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Protein

GPI mannosyltransferase 3

Gene

pigb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 3 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase III
Short name:
GPI-MT-III
Phosphatidylinositol-glycan biosynthesis class B protein
Short name:
PIG-B
Gene namesi
Name:pigb
ORF Names:zgc:63658
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1216. pigb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002462531 – 536GPI mannosyltransferase 3Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7SXZ1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000032121.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1771. Eukaryota.
ENOG410XYK9. LUCA.
HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ7SXZ1.
KOiK05286.
PhylomeDBiQ7SXZ1.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SXZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIRERFKQ SKSSNESVRL RKRSSILYST DDRKLQTLKI FGINITVFIV
60 70 80 90 100
LVRLLNCVLV QTSFVPDEFW QSLEISHRMV FGYGYETWEW KEGIRGYSYP
110 120 130 140 150
LLFALMYKLL QLISYDTVYL LVFVPRVFQA LLAAYADVKL YKLILQWETP
160 170 180 190 200
DVAKWTCFCQ LCSWFAWFCC SRTLTNTTET ALTTLALCFY PLPGSKTHSS
210 220 230 240 250
WKYLTLVSLA VVIRPTALIV WFPLIFYHFC TDQDKLKLIT HRYFPIGVLA
260 270 280 290 300
LGVSTLIDSF FYGKWIFVQW NFLKFNVLHN VGEFYGSHPW HWYWTQGLPV
310 320 330 340 350
VIGPHLPLVL HGCLLSTRKH TILLLTIIWT TAVYSLLAHK EFRFIYPVLP
360 370 380 390 400
FCMIFCGLSL AKLQAWRKAA AGALLLFNLC PALYTGLVHQ RGALDVMHVL
410 420 430 440 450
QPLCVSSQSP NPPELLFLMP CHSTPLYSHL HCPLKLRFLE CPPDLTGRQD
460 470 480 490 500
YMDEADVFFS DPLHWLNTSF PLRSTLPSHL VLFDSLQKEI SSFLEENSFA
510 520 530
KQAEIFHTHF PEGRVGKNIL IYSRRSEMKI NEGFIL
Length:536
Mass (Da):62,240
Last modified:October 1, 2003 - v1
Checksum:iB16C0394921DE814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055191 mRNA. Translation: AAH55191.1.
RefSeqiNP_956770.1. NM_200476.1.
UniGeneiDr.17204.

Genome annotation databases

GeneIDi393448.
KEGGidre:393448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055191 mRNA. Translation: AAH55191.1.
RefSeqiNP_956770.1. NM_200476.1.
UniGeneiDr.17204.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000032121.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Proteomic databases

PaxDbiQ7SXZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393448.
KEGGidre:393448.

Organism-specific databases

CTDi9488.
ZFINiZDB-GENE-040426-1216. pigb.

Phylogenomic databases

eggNOGiKOG1771. Eukaryota.
ENOG410XYK9. LUCA.
HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ7SXZ1.
KOiK05286.
PhylomeDBiQ7SXZ1.

Enzyme and pathway databases

UniPathwayiUPA00196.

Miscellaneous databases

PROiQ7SXZ1.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGB_DANRE
AccessioniPrimary (citable) accession number: Q7SXZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.