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Protein

Solute carrier family 25 member 39

Gene

slc25a39

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the early steps of heme biosynthesis or in the regulation of delta-aminolevulinic acid synthase function.1 Publication

GO - Molecular functioni

  • metallochaperone activity Source: ZFIN

GO - Biological processi

  • heme biosynthetic process Source: ZFIN
  • manganese ion transport Source: ZFIN
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 39
Gene namesi
ORF Names:zgc:63736
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1250. slc25a39.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei120 – 140Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei163 – 183Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei213 – 233Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei254 – 274Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei317 – 337Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown of the protein results in profound anemia without affecting erythroid specification. No porphyric phenotype detected.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003866521 – 359Solute carrier family 25 member 39Add BLAST359

Proteomic databases

PaxDbiQ7SXW0.
PRIDEiQ7SXW0.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005911.

Structurei

3D structure databases

ProteinModelPortaliQ7SXW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 149Solcar 1Add BLAST137
Repeati157 – 241Solcar 2Add BLAST85
Repeati251 – 346Solcar 3Add BLAST96

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
HOGENOMiHOG000214473.
InParanoidiQ7SXW0.
KOiK15119.
PhylomeDBiQ7SXW0.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SXW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRPAVRIS AAITPVQQML ASGTGAVLTS LFVTPLDVVK IRLQAQQTPL
60 70 80 90 100
FQAIAAESRP WFRVTRPSKW KCFLYCNGLM DHVYVCQNMS SCSNLYKTST
110 120 130 140 150
HFSGTLDAFV KITHNEGLRS LWSGLPPTLV MAVPATVIYF TCYDQLRDFL
160 170 180 190 200
CYSMGYHGDH IPLIAGGLAR LGAVSVISPL ELVRTKMQSR RLQYSELMVC
210 220 230 240 250
IRSSVAQDGW LSLWRGWGPT VLRDVPFSAL YWFNYELVKA QLCEHYRTPQ
260 270 280 290 300
ASFTISFTAG AVSGAIAAVL TLPFDVVKTR RQIQLGEMEA LGAVSMKKPS
310 320 330 340 350
STWNMMRNIW IDMGYKGLFA GFLPRVIKVA PACAVMISTY EFGKTFFQER

NLHQARCGL
Length:359
Mass (Da):40,113
Last modified:October 1, 2003 - v1
Checksum:iA052E9F544B6D1E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055226 mRNA. Translation: AAH55226.1.
RefSeqiNP_956780.1. NM_200486.1.
UniGeneiDr.132778.

Genome annotation databases

GeneIDi393458.
KEGGidre:393458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055226 mRNA. Translation: AAH55226.1.
RefSeqiNP_956780.1. NM_200486.1.
UniGeneiDr.132778.

3D structure databases

ProteinModelPortaliQ7SXW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005911.

Proteomic databases

PaxDbiQ7SXW0.
PRIDEiQ7SXW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393458.
KEGGidre:393458.

Organism-specific databases

CTDi51629.
ZFINiZDB-GENE-040426-1250. slc25a39.

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
HOGENOMiHOG000214473.
InParanoidiQ7SXW0.
KOiK15119.
PhylomeDBiQ7SXW0.

Miscellaneous databases

PROiQ7SXW0.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2539_DANRE
AccessioniPrimary (citable) accession number: Q7SXW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.