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Q7SHZ2

- GATA_NEUCR

UniProt

Q7SHZ2 - GATA_NEUCR

Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Gene

NCU00660

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (19 Feb 2014)
      Previous versions | rss
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    Functioni

    Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei55 – 551Charge relay systemUniRule annotation
    Active sitei143 – 1431Charge relay systemUniRule annotation
    Active sitei167 – 1671Acyl-ester intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutaminyl-tRNAGln biosynthesis via transamidation Source: UniProtKB-HAMAP
    2. mitochondrial translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialUniRule annotation (EC:6.3.5.7UniRule annotation)
    Short name:
    Glu-AdT subunit AUniRule annotation
    Gene namesi
    ORF Names:NCU00660
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    Mitochondrion UniRule annotation

    GO - Cellular componenti

    1. glutamyl-tRNA(Gln) amidotransferase complex Source: UniProtKB-HAMAP
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialPRO_0000413356Add
    BLAST

    Interactioni

    Subunit structurei

    Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi5141.NCU00660.1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the amidase family. GatA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0154.
    HOGENOMiHOG000116699.
    KOiK02433.
    OrthoDBiEOG7P8PJ3.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    HAMAPiMF_00120. GatA.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 2 hits.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SHZ2-1 [UniParc]FASTAAdd to Basket

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    MSARIGRLRG LCLRHVSSTR QTSPIQRRSL NQFISRVQQH DQPALEQRQF    50
    RLAVKDNIAT VSPNSEEETP LTTTCGSNFL ANYRSPFEAT IVSQLRSRGA 100
    LLVGKTNLDE FGMGSHSVHT AFGAVAQEGE HEQQAVKHSA GGSSGGSAVA 150
    VATGEADIAL GTDTGGSVRL PAGYTGVVGF KPSYGMLSRY GVVPYANSLD 200
    TVGLLAKEVR PIAELILGGA DKVTRGLWAE HDPLDPTSLS HGARRRCASQ 250
    RDCYTGPLPK DPYPLKNLKF GLPLEYNITE LSPSIRHSWS AAAAKLQSLG 300
    ARLVPVSLPS TRHALSAYYV IAPAEASSNL AKYDGIRYGT RFTSPTESDA 350
    AISEGPEGRE EEEEGILYAR ARTAGFGDEV KRRILLGAYT LSSAAMDNYF 400
    LKAQKVRRLV RRDFNRVFAL PNPLLDKPER FELSELPETV GLEDKWGPTE 450
    VDFLLCPTAP TTAPRLDEVL SEEEKDPVSA YMNDVFTVPA SLAGLPAISV 500
    PMRVEDKEGA GMAGLQLIGQ YWDDARLLAV AETVADVVRE EL 542
    Length:542
    Mass (Da):58,740
    Last modified:February 19, 2014 - v2
    Checksum:iE7EA772A51C082A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36564.2.
    RefSeqiXP_965800.1. XM_960707.1.
    UniGeneiNcr.25891.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000000714; EFNCRP00000000714; EFNCRG00000000714.
    GeneIDi3881925.
    KEGGincr:NCU00660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36564.2 .
    RefSeqi XP_965800.1. XM_960707.1.
    UniGenei Ncr.25891.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU00660.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000000714 ; EFNCRP00000000714 ; EFNCRG00000000714 .
    GeneIDi 3881925.
    KEGGi ncr:NCU00660.

    Phylogenomic databases

    eggNOGi COG0154.
    HOGENOMi HOG000116699.
    KOi K02433.
    OrthoDBi EOG7P8PJ3.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    HAMAPi MF_00120. GatA.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 2 hits.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiGATA_NEUCR
    AccessioniPrimary (citable) accession number: Q7SHZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: February 19, 2014
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3