Reviewed, UniProtKB/Swiss-Prot Q7SY53 (T23OL_DANRE)

Names and origin

Protein names

Recommended name:
    Tryptophan 2,3-dioxygenase-like
      Short name=TO
    EC=1.13.11.11
Alternative name(s):
    Tryptophan pyrrolase
      Short name=Tryptophanase
    Tryptophan oxygenase
    Tryptamin 2,3-dioxygenase
      Short name=TRPO

Gene names

Name:	tdo2l
Synonyms:	tdo2
ORF Names:	zgc:63488

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-tryptophan + O(2) = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer. The hemes are protoheme IV By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro tryptophan catabolic process to kynurenine Inferred from electronic annotation. Source: InterPro
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro tryptophan 2,3-dioxygenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Tryptophan 2,3-dioxygenase-like		PRO_0000247475

Sequences

	Sequence		Length	Mass (Da)
	Q7SY53-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8EA9740C0D4F3912	FASTA	407	47,422
	10 20 30 40 50 60 MSGCPFLGGT LQLLSSNPRQ AEEEDGSQGG VNKAAKGGII YGDYLQLDKV LNAQVLQSEQ 70 80 90 100 110 120 KGNKIHDEHL FIVTHQAYEL WFKQILWELD SVRDLFIKKH VRDERNMLKV VSRIHRITMI 130 140 150 160 170 180 FKLLVDQFAV LETMTALDFF DFREYLSPAS GFQSLQFRLL EQKIGVADHL RVPYNRRHYR 190 200 210 220 230 240 DNFHGEESET LLSSEQEPTL LQLVEQWLER TPGLEKDGFN FWGKLQANIE EGLKREKHQV 250 260 270 280 290 300 EKMEDTEVKQ ELLEDLNKQM ETFTALFDSK RHEHLLSKGE RRLSYKALQG ALMINFYREE 310 320 330 340 350 360 PRFQVPFQLL TALMEIDTLM TKWRYNHVCM VHRMIGSKAG TGGSSGYHYL RSTVSDRYKV 370 380 390 400 FVDLFNLATF LVPRSWVPKL NPNIHKFPYT AECYDSSYNS CSSEDSD

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC055123 mRNA. Translation: AAH55123.1.
RefSeq	NP_956150.1.
UniGene	Dr.80748
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000023176. Danio rerio. [Contig view]
GeneID	334082.
KEGG	dre:334082.
Organism-specific databases
ZFIN	ZDB-GENE-030131-6014. tdo2l.
Phylogenomic databases
HOGENOM	Q7SY53.
HOVERGEN	Q7SY53.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23OL_DANRE

Accession

Primary (citable) accession number: Q7SY53

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 1, 2003
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project