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Q7SXM0

- HDAC8_DANRE

UniProt

Q7SXM0 - HDAC8_DANRE

Protein

Histone deacetylase 8

Gene

hdac8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Cofactori

    Binds 1 divalent metal cation per subunit.

    Enzyme regulationi

    Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021SubstrateBy similarity
    Active sitei144 – 1441Proton acceptorBy similarity
    Binding sitei152 – 1521Substrate; via carbonyl oxygenBy similarity
    Metal bindingi179 – 1791Divalent metal cationBy similarity
    Metal bindingi181 – 1811Divalent metal cationBy similarity
    Metal bindingi268 – 2681Divalent metal cationBy similarity
    Binding sitei307 – 3071SubstrateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 8 (EC:3.5.1.98)
    Short name:
    HD8
    Gene namesi
    Name:hdac8
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-2772. hdac8.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Histone deacetylase 8PRO_0000389509Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000100012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7SXM0.
    SMRiQ7SXM0. Positions 18-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 325311Histone deacetylaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000225180.
    HOVERGENiHBG057112.
    InParanoidiQ7SXM0.
    KOiK11405.
    PhylomeDBiQ7SXM0.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    Q7SXM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKSDSNDD KSRTRSVVYV YSPEYIQTCD SLSKVPNRAS MVHSLIEAYG    50
    LLKYMRVVKP HVASIEEMAV FHTDSYLQHL HKISQDGDND DPQSADFGLG 100
    YDCPVVEGIF DYAAAVGGAT LTAAQNLLDG KCDVAINWAG GWHHAKKDEA 150
    SGSCYVNDAV LGILKLREKY DRVLYVDVDL HHGDGVEDAF SFTSKVMTVS 200
    LHKFSPGFFP GTGDVTDTGL GKGRWYAVNV PFEDGVRDDR YCQTFTSVMQ 250
    EVKALFNPEA VVMQLGADTM AGDPMCSFNM TPVGVAKCLT YILGWELPTL 300
    LLGGGGYNLA NTARCWTYLT GTVLGQTLSS EIPDHEFFTE YGPDYSLEIS 350
    PSCRPDRNES QHLERVISTI KGNLKNVV 378
    Length:378
    Mass (Da):41,583
    Last modified:October 1, 2003 - v1
    Checksum:iED4D6FD03D62C4DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC055541 mRNA. Translation: AAH55541.1.
    RefSeqiNP_998596.1. NM_213431.1.
    UniGeneiDr.3849.

    Genome annotation databases

    GeneIDi406740.
    KEGGidre:406740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC055541 mRNA. Translation: AAH55541.1 .
    RefSeqi NP_998596.1. NM_213431.1.
    UniGenei Dr.3849.

    3D structure databases

    ProteinModelPortali Q7SXM0.
    SMRi Q7SXM0. Positions 18-378.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000100012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 406740.
    KEGGi dre:406740.

    Organism-specific databases

    CTDi 55869.
    ZFINi ZDB-GENE-040426-2772. hdac8.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000225180.
    HOVERGENi HBG057112.
    InParanoidi Q7SXM0.
    KOi K11405.
    PhylomeDBi Q7SXM0.

    Miscellaneous databases

    NextBioi 20818259.
    PROi Q7SXM0.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiHDAC8_DANRE
    AccessioniPrimary (citable) accession number: Q7SXM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3