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Q7SHZ2

- GATA_NEUCR

UniProt

Q7SHZ2 - GATA_NEUCR

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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Gene

NCU00660

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Charge relay systemUniRule annotation
Active sitei143 – 1431Charge relay systemUniRule annotation
Active sitei167 – 1671Acyl-ester intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutaminyl-tRNAGln biosynthesis via transamidation Source: UniProtKB-HAMAP
  2. mitochondrial translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-AdT subunit AUniRule annotation
Gene namesi
ORF Names:NCU00660
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Mitochondrion UniRule annotation

GO - Cellular componenti

  1. glutamyl-tRNA(Gln) amidotransferase complex Source: UniProtKB-HAMAP
  2. mitochondrion Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialPRO_0000413356Add
BLAST

Interactioni

Subunit structurei

Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.UniRule annotation

Protein-protein interaction databases

STRINGi5141.NCU00660.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0154.
HOGENOMiHOG000116699.
InParanoidiQ7SHZ2.
KOiK02433.
OrthoDBiEOG7P8PJ3.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 2 hits.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SHZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSARIGRLRG LCLRHVSSTR QTSPIQRRSL NQFISRVQQH DQPALEQRQF
60 70 80 90 100
RLAVKDNIAT VSPNSEEETP LTTTCGSNFL ANYRSPFEAT IVSQLRSRGA
110 120 130 140 150
LLVGKTNLDE FGMGSHSVHT AFGAVAQEGE HEQQAVKHSA GGSSGGSAVA
160 170 180 190 200
VATGEADIAL GTDTGGSVRL PAGYTGVVGF KPSYGMLSRY GVVPYANSLD
210 220 230 240 250
TVGLLAKEVR PIAELILGGA DKVTRGLWAE HDPLDPTSLS HGARRRCASQ
260 270 280 290 300
RDCYTGPLPK DPYPLKNLKF GLPLEYNITE LSPSIRHSWS AAAAKLQSLG
310 320 330 340 350
ARLVPVSLPS TRHALSAYYV IAPAEASSNL AKYDGIRYGT RFTSPTESDA
360 370 380 390 400
AISEGPEGRE EEEEGILYAR ARTAGFGDEV KRRILLGAYT LSSAAMDNYF
410 420 430 440 450
LKAQKVRRLV RRDFNRVFAL PNPLLDKPER FELSELPETV GLEDKWGPTE
460 470 480 490 500
VDFLLCPTAP TTAPRLDEVL SEEEKDPVSA YMNDVFTVPA SLAGLPAISV
510 520 530 540
PMRVEDKEGA GMAGLQLIGQ YWDDARLLAV AETVADVVRE EL
Length:542
Mass (Da):58,740
Last modified:February 19, 2014 - v2
Checksum:iE7EA772A51C082A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36564.2.
RefSeqiXP_965800.1. XM_960707.1.
UniGeneiNcr.25891.

Genome annotation databases

EnsemblFungiiEFNCRT00000000714; EFNCRP00000000714; EFNCRG00000000714.
GeneIDi3881925.
KEGGincr:NCU00660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36564.2 .
RefSeqi XP_965800.1. XM_960707.1.
UniGenei Ncr.25891.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU00660.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000000714 ; EFNCRP00000000714 ; EFNCRG00000000714 .
GeneIDi 3881925.
KEGGi ncr:NCU00660.

Phylogenomic databases

eggNOGi COG0154.
HOGENOMi HOG000116699.
InParanoidi Q7SHZ2.
KOi K02433.
OrthoDBi EOG7P8PJ3.

Family and domain databases

Gene3Di 3.90.1300.10. 1 hit.
HAMAPi MF_00120. GatA.
InterProi IPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view ]
PANTHERi PTHR11895. PTHR11895. 1 hit.
Pfami PF01425. Amidase. 1 hit.
[Graphical view ]
SUPFAMi SSF75304. SSF75304. 2 hits.
PROSITEi PS00571. AMIDASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiGATA_NEUCR
AccessioniPrimary (citable) accession number: Q7SHZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: February 19, 2014
Last modified: October 29, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3