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Q7SIG2

- CTR1_SOLIN

UniProt

Q7SIG2 - CTR1_SOLIN

Protein

Chymotrypsin-1

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.1 PublicationPROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Charge relay system1 Publication
    Active sitei87 – 871Charge relay system1 Publication
    Active sitei178 – 1781Charge relay system1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.438.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsin-1 (EC:3.4.21.1)
    Alternative name(s):
    Chymotrypsin I
    Soli C1
    OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
    Taxonomic identifieri13686 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Chymotrypsin-1PRO_0000248259Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 421 PublicationPROSITE-ProRule annotation
    Disulfide bondi151 ↔ 1641 PublicationPROSITE-ProRule annotation
    Disulfide bondi174 ↔ 1981 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Developmental stagei

    Expressed in fourth instar larvae.1 Publication

    Structurei

    Secondary structure

    1
    222
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi15 – 206
    Beta strandi23 – 308
    Beta strandi32 – 387
    Helixi40 – 434
    Helixi49 – 513
    Beta strandi52 – 576
    Beta strandi66 – 7510
    Turni81 – 844
    Beta strandi89 – 957
    Beta strandi118 – 1247
    Beta strandi139 – 1468
    Helixi148 – 1547
    Beta strandi155 – 1573
    Beta strandi162 – 1654
    Beta strandi181 – 1844
    Beta strandi187 – 1948
    Turni197 – 1993
    Beta strandi200 – 2023
    Beta strandi204 – 2085
    Helixi209 – 2124
    Helixi213 – 2186

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EQ9X-ray1.70A/B1-222[»]
    ProteinModelPortaliQ7SIG2.
    SMRiQ7SIG2. Positions 1-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7SIG2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 221221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SIG2-1 [UniParc]FASTAAdd to Basket

    « Hide

    IVGGKDAPVG KYPYQVSLRL SGSHRCGASI LDNNNVLTAA HCVDGLSNLN    50
    RLKVHVGTNY LSESGDVYDV EDAVVNKNYD DFLLRNDVAL VHLTNPIKFN 100
    DLVQPIKLST NDEDLESNPC TLTGWGSTRL GGNTPNALQE IELIVHPQKQ 150
    CERDQWRVID SHICTLTKRG EGACHGDSGG PLVANGAQIG IVSFGSPCAL 200
    GEPDVYTRVS SFVSWINANL KK 222
    Length:222
    Mass (Da):24,012
    Last modified:December 15, 2003 - v1
    Checksum:i862770BF2A44E652
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EQ9 X-ray 1.70 A/B 1-222 [» ]
    ProteinModelPortali Q7SIG2.
    SMRi Q7SIG2. Positions 1-222.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q7SIG2.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteolytic enzymes from larvae of the fire ant, Solenopsis invicta. Isolation and characterization of four serine endopeptidases."
      Whitworth S.T., Blum M.S., Travis J.
      J. Biol. Chem. 273:14430-14434(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-22, CATALYTIC ACTIVITY, DEVELOPMENTAL STAGE.
      Tissue: Larva1 Publication.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH INHIBITOR, DISULFIDE BONDS.
      Tissue: Larva1 Publication.

    Entry informationi

    Entry nameiCTR1_SOLIN
    AccessioniPrimary (citable) accession number: Q7SIG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3