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Protein

Macrophage erythroblast attacher

Gene

maea

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a possible role in erythroblast and macrophages maturation. May associate with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage erythroblast attacher
Gene namesi
Name:maea
ORF Names:zgc:63708
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-030131-294 maea

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849421 – 396Macrophage erythroblast attacherAdd BLAST396

Proteomic databases

PaxDbiQ7SXR3
PRIDEiQ7SXR3

Expressioni

Gene expression databases

BgeeiENSDARG00000053691

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000070240

Structurei

3D structure databases

SMRiQ7SXR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 153LisHPROSITE-ProRule annotationAdd BLAST33
Domaini159 – 216CTLHPROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiKOG0396 Eukaryota
ENOG410XPGU LUCA
GeneTreeiENSGT00720000108841
HOGENOMiHOG000241232
HOVERGENiHBG053270
InParanoidiQ7SXR3
KOiK18624
OMAiYAHHTKS
OrthoDBiEOG091G0E8J
PhylomeDBiQ7SXR3
TreeFamiTF314273

Family and domain databases

InterProiView protein in InterPro
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR027714 Fyv10/EMP
IPR006594 LisH
PANTHERiPTHR12170:SF2 PTHR12170:SF2, 1 hit
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequencei

Sequence statusi: Complete.

Q7SXR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQETAAQL SMALKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV
60 70 80 90 100
VAELEKTLSS FPVVDTVVSL LDGVVEKLSA LKRKAAESIQ AEDESAKLCK
110 120 130 140 150
RRIEHLKEHS SDQPASVNVW KKKRMDRMMV EHLLRCGYYN TAVKLARQSG
160 170 180 190 200
IEDLVNIEMF LTAKEVEESL ERQETATCLA WCHDNKSRLR KMKSCLEFSL
210 220 230 240 250
RIQEFIELIR QNKRMDAVRH ARKHFSQAEG GQLDEVRQVM GMLAFPSDTH
260 270 280 290 300
ISPYKDLLDP ARWKMLIQQF RYDNYRLHQL GNNSVFTITL QAGLSAIKTP
310 320 330 340 350
QCYKEDGTSK NPDCPVCSKS LNKLAQPLPM AHCANSRLVC KISGEVMNEN
360 370 380 390
NPPMMLPNGY VYGYNSLLSI RQDDKVICPR TKEVFNFSQA EKVYIM
Length:396
Mass (Da):45,342
Last modified:May 1, 2007 - v2
Checksum:iFCE3489C2E82C7B8
GO

Sequence cautioni

The sequence AAH55388 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055388 mRNA Translation: AAH55388.1 Different initiation.
RefSeqiNP_955843.2, NM_199549.2
UniGeneiDr.77238

Genome annotation databases

EnsembliENSDART00000075759; ENSDARP00000070240; ENSDARG00000053691
GeneIDi321575
KEGGidre:321575

Similar proteinsi

Entry informationi

Entry nameiMAEA_DANRE
AccessioniPrimary (citable) accession number: Q7SXR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health