Reviewed, UniProtKB/Swiss-Prot Q7SXK5 (HUTI_DANRE)

Names and origin

Protein names

Recommended name:
    Probable imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Amidohydrolase domain-containing protein 1

Gene names

Name:

amdhd1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.
Cofactor	Binds 1 zinc or iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Probable imidazolonepropionase		PRO_0000282584
Sites
	Metal binding	88	1	Zinc or iron By similarity
	Metal binding	90	1	Zinc or iron By similarity
	Metal binding	261	1	Zinc or iron By similarity
	Metal binding	335	1	Zinc or iron By similarity
	Binding site	97	1	Substrate By similarity
	Binding site	110	1	Substrate By similarity
	Binding site	160	1	Substrate By similarity
	Binding site	193	1	Substrate By similarity
	Binding site	264	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SXK5-1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 6E818B948306DE19	FASTA	433	46,904
	10 20 30 40 50 60 MSANSFKLLV KNATQLVLVC RNGEKYLTRD EMQALAVLEN ASVLIGHDGL IKAVGPADVI 70 80 90 100 110 120 ETQFEGAKFD NVLDASGMCV LPGLVDAHTH PVWAGDRVHE FAMKLAGATY MEVHEAGGGI 130 140 150 160 170 180 HFTVAHTRSA SEQHLLAALK SRLERMMRAG TTLVECKSGY GLELDIEVKM LRVINSARKS 190 200 210 220 230 240 LPIGISATYC GAHAVPKGKT MEEATKDIVA VQLPKIKHLS ASGDLQVDNI DVFCEKGVFD 250 260 270 280 290 300 LTSTRCILQA GKDMGLNINF HGDELHPMNS AHLGAELGAL AISHLEEVTD DGIVAMAKSK 310 320 330 340 350 360 TSAVLLPTTA YILRLTPPRA RDMLDAGVIV ALGSDFNPNA YCFSMPMVMH LACVMMKMSM 370 380 390 400 410 420 PEALAASTIN AAYALNRSQT HGSLEVGKQG DLVIINAPRW EHLVYQFGGH QELIRYVIIK 430 GDFVYENDKV LNL

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC055559 mRNA. Translation: AAH55559.1. Different initiation.
IPI	IPI00509716.
UniGene	Dr.104637
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000007366. Danio rerio. [Contig view]
Phylogenomic databases
HOVERGEN	Q7SXK5.
Enzyme and pathway databases
BRENDA	3.5.2.7. 96826.
Gene expression databases
Bgee	Q7SXK5.
Family and domain databases
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_DANRE

Accession

Primary (citable) accession number: Q7SXK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	February 10, 2009
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project