Q7SID7 (LYS_ANTMY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Lysozyme EC=3.2.1.17 Alternative name(s): 1,4-beta-N-acetylmuramidase
Organism	Antheraea mylitta (Tasar silkworm)
Taxonomic identifier	34739 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Bombycoidea › Saturniidae › Saturniinae › Saturniini › Antheraea

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer. Ref.1
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 120

120

Lysozyme

PRO_0000235825

Sites

Active site

32

1

By similarity UniProtKB P00698

Active site

50

1

By similarity UniProtKB P00698

Amino acid modifications

Disulfide bond

6 ↔ 120

Ref.1

Disulfide bond

27 ↔ 110

Ref.1

Disulfide bond

62 ↔ 76

Ref.1

Disulfide bond

72 ↔ 90

Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

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120

Helix Strand Turn

Details...

Helix

5 – 14

10

Helix

19 – 21

3

Helix

22 – 32

11

Turn

33 – 35

3

Beta strand

36 – 38

3

Beta strand

45 – 47

3

Turn

52 – 55

4

Turn

58 – 61

4

Beta strand

62 – 67

6

Helix

76 – 80

5

Beta strand

81 – 83

3

Helix

85 – 98

14

Turn

99 – 102

4

Helix

104 – 109

6

Beta strand

110 – 112

3

Sequences

	Sequence		Length	Mass (Da)
	Q7SID7 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 5705F78312527AE7	FASTA	120	13,741
	10 20 30 40 50 60 KRFTRCGLVN ELRKQGFDEN LMRDWVCLVE NESARYTDKI ANVNKNGSRD YGLFQINDKY 70 80 90 100 110 120 WCSKGSTPGK DCNVTCSQLL TDDITVASTC AKKIYKRTKF DAWSGWDNHC NHSNPDISSC

References

[1]	"Structure of the induced antibacterial protein from tasar silkworm, Antheraea mylitta. Implications to molecular evolution." Jain D., Nair D.T., Swaminathan G.J., Abraham E.G., Nagaraju J., Salunke D.M. J. Biol. Chem. 276:41377-41382(2001) [PubMed: 11522783] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-32, X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1IIZ	X-ray	2.40	A	1-120	[»]

ProteinModelPortal

Q7SID7.

SMR

Q7SID7. Positions 1-120.

ModBase

Search...

Protein family/group databases

CAZy

GH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]

Pfam

PF00062. Lys. 1 hit.
[Graphical view]

PRINTS

PR00137. LYSOZYME.
PR00135. LYZLACT.

SMART

SM00263. LYZ1. 1 hit.
[Graphical view]

SUPFAM

SSF53955. SSF53955. 1 hit.

PROSITE

PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

LYS_ANTMY

Accession

Primary (citable) accession number: Q7SID7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	December 15, 2003
Last modified:	May 31, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)