Reviewed, UniProtKB/Swiss-Prot Q7SXP8 (GMPAB_DANRE)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase alpha-B
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase apha-B
    GDP-mannose pyrophosphorylase A-B

Gene names

Name:	gmppab
ORF Names:	zgc:66135

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Mannose-1-phosphate guanyltransferase alpha-B		PRO_0000327877

Sequences

	Sequence		Length	Mass (Da)
	Q7SXP8-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 78090F1CE2D03698	FASTA	422	47,008
	10 20 30 40 50 60 MLKAIILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMLQHH IEACAQVPDM KEIMLIGFYQ 70 80 90 100 110 120 PNDELNRFIY SAQQEFKIPI RYLQEFAALG TGGGIYHFRD QILSGGPAAF FLMNADVCSE 130 140 150 160 170 180 FPLLEMLQFH RQHGENHCGV LLGTTANRTQ SLNYGCIVEN HETNEVLHFV EKPSTFVSDI 190 200 210 220 230 240 INCGIYLFTP DIFAHIGKVF QRNQQEKIQE ELTHGRQMPE VVRLEQDIFT ALAGQKKLFV 250 260 270 280 290 300 YKTQHFWSQI KSAGSAIYAS RLYLKQYHQT HPERLATNQG GTPKITGDVY IHPTANIDPS 310 320 330 340 350 360 AVLGPNVSIG KGVTIGGGVR VRESIILHGA VLQDHCCVLN SIVGWDSTVG KWARVEGTPS 370 380 390 400 410 420 DPNPNDPYAK IDSETLFRDG GLTPSITILG CNVNIPSEVI IRNSIVLPHK DLNRSFKNQI IL

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC055506 mRNA. Translation: AAH55506.1.
IPI	IPI00482677.
RefSeq	NP_956791.1.
UniGene	Dr.82480
3D structure databases
HSSP	HSSP built from PDB template 1G95 based on UniProtKB Q97R46.
ModBase	Search...
Genome annotation databases
Ensembl	ENSDART00000032331; ENSDARP00000032669; ENSDARG00000023498; Danio rerio. [Genome view]
GeneID	393469.
KEGG	dre:393469.
Organism-specific databases
ZFIN	ZDB-GENE-040426-1550. zgc:66135.
Phylogenomic databases
HOGENOM	Q7SXP8.
HOVERGEN	Q7SXP8.
Enzyme and pathway databases
BRENDA	2.7.7.13. 96826.
Gene expression databases
ArrayExpress	Q7SXP8.
Bgee	Q7SXP8.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPAB_DANRE

Accession

Primary (citable) accession number: Q7SXP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 1, 2003
Last modified:	September 22, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project