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Protein

TATA-box-binding protein

Gene

tbp

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subset of genes at the mid-blastula transition (MBT). Negatively regulates the expression of other embryonic genes, including autoregulation of the tbp promoter itself. Also functions within a transcription-dependent mechanism to direct the temporally-regulated degradation of a subset of maternal mRNAs after the MBT. This is part of a general mechanism to regulate the maternal to zygotic transition and is required for normal embryonic development. Binds to promoters of a subset of genes. Required for gastrulation.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, initiation Source: ZFIN
  • gastrulation Source: UniProtKB
  • mRNA catabolic process Source: UniProtKB
  • transcription by RNA polymerase II Source: UniProtKB
  • transcription by RNA polymerase III Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processGastrulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DRE-5250924 B-WICH complex positively regulates rRNA expression
R-DRE-674695 RNA Polymerase II Pre-transcription Events
R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
R-DRE-6807505 RNA polymerase II transcribes snRNA genes
R-DRE-73762 RNA Polymerase I Transcription Initiation
R-DRE-73772 RNA Polymerase I Promoter Escape
R-DRE-73776 RNA Polymerase II Promoter Escape
R-DRE-73777 RNA Polymerase I Chain Elongation
R-DRE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DRE-73863 RNA Polymerase I Transcription Termination
R-DRE-75953 RNA Polymerase II Transcription Initiation
R-DRE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DRE-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-DRE-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-DRE-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-DRE-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding proteinImported
Short name:
zTBP1 Publication
Alternative name(s):
TATA sequence-binding proteinBy similarity
TATA-binding factorBy similarity
TATA-box factorBy similarity
Short name:
zfTBF1 Publication
Transcription initiation factor TFIID TBP subunitBy similarity
Gene namesi
Name:tbpImported
ORF Names:si:ch211-202m22.5
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030616-563 tbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003486081 – 302TATA-box-binding proteinAdd BLAST302

Proteomic databases

PaxDbiQ7SXL3
PRIDEiQ7SXL3

Expressioni

Tissue specificityi

Enriched in testis but hardly detectable in the ovary (at protein level).1 Publication

Developmental stagei

Expressed both maternally and zygotically. Expression is very low in the zygote, increasing from morula stage onward to reach a peak during early gastrulation. Levels then rapidly decline during neurula and organogenesis stages (at protein level). There is an inverse correlation between mRNA and protein levels at the late blastula and early gastrula stages.1 Publication

Gene expression databases

BgeeiENSDARG00000014994

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010211

Structurei

3D structure databases

ProteinModelPortaliQ7SXL3
SMRiQ7SXL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati128 – 2041Sequence analysisAdd BLAST77
Repeati218 – 2952Sequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 87Gln-richSequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the TBP family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
HOGENOMiHOG000105164
HOVERGENiHBG044997
InParanoidiQ7SXL3
KOiK03120
OMAiMMPYGSG
OrthoDBiEOG091G0ENY
PhylomeDBiQ7SXL3
TreeFamiTF300102

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

Q7SXL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQNNSLPPF AQGLASPQGA MTPGLPIFSP MMPYGTGLTP QPVQNSNSLS
60 70 80 90 100
LLEEQQRQQQ QQQAASQQQG GMVGGSGQTP QLYHSTQAVS TTTALPGNTP
110 120 130 140 150
LYTTPLTPMT PITPATPASE SSGIVPQLQN IVSTVNLGCK LDLKTIALRA
160 170 180 190 200
RNAEYNPKRF AAVIMRIREP RTTALIFSSG KMVCTGAKSE EQSRLAARKY
210 220 230 240 250
ARVVQKLGFP AKFLDFKIQN MVGSCDVKFP IRLEGLVLTH QQFSSYEPEL
260 270 280 290 300
FPGLIYRMIK PRIVLLIFVS GKVVLTGAKV RGEIYEAFEN IYPILKGFRK

TS
Length:302
Mass (Da):33,019
Last modified:October 1, 2003 - v1
Checksum:iC63A6C1D2F7E1D50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184C → G in AAQ07596 (PubMed:15062100).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168633 mRNA Translation: AAO34524.1
AF503449 mRNA Translation: AAQ07596.1
AL772388 Genomic DNA Translation: CAK04406.1
BC055549 mRNA Translation: AAH55549.1
BC065860 mRNA Translation: AAH65860.1
RefSeqiNP_956390.1, NM_200096.1
UniGeneiDr.117556

Genome annotation databases

EnsembliENSDART00000016211; ENSDARP00000010211; ENSDARG00000014994
GeneIDi368882
KEGGidre:368882

Similar proteinsi

Entry informationi

Entry nameiTBP_DANRE
AccessioniPrimary (citable) accession number: Q7SXL3
Secondary accession number(s): Q71H62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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