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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei304Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-2028-MONOMER
UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:TTHB048
Encoded oniPlasmid pTT270 Publication
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Plasmid pTT27

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670741 – 335Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST335

Proteomic databases

PRIDEiQ7SIC7

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 14Combined sources12
Beta strandi16 – 18Combined sources3
Turni20 – 23Combined sources4
Helixi24 – 37Combined sources14
Beta strandi47 – 54Combined sources8
Helixi57 – 61Combined sources5
Helixi70 – 79Combined sources10
Helixi84 – 91Combined sources8
Beta strandi94 – 102Combined sources9
Beta strandi113 – 115Combined sources3
Beta strandi119 – 121Combined sources3
Turni125 – 127Combined sources3
Helixi133 – 152Combined sources20
Beta strandi156 – 163Combined sources8
Helixi167 – 179Combined sources13
Helixi183 – 186Combined sources4
Turni190 – 192Combined sources3
Helixi195 – 210Combined sources16
Helixi218 – 225Combined sources8
Helixi228 – 242Combined sources15
Beta strandi247 – 249Combined sources3
Helixi252 – 264Combined sources13
Helixi266 – 271Combined sources6
Beta strandi272 – 274Combined sources3
Helixi282 – 290Combined sources9
Helixi306 – 321Combined sources16
Helixi327 – 330Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J33X-ray2.00A1-335[»]
1WX1X-ray1.97A/B1-335[»]
ProteinModelPortaliQ7SIC7
SMRiQ7SIC7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7SIC7

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263499
KOiK00768
OMAiATFGGFE
PhylomeDBiQ7SIC7

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

Q7SIC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEVFAQAR LRMDQLTKPP RALGYLEEVA LRLAALQGRV KPELGRGAVV
60 70 80 90 100
VAAADHGVVA EGVSAYPQEV TRQMVLNFLR GGAAINQFAL AADCAVYVLD
110 120 130 140 150
VGVVGELPDH PGLLKRKVRP GTANLAQGPA MTPEEAERAL LAGREAARRA
160 170 180 190 200
IAEGATLLAA GDMGIGNTTA AAALTAALLG LPPEAVVGRG TGVGEEGLRR
210 220 230 240 250
KRQAVARALA RLHPGMGPLE VAAEVGGLEL VAIAGIYLEG YEAGLPLVLD
260 270 280 290 300
GFPVTAGALL AWKMAPGLRD HLFAGHLSRE PGHRHQLEAL GLRPLLDLDL
310 320 330
ALGEGTGAVL AMPLLRAAAR ILHMATFQEA GVSRG
Length:335
Mass (Da):34,747
Last modified:June 7, 2005 - v2
Checksum:iB05DDF144305C4C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008227 Genomic DNA Translation: BAD71844.1
RefSeqiWP_008631396.1, NC_006462.1
YP_145287.1, NC_006462.1

Genome annotation databases

EnsemblBacteriaiBAD71844; BAD71844; BAD71844
GeneIDi3169236
KEGGittj:TTHB048
PATRICifig|300852.9.peg.1992

Similar proteinsi

Entry informationi

Entry nameiCOBT_THET8
AccessioniPrimary (citable) accession number: Q7SIC7
Secondary accession number(s): Q53WB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

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