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Q7SXF1 (DHCR7_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
7-dehydrocholesterol reductase

Short name=7-DHC reductase
EC=1.3.1.21
Alternative name(s):
Sterol Delta(7)-reductase
Gene names
Name:dhcr7
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.

Catalytic activity

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ERG4/ERG24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4784787-dehydrocholesterol reductase
PRO_0000207505

Regions

Transmembrane43 – 6321Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane269 – 28921Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane333 – 35321Helical; Potential
Transmembrane424 – 44421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7SXF1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EFFDB76773E4ECD7

FASTA47855,189
        10         20         30         40         50         60 
MMASDRVRKR HKGSANGAQT VEKEPSKEPA QWGRAWEVDW FSLSGVILLL CFAPFLVSFF 

        70         80         90        100        110        120 
IMACDQYQCS ISHPLLDLYN GDATLFTIWN RAPSFTWAAA KIYAIWVTFQ VVLYMCVPDF 

       130        140        150        160        170        180 
LHKILPGYVG GVQDGARTPA GLINKYEVNG LQCWLITHVL WVLNAQHFHW FSPTIIIDNW 

       190        200        210        220        230        240 
IPLLWCTNIL GYAVSTFAFI KAYLFPTNPE DCKFTGNMFY NYMMGIEFNP RIGKWFDFKL 

       250        260        270        280        290        300 
FFNGRPGIVA WTLINLSYAA KQQELYGYVT NSMILVNVLQ AVYVVDFFWN EAWYLKTIDI 

       310        320        330        340        350        360 
CHDHFGWYLG WGDCVWLPFL YTLQGLYLVY NPIQLSTPHA AGVLILGLVG YYIFRVTNHQ 

       370        380        390        400        410        420 
KDLFRRTEGN CSIWGKKPTF IECSYQSADG AIHKSKLMTS GFWGVARHMN YTGDLMGSLA 

       430        440        450        460        470 
YCLACGGNHL LPYFYIIYMT ILLVHRCIRD EHRCSNKYGK DWERYTAAVS YRLLPNIF 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC055631 mRNA. Translation: AAH55631.1.
RefSeqNP_958487.1. NM_201330.1.
UniGeneDr.83736.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000027840.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID378446.
KEGGdre:378446.

Organism-specific databases

CTD1717.
ZFINZDB-GENE-030912-9. dhcr7.

Phylogenomic databases

eggNOGNOG72042.
HOGENOMHOG000193296.
HOVERGENHBG007825.
InParanoidQ7SXF1.
KOK00213.
PhylomeDBQ7SXF1.

Enzyme and pathway databases

UniPathwayUPA00063.

Family and domain databases

InterProIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813772.
PROQ7SXF1.

Entry information

Entry nameDHCR7_DANRE
AccessionPrimary (citable) accession number: Q7SXF1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways