Q7SIG1 (Q7SIG1_ALIAC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Hydrolase PDB 1EVQ
Organism	Alicyclobacillus acidocaldarius (Bacillus acidocaldarius) PDB 1EVQ
Taxonomic identifier	1388 [NCBI]
Taxonomic lineage	Bacteria › Firmicutes › Bacillales › Alicyclobacillaceae › Alicyclobacillus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 1EVQ PDB 2HM7 PDB 1QZ3 PDB 1U4N
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7SIG1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: A7F4C7C8A325014F	FASTA	310	34,303
	10 20 30 40 50 60 MPLDPVIQQV LDQLNRMPAP DYKHLSAQQF RSQQSLFPPV KKEPVAEVRE FDMDLPGRTL 70 80 90 100 110 120 KVRMYRPEGV EPPYPALVYY HGGGWVVGDL ETHDPVCRVL AKDGRAVVFS VDYRLAPEHK 130 140 150 160 170 180 FPAAVEDAYD ALQWIAERAA DFHLDPARIA VGGDSAGGNL AAVTSILAKE RGGPALAFQL 190 200 210 220 230 240 LIYPSTGYDP AHPPASIEEN AEGYLLTGGM MLWFRDQYLN SLEELTHPWF SPVLYPDLSG 250 260 270 280 290 300 LPPAYIATAQ YDPLRDVGKL YAEALNKAGV KVEIENFEDL IHGFAQFYSL SPGATKALVR 310 IAEKLRDALA

References

[1]	"A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase." De Simone G., Galdiero S., Manco G., Lang D., Rossi M., Pedone C. J. Mol. Biol. 303:761-771(2000) [PubMed: 11061974] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS).
[2]	"A substrate-induced switch in the reaction mechanism of a thermophilic esterase: kinetic evidences and structural basis." De Simone G., Mandrich L., Menchise V., Giordano V., Febbraio F., Rossi M., Pedone C., Manco G. J. Biol. Chem. 279:6815-6823(2004) [PubMed: 14617621] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
[3]	"Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius." Mandrich L., Menchise V., Alterio V., De Simone G., Pedone C., Rossi M., Manco G. Proteins 71:1721-1731(2008) [PubMed: 18076040] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
[4]	"The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family." De Simone G., Menchise V., Alterio V., Mandrich L., Rossi M., Manco G., Pedone C. J. Mol. Biol. 343:137-146(2004) [PubMed: 15381425] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EVQ	X-ray	2.60	A	1-310	[»]
1QZ3	X-ray	2.30	A	1-310	[»]
1U4N	X-ray	2.10	A	1-310	[»]
2HM7	X-ray	2.00	A	1-310	[»]

ProteinModelPortal

Q7SIG1.

SMR

Q7SIG1. Positions 3-310.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

InterPro

IPR013094. AB_hydrolase_3.
[Graphical view]

Pfam

PF07859. Abhydrolase_3. 1 hit.
[Graphical view]

ProtoNet

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Entry information

Entry name

Q7SIG1_ALIAC

Accession

Primary (citable) accession number: Q7SIG1

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	May 31, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)