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Protein
Submitted name:

Pol polyprotein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol polyproteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B60X-ray2.20A/B1-62[»]
ProteinModelPortaliQ7SMT3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7SMT3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 8970Peptidase A2InterPro annotationAdd
BLAST
Domaini143 – 333191Reverse transcriptaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation
Contains 1 reverse transcriptase domain.UniRule annotation
Contains peptidase A2 domain.SAAS annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q7SMT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PQITLWQRPF VTIKIGGQLK EALLDTGADD TIFEDISLPG RWKPKLIGGI
60 70 80 90 100
GGFIKVRQYD QIPIEICGHK VIGTVLVGPT PANIIGRNLM TQIGCTLNFP
110 120 130 140 150
ISPIETVPVK LKPGMDGPRV KQWPLTEEKI KALVEICTEM EKEGKISKIG
160 170 180 190 200
PENPYNTPIF AIKKKNSDRW RKLVDFRELN KRTQDFWEVQ LGIPHPAGLK
210 220 230 240 250
KKKSVTVLDV GDAYFSVPLD KEFRKYTAFT IPSINNETPG IRYQYNVLPQ
260 270 280 290 300
GWKGSPAIFQ SSMTKILEPF RKQNPDIVIC QYMDDLYVGS DLEIGQHRIK
310 320 330 340 350
IEELREHLLR WGFTTPDKNH QKEPPFLWMG YELHPDKWTV QPIVLPEKDS

WTVNDIQK
Length:358
Mass (Da):40,978
Last modified:October 1, 2003 - v1
Checksum:i9D75BDBD340B0093
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei358 – 3581Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577907 Genomic RNA. Translation: CAE17412.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577907 Genomic RNA. Translation: CAE17412.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B60X-ray2.20A/B1-62[»]
ProteinModelPortaliQ7SMT3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ7SMT3.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7SMT3_9HIV1
AccessioniPrimary (citable) accession number: Q7SMT3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.