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Q7SI94 (ARGD_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetylornithine/acetyl-lysine aminotransferase
Short name=ACOAT
EC=2.6.1.-
EC=2.6.1.11
Gene names
Name:argD
Synonyms:lysJ
Ordered Locus Names:SSO0160
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP MF_01107

Catalytic activity

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP MF_01107

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate. HAMAP MF_01107

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_01107

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. HAMAP MF_01107

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5. HAMAP MF_01107

Subunit structure

Homodimer By similarity. HAMAP MF_01107

Subcellular location

Cytoplasm Probable HAMAP MF_01107.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Sequence caution

The sequence AAK40506.1 differs from that shown. Reason: Erroneous initiation.

The sequence DAA00054.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Acetylornithine/acetyl-lysine aminotransferase HAMAP MF_01107
PRO_0000112830

Regions

Region208 – 2114Pyridoxal phosphate binding By similarity

Sites

Binding site1241Pyridoxal phosphate; via carbonyl oxygen By similarity
Binding site1271N2-acetyl-L-ornithine By similarity
Binding site2651N2-acetyl-L-ornithine By similarity
Binding site2661Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2371N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7SI94 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: E0A2368FDB6E80F2

FASTA38843,323
        10         20         30         40         50         60 
MIKLLKFYQD RGIKIIKGEG QYVWDEKNNK YLDMHAGHGV AFLGHRNKVI IDHLKKQMEE 

        70         80         90        100        110        120 
ISTLSLAFDT PIREEMIKEL DELKPEDLDN LFLLNSGSEA VELALKIARK ITKRRKIVAF 

       130        140        150        160        170        180 
KNSFHGRSMG ALSVTWNKKY REPFEPLIGP VEFLEYNNVD SLKSITEDTA AVIVEPVQGE 

       190        200        210        220        230        240 
GGVIPAKKEF VKSLREVTEK VNALLIIDEV QTGFGRTGKI WAYQHFDIKP DILTAGKAIG 

       250        260        270        280        290        300 
GGFPVSAVFL PNWISEKIEE GDHGSTYGGN PLAAAAVTAA CKVAKSEKIA EQAQKKGELF 

       310        320        330        340        350        360 
MRILKEKLED FKIVREIRGL GLMIGIDLKV NPSIAIKVLQ DEKVLSLKAG LTTIRFLPPY 

       370        380 
LITQSDMEWA SDATRKGISE TESKRVAS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006641 Genomic DNA. Translation: AAK40506.1. Different initiation.
BK000545 Genomic DNA. Translation: DAA00054.1. Different initiation.
PIRC90156.
RefSeqNP_341716.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ7SI94.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1453333.
GenomeReviewsGene locus SSO0160 in contig AE006641_GR.
KEGGsso:SSO0160.
NMPDRfig|273057.1.peg.139.

Phylogenomic databases

HOGENOMHBG725944.
OMAVEPVEFI.
ProtClustDBCLSK883609.

Enzyme and pathway databases

BioCycSSOL273057:SSO0160-MONOMER.

Family and domain databases

HAMAPMF_01107. ArgD_aminotrans_3.
[Tree]
InterProIPR004636. AcOrn/SuccinylOrn_aminoTrfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KOK05830.
PANTHERPTHR11986. Aminotrans_3. 1 hit.
PTHR11986:SF19. ArgD_aminotrans. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR00707. ArgD. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGD_SULSO
AccessionPrimary (citable) accession number: Q7SI94
Secondary accession number(s): Q980W6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 5, 2009
Last modified: December 14, 2011
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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