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Q7SXF1

- DHCR7_DANRE

UniProt

Q7SXF1 - DHCR7_DANRE

Protein

7-dehydrocholesterol reductase

Gene

dhcr7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).By similarity

    Catalytic activityi

    Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. 7-dehydrocholesterol reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cholesterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00063.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    7-dehydrocholesterol reductase (EC:1.3.1.21)
    Short name:
    7-DHC reductase
    Alternative name(s):
    Sterol Delta(7)-reductase
    Gene namesi
    Name:dhcr7
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-030912-9. dhcr7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4784787-dehydrocholesterol reductasePRO_0000207505Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000027840.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERG4/ERG24 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72042.
    HOGENOMiHOG000193296.
    HOVERGENiHBG007825.
    InParanoidiQ7SXF1.
    KOiK00213.
    PhylomeDBiQ7SXF1.

    Family and domain databases

    InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view]
    PfamiPF01222. ERG4_ERG24. 1 hit.
    [Graphical view]
    PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SXF1-1 [UniParc]FASTAAdd to Basket

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    MMASDRVRKR HKGSANGAQT VEKEPSKEPA QWGRAWEVDW FSLSGVILLL    50
    CFAPFLVSFF IMACDQYQCS ISHPLLDLYN GDATLFTIWN RAPSFTWAAA 100
    KIYAIWVTFQ VVLYMCVPDF LHKILPGYVG GVQDGARTPA GLINKYEVNG 150
    LQCWLITHVL WVLNAQHFHW FSPTIIIDNW IPLLWCTNIL GYAVSTFAFI 200
    KAYLFPTNPE DCKFTGNMFY NYMMGIEFNP RIGKWFDFKL FFNGRPGIVA 250
    WTLINLSYAA KQQELYGYVT NSMILVNVLQ AVYVVDFFWN EAWYLKTIDI 300
    CHDHFGWYLG WGDCVWLPFL YTLQGLYLVY NPIQLSTPHA AGVLILGLVG 350
    YYIFRVTNHQ KDLFRRTEGN CSIWGKKPTF IECSYQSADG AIHKSKLMTS 400
    GFWGVARHMN YTGDLMGSLA YCLACGGNHL LPYFYIIYMT ILLVHRCIRD 450
    EHRCSNKYGK DWERYTAAVS YRLLPNIF 478
    Length:478
    Mass (Da):55,189
    Last modified:October 1, 2003 - v1
    Checksum:iEFFDB76773E4ECD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC055631 mRNA. Translation: AAH55631.1.
    RefSeqiNP_958487.1. NM_201330.1.
    UniGeneiDr.83736.

    Genome annotation databases

    GeneIDi378446.
    KEGGidre:378446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC055631 mRNA. Translation: AAH55631.1 .
    RefSeqi NP_958487.1. NM_201330.1.
    UniGenei Dr.83736.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000027840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 378446.
    KEGGi dre:378446.

    Organism-specific databases

    CTDi 1717.
    ZFINi ZDB-GENE-030912-9. dhcr7.

    Phylogenomic databases

    eggNOGi NOG72042.
    HOGENOMi HOG000193296.
    HOVERGENi HBG007825.
    InParanoidi Q7SXF1.
    KOi K00213.
    PhylomeDBi Q7SXF1.

    Enzyme and pathway databases

    UniPathwayi UPA00063 .

    Miscellaneous databases

    NextBioi 20813772.
    PROi Q7SXF1.

    Family and domain databases

    InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view ]
    Pfami PF01222. ERG4_ERG24. 1 hit.
    [Graphical view ]
    PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiDHCR7_DANRE
    AccessioniPrimary (citable) accession number: Q7SXF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3