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Q7SXF1

- DHCR7_DANRE

UniProt

Q7SXF1 - DHCR7_DANRE

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Protein
7-dehydrocholesterol reductase
Gene
dhcr7
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi

GO - Molecular functioni

  1. 7-dehydrocholesterol reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. cholesterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:dhcr7
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030912-9. dhcr7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Transmembranei180 – 20021Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei309 – 32921Helical; Reviewed prediction
Add
BLAST
Transmembranei333 – 35321Helical; Reviewed prediction
Add
BLAST
Transmembranei424 – 44421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4784787-dehydrocholesterol reductase
PRO_0000207505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000027840.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72042.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ7SXF1.
KOiK00213.
PhylomeDBiQ7SXF1.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SXF1-1 [UniParc]FASTAAdd to Basket

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MMASDRVRKR HKGSANGAQT VEKEPSKEPA QWGRAWEVDW FSLSGVILLL    50
CFAPFLVSFF IMACDQYQCS ISHPLLDLYN GDATLFTIWN RAPSFTWAAA 100
KIYAIWVTFQ VVLYMCVPDF LHKILPGYVG GVQDGARTPA GLINKYEVNG 150
LQCWLITHVL WVLNAQHFHW FSPTIIIDNW IPLLWCTNIL GYAVSTFAFI 200
KAYLFPTNPE DCKFTGNMFY NYMMGIEFNP RIGKWFDFKL FFNGRPGIVA 250
WTLINLSYAA KQQELYGYVT NSMILVNVLQ AVYVVDFFWN EAWYLKTIDI 300
CHDHFGWYLG WGDCVWLPFL YTLQGLYLVY NPIQLSTPHA AGVLILGLVG 350
YYIFRVTNHQ KDLFRRTEGN CSIWGKKPTF IECSYQSADG AIHKSKLMTS 400
GFWGVARHMN YTGDLMGSLA YCLACGGNHL LPYFYIIYMT ILLVHRCIRD 450
EHRCSNKYGK DWERYTAAVS YRLLPNIF 478
Length:478
Mass (Da):55,189
Last modified:October 1, 2003 - v1
Checksum:iEFFDB76773E4ECD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC055631 mRNA. Translation: AAH55631.1.
RefSeqiNP_958487.1. NM_201330.1.
UniGeneiDr.83736.

Genome annotation databases

GeneIDi378446.
KEGGidre:378446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC055631 mRNA. Translation: AAH55631.1 .
RefSeqi NP_958487.1. NM_201330.1.
UniGenei Dr.83736.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000027840.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378446.
KEGGi dre:378446.

Organism-specific databases

CTDi 1717.
ZFINi ZDB-GENE-030912-9. dhcr7.

Phylogenomic databases

eggNOGi NOG72042.
HOGENOMi HOG000193296.
HOVERGENi HBG007825.
InParanoidi Q7SXF1.
KOi K00213.
PhylomeDBi Q7SXF1.

Enzyme and pathway databases

UniPathwayi UPA00063 .

Miscellaneous databases

NextBioi 20813772.
PROi Q7SXF1.

Family and domain databases

InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view ]
Pfami PF01222. ERG4_ERG24. 1 hit.
[Graphical view ]
PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDHCR7_DANRE
AccessioniPrimary (citable) accession number: Q7SXF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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