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Q7SHZ2

- GATA_NEUCR

UniProt

Q7SHZ2 - GATA_NEUCR

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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Gene
NCU00660
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Charge relay system By similarity
Active sitei143 – 1431Charge relay system By similarity
Active sitei167 – 1671Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutaminyl-tRNAGln biosynthesis via transamidation Source: UniProtKB-HAMAP
  2. mitochondrial translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (EC:6.3.5.7)
Short name:
Glu-AdT subunit A
Gene namesi
ORF Names:NCU00660
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. glutamyl-tRNA(Gln) amidotransferase complex Source: UniProtKB-HAMAP
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialUniRule annotationPRO_0000413356Add
BLAST

Interactioni

Subunit structurei

Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits By similarity.

Protein-protein interaction databases

STRINGi5141.NCU00660.1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0154.
HOGENOMiHOG000116699.
KOiK02433.
OrthoDBiEOG7P8PJ3.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 2 hits.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SHZ2-1 [UniParc]FASTAAdd to Basket

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MSARIGRLRG LCLRHVSSTR QTSPIQRRSL NQFISRVQQH DQPALEQRQF    50
RLAVKDNIAT VSPNSEEETP LTTTCGSNFL ANYRSPFEAT IVSQLRSRGA 100
LLVGKTNLDE FGMGSHSVHT AFGAVAQEGE HEQQAVKHSA GGSSGGSAVA 150
VATGEADIAL GTDTGGSVRL PAGYTGVVGF KPSYGMLSRY GVVPYANSLD 200
TVGLLAKEVR PIAELILGGA DKVTRGLWAE HDPLDPTSLS HGARRRCASQ 250
RDCYTGPLPK DPYPLKNLKF GLPLEYNITE LSPSIRHSWS AAAAKLQSLG 300
ARLVPVSLPS TRHALSAYYV IAPAEASSNL AKYDGIRYGT RFTSPTESDA 350
AISEGPEGRE EEEEGILYAR ARTAGFGDEV KRRILLGAYT LSSAAMDNYF 400
LKAQKVRRLV RRDFNRVFAL PNPLLDKPER FELSELPETV GLEDKWGPTE 450
VDFLLCPTAP TTAPRLDEVL SEEEKDPVSA YMNDVFTVPA SLAGLPAISV 500
PMRVEDKEGA GMAGLQLIGQ YWDDARLLAV AETVADVVRE EL 542
Length:542
Mass (Da):58,740
Last modified:February 19, 2014 - v2
Checksum:iE7EA772A51C082A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36564.2.
RefSeqiXP_965800.1. XM_960707.1.
UniGeneiNcr.25891.

Genome annotation databases

EnsemblFungiiEFNCRT00000000714; EFNCRP00000000714; EFNCRG00000000714.
GeneIDi3881925.
KEGGincr:NCU00660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36564.2 .
RefSeqi XP_965800.1. XM_960707.1.
UniGenei Ncr.25891.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU00660.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000000714 ; EFNCRP00000000714 ; EFNCRG00000000714 .
GeneIDi 3881925.
KEGGi ncr:NCU00660.

Phylogenomic databases

eggNOGi COG0154.
HOGENOMi HOG000116699.
KOi K02433.
OrthoDBi EOG7P8PJ3.

Family and domain databases

Gene3Di 3.90.1300.10. 1 hit.
HAMAPi MF_00120. GatA.
InterProi IPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view ]
PANTHERi PTHR11895. PTHR11895. 1 hit.
Pfami PF01425. Amidase. 1 hit.
[Graphical view ]
SUPFAMi SSF75304. SSF75304. 2 hits.
PROSITEi PS00571. AMIDASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiGATA_NEUCR
AccessioniPrimary (citable) accession number: Q7SHZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: February 19, 2014
Last modified: July 9, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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