LKFKPPMCFS REDAEFAVEK IDQILTDLEK AMVLQRPEAA
460 470 480 490
ILETGHIKRK DASDENGLVH PSNGNSHKHT STIPLSKKTK RN
Length:492
Mass (Da):54,735
Last modified:October 1, 2003 - v1
Checksum:iA95F48326640276E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055122 mRNA. Translation: AAH55122.1.
RefSeqiNP_956743.1. NM_200449.1.
UniGeneiDr.106780.

Genome annotation databases

EnsembliENSDART00000051524; ENSDARP00000051523; ENSDARG00000035544.
GeneIDi393421.
KEGGidre:393421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055122 mRNA. Translation: AAH55122.1.
RefSeqiNP_956743.1. NM_200449.1.
UniGeneiDr.106780.

3D structure databases

ProteinModelPortaliQ7SY54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000051523.

Proteomic databases

PaxDbiQ7SY54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000051524; ENSDARP00000051523; ENSDARG00000035544.
GeneIDi393421.
KEGGidre:393421.

Organism-specific databases

CTDi64850.
ZFINiZDB-GENE-040426-1133. etnppl.

Phylogenomic databases

eggNOGiKOG1403. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ7SY54.
KOiK14286.
OMAiPYKFNQL.
OrthoDBiEOG79KPF2.
PhylomeDBiQ7SY54.
TreeFamiTF320468.

Enzyme and pathway databases

ReactomeiR-DRE-1483213. Synthesis of PE.

Miscellaneous databases

NextBioi20814460.
PROiQ7SY54.

Gene expression databases

BgeeiQ7SY54.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiAT2L1_DANRE
AccessioniPrimary (citable) accession number: Q7SY54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.