Q7SX78 (Q7SX78_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Sizzled EMBL AAO34663.1

Submitted name:
Szl protein EMBL AAI16573.1

Gene names

Name:

szl ZFIN ZDB-GENE-030530-1 EMBL BAC77267.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAO34663.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FZ (frizzled) domain. SAAS SAAS015526

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS015526
Molecular function	Developmental protein SAAS SAAS015526
PTM	Disulfide bond SAAS SAAS020067
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW determination of dorsal identity Inferred from mutant phenotype. Source: ZFIN negative regulation of BMP signaling pathway Inferred from mutant phenotype. Source: ZFIN protein stabilization Inferred from direct assay. Source: ZFIN
Molecular function	protein binding Inferred from physical interaction. Source: ZFIN
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7SX78 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 2DBF5CEA2DF2B79D	FASTA	282	31,455
	10 20 30 40 50 60 MSLFSLLLFF SLAAHTGAFD LGQTTRCVPI PPQMSVCQDV PYSEMRLPNL LGHGSLEEAA 70 80 90 100 110 120 PRSDDLRTLL HTGCHPQARA FVCSLIAPVC LDRFIQPCRS VCLAVKESCS PVLACHGHSW 130 140 150 160 170 180 PESLNCERFP EQDDCLTPLP KHISAFSKEF PQPACQSCPS VQESPSLKTL LDSLCLNDFA 190 200 210 220 230 240 VKVKIMRRRV PSSEPEFTVE GAVELIERGP LMPYDTASLL QRWMLINLRC AHALVRPGRA 250 260 270 280 QLYLITGKMR AGGSIEIANL FPWLKKDLHI ATATRKWKHY KC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling." Yabe T., Shimizu T., Muraoka O., Bae Y., Hirata T., Nojima H., Kawakami A., Hirano T., Hibi M. Development 130:2705-2716(2003) [PubMed: 12736214] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein." Martyn U., Schulte-Merker S. Dev. Biol. 260:58-67(2003) [PubMed: 12885555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo EMBL AAI16573.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116572 mRNA. Translation: AAI16573.1. AY189978 mRNA. Translation: AAO34663.1. AB093587 mRNA. Translation: BAC77267.1.
IPI	IPI00502499.
RefSeq	NP_858049.1. NM_181663.1.
UniGene	Dr.84079.
3D structure databases
HSSP	HSSP built from PDB template 1IJX based on UniProtKB P97401.
ProteinModelPortal	Q7SX78.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7SX78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	353294.
KEGG	dre:353294.
Organism-specific databases
CTD	353294.
ZFIN	ZDB-GENE-030530-1. szl.
Phylogenomic databases
GeneTree	ENSGT00560000076776.
HOVERGEN	HBG052928.
InParanoid	Q7SX78.
PhylomeDB	Q7SX78.
Gene expression databases
ArrayExpress	Q7SX78.
Bgee	Q7SX78.
Family and domain databases
InterPro	IPR015526. Frizzled-related. IPR020067. Frizzled_dom. IPR001134. Netrin_domain. [Graphical view]
Gene3D	G3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHER	PTHR11309. Fz_related. 1 hit.
Pfam	PF01392. Fz. 1 hit. [Graphical view]
SMART	SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50189. NTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7SX78_DANRE

Accession

Primary (citable) accession number: Q7SX78

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)