Reviewed, UniProtKB/Swiss-Prot Q7SXN5 (DNM1L_DANRE)

Names and origin

Protein names

Recommended name:
    Dynamin-1-like protein
    EC=3.6.5.5

Gene names

Name:	dnm1l
ORF Names:	zgc:66163

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Enzyme hydrolyzing GTP that probably remodels membranes and may function in mitochondrial and peroxisomal division.
Catalytic activity	GTP + H2O = GDP + phosphate.
Subcellular location	Cytoplasm › cytosol. Membrane By similarity. Note: Mainly cytosolic. Also membrane-associated. May associate to mitochondria and peroxisomal membranes By similarity.
Sequence similarities	Belongs to the dynamin family. Contains 1 GED domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 691	691	Dynamin-1-like protein		PRO_0000206569
Regions
	Domain	599 – 690	92	GED
	Nucleotide binding	32 – 39	8	GTP By similarity
	Nucleotide binding	145 – 149	5	GTP By similarity
	Nucleotide binding	214 – 217	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SXN5-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: FF3B9A167B2420C7	FASTA	691	77,263
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIAV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR 70 80 90 100 110 120 RPLILQLVHV DPEDRRKTSE ENGVDGEEWG KFLHTKNKIY TDFDEIRQEI ENETERVSGN 130 140 150 160 170 180 NKGISDEPIH LKIFSPHVVN LTLVDLPGIT KVPVGDQPKD IELQIRELIL KYISNPNSII 190 200 210 220 230 240 LAVTAANTDM ATSEALKVAR EVDPDGRRTL AVVTKLDLMD AGTDAMDVLM GRVIPVKLGL 250 260 270 280 290 300 IGVVNRSQLD INNKKSVADS IRDEHGFLQK KYPSLANRNG TKYLARTLNR LLMHHIRDCL 310 320 330 340 350 360 PELKTRINVL SAQYQSLLSS YGEPVEDMSA TLLQLITKFA TEYCNTIEGT AKYIETAELC 370 380 390 400 410 420 GGARICYIFH ETFGRTLESV DPLGGLTTID VLTAIRNATG PRPALFVPEV SFELLVKRQV 430 440 450 460 470 480 KRLEEPSLRC VELVHEEMQR IIQHCSNYST QELLRFPKLH DAIVEVVTSL LRKRLPVTNE 490 500 510 520 530 540 MVHNLVAIEL AYINTKHPDF ADACGLMNNN IEEQRRNRMR ELPTSVPRDK MAGGAQAEQE 550 560 570 580 590 600 GGTGTWRGML KKGDEGQGEE KTKLQSSIPA SPQKGHAVNL LDVPVPVARK LSAREQRDCE 610 620 630 640 650 660 VIERLIKSYF LIVRKNIQDS VPKAVMHFLV NHVKDSLQSE LVGQLYKPAL LDDLLTESED 670 680 690 MAQRRNEAAD MLKALQKASQ VIAEIRETHL W

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC055521 mRNA. Translation: AAH55521.1.
IPI	IPI00492723.
RefSeq	NP_957216.1.
UniGene	Dr.77967
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q7SXN5.
Genome annotation databases
Ensembl	ENSDART00000006840; ENSDARP00000006315; ENSDARG00000015006; Danio rerio. [Genome view]
GeneID	393896.
KEGG	dre:393896.
NMPDR	fig|7955.3.peg.16727.
Organism-specific databases
CTD	393896.
ZFIN	ZDB-GENE-040426-1556. dnm1l.
Phylogenomic databases
HOGENOM	Q7SXN5.
HOVERGEN	Q7SXN5.
OMA	NDPATWK.
Enzyme and pathway databases
BRENDA	3.6.5.5. 96826.
Gene expression databases
ArrayExpress	Q7SXN5.
Bgee	Q7SXN5.
Family and domain databases
InterPro	IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR003130. GED. [Graphical view]
Pfam	PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. [Graphical view]
PRINTS	PR00195. DYNAMIN.
SMART	SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. [Graphical view]
PROSITE	PS00410. DYNAMIN. 1 hit. PS51388. GED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNM1L_DANRE

Accession

Primary (citable) accession number: Q7SXN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project