Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q7SY23 (AL4A1_DANRE)

Last modified November 25, 2008. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
      Short name=P5C dehydrogenase
    EC=1.5.1.12
Alternative name(s):
    Aldehyde dehydrogenase family 4 member A1
Gene names
Name: aldh4a1
ORF Names: zgc:63592
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles By similarity.

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.

Subcellular location

Mitochondrion matrixBy similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords

   Biological processProline metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

proline biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: InterPro

   Molecular function1-pyrroline-5-carboxylate dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1717Mitochondrion By similarity
Chain18 – 556539Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
PRO_0000007175

Regions

Nucleotide binding289 – 2946NAD By similarity

Sites

Active site3071 By similarity
Active site3411 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7SY23-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: E7973E9787CEA358

FASTA55661,587
        10         20         30         40         50         60 
MLRARSAVSQ SWKGFKTFSC VAVEVKNEPV LEFKEGSKER AELEEALRNL KGKTEEIPCV 

        70         80         90        100        110        120 
IGNEEVWTKD IRFQLSPFNH SHQVAKFCYA DKDLLNKAIE ASVAARREWD LKPVSDRAQI 

       130        140        150        160        170        180 
FFKAADIISG PKRAEVLAKT MIGQGKTVVQ AEIDAAPELI DFFRFNAKHA IELEDQQPLD 

       190        200        210        220        230        240 
SDGSTNTMLY RGLEGFVAAV APFNFTAIGG NLAGTPALMG NVVLWKPSDT AMSASYAVYK 

       250        260        270        280        290        300 
ILRESGLPPN IIQFVPADGP VFGDTVTSSE HLAGINFTGS VPTFKRLWKQ VAQNLDIYKN 

       310        320        330        340        350        360 
FPRVAGECGG KNFHFVHKSA DVRSVVTGTI RSAFEYGGQK CSACSRMYVP DSLWPQIRQG 

       370        380        390        400        410        420 
LLDVYKQIKV GDPVEDFSTF FSAVIDDKSF SRIKGWLEHA RSSPHLKIIA GGNCDDKKGY 

       430        440        450        460        470        480 
FVEPTIIETT DPQEKIMNEE IFGPVLTVYV YPENDYKKVL HLIDNTSPYA LTGAIFPQDK 

       490        500        510        520        530        540 
SVIEEAGKAL RNAAGNYYIN DKSTGSIVAQ QPFGGARASG TNDKPGGPHY VLRWTSPQVV 

       550 
KQTHVPLTEW KYPYMS 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: SJD.

Cross-references

Sequence databases

BC055155 mRNA. Translation: AAH55155.1.
RefSeqNP_957452.1.
UniGeneDr.84922

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSDARG00000038207. Danio rerio. [Contig view]
GeneID394133.
KEGGdre:394133.

Organism-specific databases

ZFINZDB-GENE-040426-1179. aldh4a1.

Phylogenomic databases

HOGENOMQ7SY23.
HOVERGENQ7SY23.

Gene expression databases

ArrayExpressQ7SY23.

Family and domain databases

InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR015590. Aldehyde_DHase.
IPR005931. d-1-pyrroline-5-COlate_DHase-1.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01236. D1pyr5carbox1. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL4A1_DANRE
AccessionPrimary (citable) accession number: Q7SY23
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents