Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7SID7 (LYS_ANTMY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
OrganismAntheraea mylitta (Tasar silkworm)
Taxonomic identifier34739 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSaturniidaeSaturniinaeSaturniiniAntheraea

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subunit structure

Monomer. Ref.1

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 120120Lysozyme
PRO_0000235825

Sites

Active site321 By similarity UniProtKB P00698
Active site501 By similarity UniProtKB P00698

Amino acid modifications

Disulfide bond6 ↔ 120 Ref.1
Disulfide bond27 ↔ 110 Ref.1
Disulfide bond62 ↔ 76 Ref.1
Disulfide bond72 ↔ 90 Ref.1

Secondary structure

........................ 120
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7SID7 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 5705F78312527AE7

FASTA12013,741
        10         20         30         40         50         60 
KRFTRCGLVN ELRKQGFDEN LMRDWVCLVE NESARYTDKI ANVNKNGSRD YGLFQINDKY 

        70         80         90        100        110        120 
WCSKGSTPGK DCNVTCSQLL TDDITVASTC AKKIYKRTKF DAWSGWDNHC NHSNPDISSC 

« Hide

References

[1]"Structure of the induced antibacterial protein from tasar silkworm, Antheraea mylitta. Implications to molecular evolution."
Jain D., Nair D.T., Swaminathan G.J., Abraham E.G., Nagaraju J., Salunke D.M.
J. Biol. Chem. 276:41377-41382(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-32, X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1IIZX-ray2.40A1-120[»]
ProteinModelPortalQ7SID7.
SMRQ7SID7. Positions 1-120.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ7SID7.

Entry information

Entry nameLYS_ANTMY
AccessionPrimary (citable) accession number: Q7SID7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 15, 2003
Last modified: October 16, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries