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Q7SXM0 (HDAC8_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone deacetylase 8
Short name=HD8
EC=3.5.1.98
Gene names
Name:hdac8
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactor

Binds 1 divalent metal cation per subunit.

Enzyme regulation

Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Histone deacetylase 8
PRO_0000389509

Regions

Region15 – 325311Histone deacetylase By similarity

Sites

Active site1441Proton acceptor By similarity
Metal binding1791Divalent metal cation By similarity
Metal binding1811Divalent metal cation By similarity
Metal binding2681Divalent metal cation By similarity
Binding site1021Substrate By similarity
Binding site1521Substrate; via carbonyl oxygen By similarity
Binding site3071Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7SXM0 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: ED4D6FD03D62C4DF

FASTA37841,583
        10         20         30         40         50         60 
MSEKSDSNDD KSRTRSVVYV YSPEYIQTCD SLSKVPNRAS MVHSLIEAYG LLKYMRVVKP 

        70         80         90        100        110        120 
HVASIEEMAV FHTDSYLQHL HKISQDGDND DPQSADFGLG YDCPVVEGIF DYAAAVGGAT 

       130        140        150        160        170        180 
LTAAQNLLDG KCDVAINWAG GWHHAKKDEA SGSCYVNDAV LGILKLREKY DRVLYVDVDL 

       190        200        210        220        230        240 
HHGDGVEDAF SFTSKVMTVS LHKFSPGFFP GTGDVTDTGL GKGRWYAVNV PFEDGVRDDR 

       250        260        270        280        290        300 
YCQTFTSVMQ EVKALFNPEA VVMQLGADTM AGDPMCSFNM TPVGVAKCLT YILGWELPTL 

       310        320        330        340        350        360 
LLGGGGYNLA NTARCWTYLT GTVLGQTLSS EIPDHEFFTE YGPDYSLEIS PSCRPDRNES 

       370 
QHLERVISTI KGNLKNVV

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC055541 mRNA. Translation: AAH55541.1.
IPIIPI00494370.
RefSeqNP_998596.1. NM_213431.1.
UniGeneDr.3849.

3D structure databases

HSSPHSSP built from PDB template 1VKG based on UniProtKB Q9BY41.
ProteinModelPortalQ7SXM0.
SMRQ7SXM0. Positions 18-378.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID406740.
KEGGdre:406740.

Organism-specific databases

CTD55869.
ZFINZDB-GENE-040426-2772. hdac8.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000225180.
HOVERGENHBG057112.
InParanoidQ7SXM0.
KOK11405.
OrthoDBEOG405S1D.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Other

NextBio20818259.

Entry information

Entry nameHDAC8_DANRE
AccessionPrimary (citable) accession number: Q7SXM0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: October 1, 2003
Last modified: April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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