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Protein

7-dehydrocholesterol reductase

Gene

dhcr7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).By similarity

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathway: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:dhcr7
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030912-9. dhcr7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4784787-dehydrocholesterol reductasePRO_0000207505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124869.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72042.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ7SXF1.
KOiK00213.
PhylomeDBiQ7SXF1.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SXF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMASDRVRKR HKGSANGAQT VEKEPSKEPA QWGRAWEVDW FSLSGVILLL
60 70 80 90 100
CFAPFLVSFF IMACDQYQCS ISHPLLDLYN GDATLFTIWN RAPSFTWAAA
110 120 130 140 150
KIYAIWVTFQ VVLYMCVPDF LHKILPGYVG GVQDGARTPA GLINKYEVNG
160 170 180 190 200
LQCWLITHVL WVLNAQHFHW FSPTIIIDNW IPLLWCTNIL GYAVSTFAFI
210 220 230 240 250
KAYLFPTNPE DCKFTGNMFY NYMMGIEFNP RIGKWFDFKL FFNGRPGIVA
260 270 280 290 300
WTLINLSYAA KQQELYGYVT NSMILVNVLQ AVYVVDFFWN EAWYLKTIDI
310 320 330 340 350
CHDHFGWYLG WGDCVWLPFL YTLQGLYLVY NPIQLSTPHA AGVLILGLVG
360 370 380 390 400
YYIFRVTNHQ KDLFRRTEGN CSIWGKKPTF IECSYQSADG AIHKSKLMTS
410 420 430 440 450
GFWGVARHMN YTGDLMGSLA YCLACGGNHL LPYFYIIYMT ILLVHRCIRD
460 470
EHRCSNKYGK DWERYTAAVS YRLLPNIF
Length:478
Mass (Da):55,189
Last modified:October 1, 2003 - v1
Checksum:iEFFDB76773E4ECD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055631 mRNA. Translation: AAH55631.1.
RefSeqiNP_958487.1. NM_201330.1.
UniGeneiDr.83736.

Genome annotation databases

GeneIDi378446.
KEGGidre:378446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055631 mRNA. Translation: AAH55631.1.
RefSeqiNP_958487.1. NM_201330.1.
UniGeneiDr.83736.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378446.
KEGGidre:378446.

Organism-specific databases

CTDi1717.
ZFINiZDB-GENE-030912-9. dhcr7.

Phylogenomic databases

eggNOGiNOG72042.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ7SXF1.
KOiK00213.
PhylomeDBiQ7SXF1.

Enzyme and pathway databases

UniPathwayiUPA00063.

Miscellaneous databases

NextBioi20813772.
PROiQ7SXF1.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDHCR7_DANRE
AccessioniPrimary (citable) accession number: Q7SXF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.