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Q7SIE1

- Q7SIE1_LACBR

UniProt

Q7SIE1 - Q7SIE1_LACBR

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Protein
Submitted name:

Hydrolase

Gene
N/A
Organism
Lactobacillus brevis
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei352 – 3521PhosphateImported
Active sitei487 – 4871Proton donor/acceptorImported
Metal bindingi488 – 4881Potassium; via carbonyl oxygenImported
Metal bindingi489 – 4891PotassiumImported
Metal bindingi585 – 5851Potassium; via carbonyl oxygenImported
Metal bindingi586 – 5861Potassium; via carbonyl oxygenImported
Metal bindingi588 – 5881Potassium; via carbonyl oxygenImported
Metal bindingi590 – 5901Potassium; via carbonyl oxygenImported

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. catalytic activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, PotassiumImported

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13019.

Protein family/group databases

CAZyiGH65. Glycoside Hydrolase Family 65.

Names & Taxonomyi

Protein namesi
Submitted name:
HydrolaseImported
OrganismiLactobacillus brevisImported
Taxonomic identifieri1580 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H54X-ray2.15A/B1-754[»]
ProteinModelPortaliQ7SIE1.
SMRiQ7SIE1. Positions 1-743.

Miscellaneous databases

EvolutionaryTraceiQ7SIE1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni627 – 6282Phosphate bindingImported

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
2.70.98.40. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR011013. Gal_mutarotase_SF_dom.
IPR005194. Glyco_hydro_65_C.
IPR005195. Glyco_hydro_65_M.
IPR005196. Glyco_hydro_65_N.
IPR017045. Malt_Pase/Glycosyl_Hdrlase.
[Graphical view]
PfamiPF03633. Glyco_hydro_65C. 1 hit.
PF03632. Glyco_hydro_65m. 1 hit.
PF03636. Glyco_hydro_65N. 1 hit.
[Graphical view]
PIRSFiPIRSF036289. Glycosyl_hydrolase_malt_phosph. 1 hit.
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SIE1-1 [UniParc]FASTAAdd to Basket

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MKRIFEVQPW NVITHTFDPK DKRLQESMTS LGNGYMGMRG DFEEGYSGDS    50
LQGIYLGGVW YPDKTRVGWW KNGYPKYFGK VVNAVNFIKL PIEINGEPVD 100
LAKDKISDFT LDLDMHQGVL NRSFVVERGA VRVALNFQRF LSVAQPELSV 150
QKVTVKNLSD AEVDVTLKPS IDADVMNEEA NYDERFWDVL ATDQQADRGS 200
IVAKTTPNPF GTPRFTSGME MRLVTDLKNV AITQPNEKEV TTAYTGKLAP 250
QASAELEKRV IVVTSRDYDT QESLTAAMHQ LSDKVAQSSY EDLLNAHTAI 300
WAQRWEKSDV VIKGDDESQQ GIRFNLFQLF STYYGEDARL NIGPKGFTGE 350
KYGGATYWDT EAFAFPVYLG ITDPKVTRNL LMYRYKQLDG AYINAQEQGL 400
KGALFPMVTF DGIECHNEWE ITFEEIHRNG DIAFAIYNYT RYTGDDSYVL 450
HEGAKVLTEI SRFWADRVHF SKRNNQYMIH GVTGADEYEN NVDNNWDTNM 500
LAQWTLKYTL EILGKVDQDT AKQLDVSDEE KTKWQDIVDR MYLPYDKDLN 550
IFVQHDGFLD KDIEPVSSIP ADQRPINQNW SWDKILRSPY IKQGDVLQGI 600
WDFIDDYTPE QKKANFDFYE PLTVHESSLS PAIHSVLAAD LHYEDKAVEL 650
YSRTARLDLD NYNNDTTDGL HITSMTGAWI AVVQGFAGMR VRDGQLHYAP 700
FLPKTWTSYT FRQVFRDRLI EVSVHADGPH FKLLSGEPLT IDVAGAAAAA 750
AAAA 754
Length:754
Mass (Da):85,737
Last modified:December 15, 2003 - v1
Checksum:iF959BA54215C9D28
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1H54 X-ray 2.15 A/B 1-754 [» ]
ProteinModelPortali Q7SIE1.
SMRi Q7SIE1. Positions 1-743.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH65. Glycoside Hydrolase Family 65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13019.

Miscellaneous databases

EvolutionaryTracei Q7SIE1.

Family and domain databases

Gene3Di 1.50.10.10. 1 hit.
2.70.98.40. 1 hit.
InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR011013. Gal_mutarotase_SF_dom.
IPR005194. Glyco_hydro_65_C.
IPR005195. Glyco_hydro_65_M.
IPR005196. Glyco_hydro_65_N.
IPR017045. Malt_Pase/Glycosyl_Hdrlase.
[Graphical view ]
Pfami PF03633. Glyco_hydro_65C. 1 hit.
PF03632. Glyco_hydro_65m. 1 hit.
PF03636. Glyco_hydro_65N. 1 hit.
[Graphical view ]
PIRSFi PIRSF036289. Glycosyl_hydrolase_malt_phosph. 1 hit.
SUPFAMi SSF48208. SSF48208. 1 hit.
SSF74650. SSF74650. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Crystal structure of maltose phosphorylase from Lactobacillus brevis: unexpected evolutionary relationship with glucoamylases."
    Egloff M.P., Uppenberg J., Haalck L., van Tilbeurgh H.
    Structure 9:689-697(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH PHOSPHATE AND POTASSIUM, ACTIVE SITE.

Entry informationi

Entry nameiQ7SIE1_LACBR
AccessioniPrimary (citable) accession number: Q7SIE1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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