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Q7SXM0

- HDAC8_DANRE

UniProt

Q7SXM0 - HDAC8_DANRE

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Protein

Histone deacetylase 8

Gene
hdac8
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactori

Binds 1 divalent metal cation per subunit.

Enzyme regulationi

Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021Substrate By similarity
Active sitei144 – 1441Proton acceptor By similarity
Binding sitei152 – 1521Substrate; via carbonyl oxygen By similarity
Metal bindingi179 – 1791Divalent metal cation By similarity
Metal bindingi181 – 1811Divalent metal cation By similarity
Metal bindingi268 – 2681Divalent metal cation By similarity
Binding sitei307 – 3071Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 8 (EC:3.5.1.98)
Short name:
HD8
Gene namesi
Name:hdac8
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-2772. hdac8.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Histone deacetylase 8PRO_0000389509Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000100012.

Structurei

3D structure databases

ProteinModelPortaliQ7SXM0.
SMRiQ7SXM0. Positions 18-378.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 325311Histone deacetylase By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
HOVERGENiHBG057112.
InParanoidiQ7SXM0.
KOiK11405.
PhylomeDBiQ7SXM0.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q7SXM0-1 [UniParc]FASTAAdd to Basket

« Hide

MSEKSDSNDD KSRTRSVVYV YSPEYIQTCD SLSKVPNRAS MVHSLIEAYG    50
LLKYMRVVKP HVASIEEMAV FHTDSYLQHL HKISQDGDND DPQSADFGLG 100
YDCPVVEGIF DYAAAVGGAT LTAAQNLLDG KCDVAINWAG GWHHAKKDEA 150
SGSCYVNDAV LGILKLREKY DRVLYVDVDL HHGDGVEDAF SFTSKVMTVS 200
LHKFSPGFFP GTGDVTDTGL GKGRWYAVNV PFEDGVRDDR YCQTFTSVMQ 250
EVKALFNPEA VVMQLGADTM AGDPMCSFNM TPVGVAKCLT YILGWELPTL 300
LLGGGGYNLA NTARCWTYLT GTVLGQTLSS EIPDHEFFTE YGPDYSLEIS 350
PSCRPDRNES QHLERVISTI KGNLKNVV 378
Length:378
Mass (Da):41,583
Last modified:October 1, 2003 - v1
Checksum:iED4D6FD03D62C4DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC055541 mRNA. Translation: AAH55541.1.
RefSeqiNP_998596.1. NM_213431.1.
UniGeneiDr.3849.

Genome annotation databases

GeneIDi406740.
KEGGidre:406740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC055541 mRNA. Translation: AAH55541.1 .
RefSeqi NP_998596.1. NM_213431.1.
UniGenei Dr.3849.

3D structure databases

ProteinModelPortali Q7SXM0.
SMRi Q7SXM0. Positions 18-378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000100012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 406740.
KEGGi dre:406740.

Organism-specific databases

CTDi 55869.
ZFINi ZDB-GENE-040426-2772. hdac8.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000225180.
HOVERGENi HBG057112.
InParanoidi Q7SXM0.
KOi K11405.
PhylomeDBi Q7SXM0.

Miscellaneous databases

NextBioi 20818259.
PROi Q7SXM0.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHDAC8_DANRE
AccessioniPrimary (citable) accession number: Q7SXM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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