Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chymotrypsin-1

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Charge relay system1 Publication1
Active sitei87Charge relay system1 Publication1
Active sitei178Charge relay system1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.1. 6959.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-1 (EC:3.4.21.1)
Alternative name(s):
Chymotrypsin I
Soli C1
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482591 – 222Chymotrypsin-1Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 42PROSITE-ProRule annotation1 Publication
Disulfide bondi151 ↔ 164PROSITE-ProRule annotation1 Publication
Disulfide bondi174 ↔ 198PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ7SIG2.

Expressioni

Developmental stagei

Expressed in fourth instar larvae.1 Publication

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 20Combined sources6
Beta strandi23 – 30Combined sources8
Beta strandi32 – 38Combined sources7
Helixi40 – 43Combined sources4
Helixi49 – 51Combined sources3
Beta strandi52 – 57Combined sources6
Beta strandi66 – 75Combined sources10
Turni81 – 84Combined sources4
Beta strandi89 – 95Combined sources7
Beta strandi118 – 124Combined sources7
Beta strandi139 – 146Combined sources8
Helixi148 – 154Combined sources7
Beta strandi155 – 157Combined sources3
Beta strandi162 – 165Combined sources4
Beta strandi181 – 184Combined sources4
Beta strandi187 – 194Combined sources8
Turni197 – 199Combined sources3
Beta strandi200 – 202Combined sources3
Beta strandi204 – 208Combined sources5
Helixi209 – 212Combined sources4
Helixi213 – 218Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQ9X-ray1.70A/B1-222[»]
ProteinModelPortaliQ7SIG2.
SMRiQ7SIG2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7SIG2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 221Peptidase S1PROSITE-ProRule annotationAdd BLAST221

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SIG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IVGGKDAPVG KYPYQVSLRL SGSHRCGASI LDNNNVLTAA HCVDGLSNLN
60 70 80 90 100
RLKVHVGTNY LSESGDVYDV EDAVVNKNYD DFLLRNDVAL VHLTNPIKFN
110 120 130 140 150
DLVQPIKLST NDEDLESNPC TLTGWGSTRL GGNTPNALQE IELIVHPQKQ
160 170 180 190 200
CERDQWRVID SHICTLTKRG EGACHGDSGG PLVANGAQIG IVSFGSPCAL
210 220
GEPDVYTRVS SFVSWINANL KK
Length:222
Mass (Da):24,012
Last modified:December 15, 2003 - v1
Checksum:i862770BF2A44E652
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQ9X-ray1.70A/B1-222[»]
ProteinModelPortaliQ7SIG2.
SMRiQ7SIG2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7SIG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.21.1. 6959.

Miscellaneous databases

EvolutionaryTraceiQ7SIG2.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTR1_SOLIN
AccessioniPrimary (citable) accession number: Q7SIG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.