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Protein
Submitted name:

Pol polyprotein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol polyproteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B60X-ray2.20A/B1-99[»]
ProteinModelPortaliQ7SMT3.
SMRiQ7SMT3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7SMT3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 89Peptidase A2InterPro annotationAdd BLAST70
Domaini143 – 333Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
IPR000477. RT_dom.
PfamiView protein in Pfam
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q7SMT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PQITLWQRPF VTIKIGGQLK EALLDTGADD TIFEDISLPG RWKPKLIGGI
60 70 80 90 100
GGFIKVRQYD QIPIEICGHK VIGTVLVGPT PANIIGRNLM TQIGCTLNFP
110 120 130 140 150
ISPIETVPVK LKPGMDGPRV KQWPLTEEKI KALVEICTEM EKEGKISKIG
160 170 180 190 200
PENPYNTPIF AIKKKNSDRW RKLVDFRELN KRTQDFWEVQ LGIPHPAGLK
210 220 230 240 250
KKKSVTVLDV GDAYFSVPLD KEFRKYTAFT IPSINNETPG IRYQYNVLPQ
260 270 280 290 300
GWKGSPAIFQ SSMTKILEPF RKQNPDIVIC QYMDDLYVGS DLEIGQHRIK
310 320 330 340 350
IEELREHLLR WGFTTPDKNH QKEPPFLWMG YELHPDKWTV QPIVLPEKDS

WTVNDIQK
Length:358
Mass (Da):40,978
Last modified:October 1, 2003 - v1
Checksum:i9D75BDBD340B0093
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei358Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577907 Genomic RNA. Translation: CAE17412.1.

Similar proteinsi

Entry informationi

Entry nameiQ7SMT3_9HIV1
AccessioniPrimary (citable) accession number: Q7SMT3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Multifunctional enzymeSAAS annotation