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Q7SIG2

- CTR1_SOLIN

UniProt

Q7SIG2 - CTR1_SOLIN

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Protein

Chymotrypsin-1

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.1 PublicationPROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Charge relay system1 Publication
Active sitei87 – 871Charge relay system1 Publication
Active sitei178 – 1781Charge relay system1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.438.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-1 (EC:3.4.21.1)
Alternative name(s):
Chymotrypsin I
Soli C1
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Chymotrypsin-1PRO_0000248259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 421 PublicationPROSITE-ProRule annotation
Disulfide bondi151 ↔ 1641 PublicationPROSITE-ProRule annotation
Disulfide bondi174 ↔ 1981 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed in fourth instar larvae.1 Publication

Structurei

Secondary structure

1
222
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 206Combined sources
Beta strandi23 – 308Combined sources
Beta strandi32 – 387Combined sources
Helixi40 – 434Combined sources
Helixi49 – 513Combined sources
Beta strandi52 – 576Combined sources
Beta strandi66 – 7510Combined sources
Turni81 – 844Combined sources
Beta strandi89 – 957Combined sources
Beta strandi118 – 1247Combined sources
Beta strandi139 – 1468Combined sources
Helixi148 – 1547Combined sources
Beta strandi155 – 1573Combined sources
Beta strandi162 – 1654Combined sources
Beta strandi181 – 1844Combined sources
Beta strandi187 – 1948Combined sources
Turni197 – 1993Combined sources
Beta strandi200 – 2023Combined sources
Beta strandi204 – 2085Combined sources
Helixi209 – 2124Combined sources
Helixi213 – 2186Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EQ9X-ray1.70A/B1-222[»]
ProteinModelPortaliQ7SIG2.
SMRiQ7SIG2. Positions 1-222.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7SIG2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 221221Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SIG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IVGGKDAPVG KYPYQVSLRL SGSHRCGASI LDNNNVLTAA HCVDGLSNLN
60 70 80 90 100
RLKVHVGTNY LSESGDVYDV EDAVVNKNYD DFLLRNDVAL VHLTNPIKFN
110 120 130 140 150
DLVQPIKLST NDEDLESNPC TLTGWGSTRL GGNTPNALQE IELIVHPQKQ
160 170 180 190 200
CERDQWRVID SHICTLTKRG EGACHGDSGG PLVANGAQIG IVSFGSPCAL
210 220
GEPDVYTRVS SFVSWINANL KK
Length:222
Mass (Da):24,012
Last modified:December 15, 2003 - v1
Checksum:i862770BF2A44E652
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EQ9 X-ray 1.70 A/B 1-222 [» ]
ProteinModelPortali Q7SIG2.
SMRi Q7SIG2. Positions 1-222.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q7SIG2.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proteolytic enzymes from larvae of the fire ant, Solenopsis invicta. Isolation and characterization of four serine endopeptidases."
    Whitworth S.T., Blum M.S., Travis J.
    J. Biol. Chem. 273:14430-14434(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-22, CATALYTIC ACTIVITY, DEVELOPMENTAL STAGE.
    Tissue: Larva1 Publication.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH INHIBITOR, DISULFIDE BONDS.
    Tissue: Larva1 Publication.

Entry informationi

Entry nameiCTR1_SOLIN
AccessioniPrimary (citable) accession number: Q7SIG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3