Q7SXP8 (GMPAB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase alpha-B
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase A-B
GTP-mannose-1-phosphate guanylyltransferase apha-B

Gene names

Name:	gmppab
ORF Names:	zgc:66135

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Mannose-1-phosphate guanyltransferase alpha-B		PRO_0000327877

Sequences

	Sequence		Length	Mass (Da)
	Q7SXP8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 78090F1CE2D03698	FASTA	422	47,008
	10 20 30 40 50 60 MLKAIILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMLQHH IEACAQVPDM KEIMLIGFYQ 70 80 90 100 110 120 PNDELNRFIY SAQQEFKIPI RYLQEFAALG TGGGIYHFRD QILSGGPAAF FLMNADVCSE 130 140 150 160 170 180 FPLLEMLQFH RQHGENHCGV LLGTTANRTQ SLNYGCIVEN HETNEVLHFV EKPSTFVSDI 190 200 210 220 230 240 INCGIYLFTP DIFAHIGKVF QRNQQEKIQE ELTHGRQMPE VVRLEQDIFT ALAGQKKLFV 250 260 270 280 290 300 YKTQHFWSQI KSAGSAIYAS RLYLKQYHQT HPERLATNQG GTPKITGDVY IHPTANIDPS 310 320 330 340 350 360 AVLGPNVSIG KGVTIGGGVR VRESIILHGA VLQDHCCVLN SIVGWDSTVG KWARVEGTPS 370 380 390 400 410 420 DPNPNDPYAK IDSETLFRDG GLTPSITILG CNVNIPSEVI IRNSIVLPHK DLNRSFKNQI IL

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC055506 mRNA. Translation: AAH55506.1.
IPI	IPI00482677.
RefSeq	NP_956791.1. NM_200497.1.
UniGene	Dr.82480.
3D structure databases
ProteinModelPortal	Q7SXP8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	393469.
KEGG	dre:393469.
Organism-specific databases
CTD	393469.
ZFIN	ZDB-GENE-040426-1550. gmppab.
Phylogenomic databases
eggNOG	fiNOG04657.
GeneTree	ENSGT00530000063581.
HOGENOM	HBG688195.
HOVERGEN	HBG059531.
InParanoid	Q7SXP8.
OrthoDB	EOG4SXNCG.
PhylomeDB	Q7SXP8.
Gene expression databases
ArrayExpress	Q7SXP8.
Bgee	Q7SXP8.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPAB_DANRE

Accession

Primary (citable) accession number: Q7SXP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 1, 2003
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program