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Protein

7-dehydrocholesterol reductase

Gene

dhcr7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).By similarity

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei361NADPBy similarity1
Binding sitei365NADPBy similarity1
Binding sitei398NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei403NADPBy similarity1
Binding sitei450NADPBy similarity1
Binding sitei465NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi410 – 411NADPBy similarity2
Nucleotide bindingi454 – 458NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:dhcr7
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030912-9. dhcr7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075051 – 4787-dehydrocholesterol reductaseAdd BLAST478

Proteomic databases

PaxDbiQ7SXF1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124869.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1435. Eukaryota.
ENOG410XP67. LUCA.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ7SXF1.
KOiK00213.
PhylomeDBiQ7SXF1.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SXF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMASDRVRKR HKGSANGAQT VEKEPSKEPA QWGRAWEVDW FSLSGVILLL
60 70 80 90 100
CFAPFLVSFF IMACDQYQCS ISHPLLDLYN GDATLFTIWN RAPSFTWAAA
110 120 130 140 150
KIYAIWVTFQ VVLYMCVPDF LHKILPGYVG GVQDGARTPA GLINKYEVNG
160 170 180 190 200
LQCWLITHVL WVLNAQHFHW FSPTIIIDNW IPLLWCTNIL GYAVSTFAFI
210 220 230 240 250
KAYLFPTNPE DCKFTGNMFY NYMMGIEFNP RIGKWFDFKL FFNGRPGIVA
260 270 280 290 300
WTLINLSYAA KQQELYGYVT NSMILVNVLQ AVYVVDFFWN EAWYLKTIDI
310 320 330 340 350
CHDHFGWYLG WGDCVWLPFL YTLQGLYLVY NPIQLSTPHA AGVLILGLVG
360 370 380 390 400
YYIFRVTNHQ KDLFRRTEGN CSIWGKKPTF IECSYQSADG AIHKSKLMTS
410 420 430 440 450
GFWGVARHMN YTGDLMGSLA YCLACGGNHL LPYFYIIYMT ILLVHRCIRD
460 470
EHRCSNKYGK DWERYTAAVS YRLLPNIF
Length:478
Mass (Da):55,189
Last modified:October 1, 2003 - v1
Checksum:iEFFDB76773E4ECD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055631 mRNA. Translation: AAH55631.1.
RefSeqiNP_958487.1. NM_201330.1.
UniGeneiDr.83736.

Genome annotation databases

GeneIDi378446.
KEGGidre:378446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055631 mRNA. Translation: AAH55631.1.
RefSeqiNP_958487.1. NM_201330.1.
UniGeneiDr.83736.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124869.

Proteomic databases

PaxDbiQ7SXF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378446.
KEGGidre:378446.

Organism-specific databases

CTDi1717.
ZFINiZDB-GENE-030912-9. dhcr7.

Phylogenomic databases

eggNOGiKOG1435. Eukaryota.
ENOG410XP67. LUCA.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ7SXF1.
KOiK00213.
PhylomeDBiQ7SXF1.

Enzyme and pathway databases

UniPathwayiUPA00063.

Miscellaneous databases

PROiQ7SXF1.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHCR7_DANRE
AccessioniPrimary (citable) accession number: Q7SXF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: October 5, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.