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Protein
Submitted name:

Hydrolase

Gene
N/A
Organism
Lactobacillus brevis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei487 – 4871Proton donor/acceptorCombined sources

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. catalytic activity Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13019.

Protein family/group databases

CAZyiGH65. Glycoside Hydrolase Family 65.

Names & Taxonomyi

Protein namesi
Submitted name:
HydrolaseImported
OrganismiLactobacillus brevisImported
Taxonomic identifieri1580 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H54X-ray2.15A/B1-754[»]
ProteinModelPortaliQ7SIE1.
SMRiQ7SIE1. Positions 1-743.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7SIE1.

Family & Domainsi

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
2.70.98.40. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR011013. Gal_mutarotase_SF_dom.
IPR005194. Glyco_hydro_65_C.
IPR005195. Glyco_hydro_65_M.
IPR005196. Glyco_hydro_65_N.
IPR017045. Malt_Pase/Glycosyl_Hdrlase.
[Graphical view]
PfamiPF03633. Glyco_hydro_65C. 1 hit.
PF03632. Glyco_hydro_65m. 1 hit.
PF03636. Glyco_hydro_65N. 1 hit.
[Graphical view]
PIRSFiPIRSF036289. Glycosyl_hydrolase_malt_phosph. 1 hit.
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SIE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRIFEVQPW NVITHTFDPK DKRLQESMTS LGNGYMGMRG DFEEGYSGDS
60 70 80 90 100
LQGIYLGGVW YPDKTRVGWW KNGYPKYFGK VVNAVNFIKL PIEINGEPVD
110 120 130 140 150
LAKDKISDFT LDLDMHQGVL NRSFVVERGA VRVALNFQRF LSVAQPELSV
160 170 180 190 200
QKVTVKNLSD AEVDVTLKPS IDADVMNEEA NYDERFWDVL ATDQQADRGS
210 220 230 240 250
IVAKTTPNPF GTPRFTSGME MRLVTDLKNV AITQPNEKEV TTAYTGKLAP
260 270 280 290 300
QASAELEKRV IVVTSRDYDT QESLTAAMHQ LSDKVAQSSY EDLLNAHTAI
310 320 330 340 350
WAQRWEKSDV VIKGDDESQQ GIRFNLFQLF STYYGEDARL NIGPKGFTGE
360 370 380 390 400
KYGGATYWDT EAFAFPVYLG ITDPKVTRNL LMYRYKQLDG AYINAQEQGL
410 420 430 440 450
KGALFPMVTF DGIECHNEWE ITFEEIHRNG DIAFAIYNYT RYTGDDSYVL
460 470 480 490 500
HEGAKVLTEI SRFWADRVHF SKRNNQYMIH GVTGADEYEN NVDNNWDTNM
510 520 530 540 550
LAQWTLKYTL EILGKVDQDT AKQLDVSDEE KTKWQDIVDR MYLPYDKDLN
560 570 580 590 600
IFVQHDGFLD KDIEPVSSIP ADQRPINQNW SWDKILRSPY IKQGDVLQGI
610 620 630 640 650
WDFIDDYTPE QKKANFDFYE PLTVHESSLS PAIHSVLAAD LHYEDKAVEL
660 670 680 690 700
YSRTARLDLD NYNNDTTDGL HITSMTGAWI AVVQGFAGMR VRDGQLHYAP
710 720 730 740 750
FLPKTWTSYT FRQVFRDRLI EVSVHADGPH FKLLSGEPLT IDVAGAAAAA

AAAA
Length:754
Mass (Da):85,737
Last modified:December 15, 2003 - v1
Checksum:iF959BA54215C9D28
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H54X-ray2.15A/B1-754[»]
ProteinModelPortaliQ7SIE1.
SMRiQ7SIE1. Positions 1-743.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH65. Glycoside Hydrolase Family 65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13019.

Miscellaneous databases

EvolutionaryTraceiQ7SIE1.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
2.70.98.40. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR011013. Gal_mutarotase_SF_dom.
IPR005194. Glyco_hydro_65_C.
IPR005195. Glyco_hydro_65_M.
IPR005196. Glyco_hydro_65_N.
IPR017045. Malt_Pase/Glycosyl_Hdrlase.
[Graphical view]
PfamiPF03633. Glyco_hydro_65C. 1 hit.
PF03632. Glyco_hydro_65m. 1 hit.
PF03636. Glyco_hydro_65N. 1 hit.
[Graphical view]
PIRSFiPIRSF036289. Glycosyl_hydrolase_malt_phosph. 1 hit.
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF74650. SSF74650. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Crystal structure of maltose phosphorylase from Lactobacillus brevis: unexpected evolutionary relationship with glucoamylases."
    Egloff M.P., Uppenberg J., Haalck L., van Tilbeurgh H.
    Structure 9:689-697(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS), ACTIVE SITE.

Entry informationi

Entry nameiQ7SIE1_LACBR
AccessioniPrimary (citable) accession number: Q7SIE1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.