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Q7SHX5

- Q7SHX5_NEUCR

UniProt

Q7SHX5 - Q7SHX5_NEUCR

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Protein

Glutamate decarboxylase

Gene

NCU00678

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
ORF Names:NCU00678Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU00678.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiQ7SHX5.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SHX5 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSLSRHVDPE EIIHHLKDIK LQEKGSGSQR QNHLTPYNSS YASQEDIPKY
60 70 80 90 100
KIPENGTPGD TVYAMLRDEL DLDGRPNLNM ASFVNTYIEK DAQKLFVENL
110 120 130 140 150
GKNLSDNDEY PAMISFSDRC VSILAHLWGV QKGEKAIGTA TVGSSEAVHL
160 170 180 190 200
GGLAMKRRWQ EKRRAEGKDA YKPNIIMGAN AQVALEKFAR YFDVEARILP
210 220 230 240 250
VSAQSNYCLD PALVKENLDE NTIGVFVILG STYTGHYEPV EEIHKILDDF
260 270 280 290 300
ESQTGIDIPI HVDAASGGFV APFTYAKTGG HKWNFELPRV KSINVSGHKY
310 320 330 340 350
GLVTPGVGWI VWRDESFLPK HLIFELHYLG GTEYSYTLNF SRPGAQVIVQ
360 370 380 390 400
YYNLIHLGFQ GYRAVVENCL SNARLLSKAL EATGWYTCVS DIHRPPQKQA
410 420 430 440 450
GSVKSGSSGY DGENDQSCCS ESQNDDQKAE SEESKTHASS SSLSSSKDTP
460 470 480 490 500
ETDRNREETS ADYTPGLPVV SFRFTDEFQQ EYPHVKQETV SLLMRARQWI
510 520 530 540 550
IPNYALPPNE DQTEILRVVI RESFSFDLID RLVTDLVSVT ETLMENDEVD
560 570 580 590 600
LSLLQQHQGG RRRPLTKDEK RIEKEERERE ERKGEERGEE KGKRMGEGIH

RSVC
Length:604
Mass (Da):68,121
Last modified:January 22, 2014 - v3
Checksum:i3C4C60BE236BA989
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36582.3.
RefSeqiXP_965818.2. XM_960725.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000000954; EFNCRP00000000954; EFNCRG00000000953.
GeneIDi3881943.
KEGGincr:NCU11190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36582.3 .
RefSeqi XP_965818.2. XM_960725.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU00678.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000000954 ; EFNCRP00000000954 ; EFNCRG00000000953 .
GeneIDi 3881943.
KEGGi ncr:NCU11190.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
InParanoidi Q7SHX5.
KOi K01580.
OrthoDBi EOG7P2Z22.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 2 hits.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

Entry informationi

Entry nameiQ7SHX5_NEUCR
AccessioniPrimary (citable) accession number: Q7SHX5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 22, 2014
Last modified: October 29, 2014
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3