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Q7SIG2 (CTR1_SOLIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsin-1

EC=3.4.21.1
Alternative name(s):
Chymotrypsin I
Soli C1
OrganismSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifier13686 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa. Ref.1

Subcellular location

Secretedextracellular space.

Developmental stage

Expressed in fourth instar larvae. Ref.1

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Chymotrypsin-1
PRO_0000248259

Regions

Domain1 – 221221Peptidase S1

Sites

Active site411Charge relay system Ref.2
Active site871Charge relay system Ref.2
Active site1781Charge relay system Ref.2

Amino acid modifications

Disulfide bond26 ↔ 42 Ref.2
Disulfide bond151 ↔ 164 Ref.2
Disulfide bond174 ↔ 198 Ref.2

Secondary structure

...................................... 222
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7SIG2 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 862770BF2A44E652

FASTA22224,012
        10         20         30         40         50         60 
IVGGKDAPVG KYPYQVSLRL SGSHRCGASI LDNNNVLTAA HCVDGLSNLN RLKVHVGTNY 

        70         80         90        100        110        120 
LSESGDVYDV EDAVVNKNYD DFLLRNDVAL VHLTNPIKFN DLVQPIKLST NDEDLESNPC 

       130        140        150        160        170        180 
TLTGWGSTRL GGNTPNALQE IELIVHPQKQ CERDQWRVID SHICTLTKRG EGACHGDSGG 

       190        200        210        220 
PLVANGAQIG IVSFGSPCAL GEPDVYTRVS SFVSWINANL KK 

« Hide

References

[1]"Proteolytic enzymes from larvae of the fire ant, Solenopsis invicta. Isolation and characterization of four serine endopeptidases."
Whitworth S.T., Blum M.S., Travis J.
J. Biol. Chem. 273:14430-14434(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-22, CATALYTIC ACTIVITY, DEVELOPMENTAL STAGE.
Tissue: Larva.
[2]"The structure of an insect chymotrypsin."
Botos I., Meyer E., Nguyen M., Swanson S.M., Koomen J.M., Russell D.H., Meyer E.F.
J. Mol. Biol. 298:895-901(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH INHIBITOR, DISULFIDE BONDS.
Tissue: Larva.

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EQ9X-ray1.70A/B1-222[»]
ProteinModelPortalQ7SIG2.
SMRQ7SIG2. Positions 1-222.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ7SIG2.

Entry information

Entry nameCTR1_SOLIN
AccessionPrimary (citable) accession number: Q7SIG2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references