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Protein

Glutamate decarboxylase

Gene

NCU00678

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
ORF Names:NCU00678Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805 Componenti: Chromosome 1, Linkage Group I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiQ7SHX5.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SHX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSRHVDPE EIIHHLKDIK LQEKGSGSQR QNHLTPYNSS YASQEDIPKY
60 70 80 90 100
KIPENGTPGD TVYAMLRDEL DLDGRPNLNM ASFVNTYIEK DAQKLFVENL
110 120 130 140 150
GKNLSDNDEY PAMISFSDRC VSILAHLWGV QKGEKAIGTA TVGSSEAVHL
160 170 180 190 200
GGLAMKRRWQ EKRRAEGKDA YKPNIIMGAN AQVALEKFAR YFDVEARILP
210 220 230 240 250
VSAQSNYCLD PALVKENLDE NTIGVFVILG STYTGHYEPV EEIHKILDDF
260 270 280 290 300
ESQTGIDIPI HVDAASGGFV APFTYAKTGG HKWNFELPRV KSINVSGHKY
310 320 330 340 350
GLVTPGVGWI VWRDESFLPK HLIFELHYLG GTEYSYTLNF SRPGAQVIVQ
360 370 380 390 400
YYNLIHLGFQ GYRAVVENCL SNARLLSKAL EATGWYTCVS DIHRPPQKQA
410 420 430 440 450
GSVKSGSSGY DGENDQSCCS ESQNDDQKAE SEESKTHASS SSLSSSKDTP
460 470 480 490 500
ETDRNREETS ADYTPGLPVV SFRFTDEFQQ EYPHVKQETV SLLMRARQWI
510 520 530 540 550
IPNYALPPNE DQTEILRVVI RESFSFDLID RLVTDLVSVT ETLMENDEVD
560 570 580 590 600
LSLLQQHQGG RRRPLTKDEK RIEKEERERE ERKGEERGEE KGKRMGEGIH

RSVC
Length:604
Mass (Da):68,121
Last modified:January 22, 2014 - v3
Checksum:i3C4C60BE236BA989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA36582.3.
RefSeqiXP_965818.3. XM_960725.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000000954; EFNCRP00000000954; EFNCRG00000000953.
GeneIDi23568347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA36582.3.
RefSeqiXP_965818.3. XM_960725.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000000954; EFNCRP00000000954; EFNCRG00000000953.
GeneIDi23568347.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiQ7SHX5.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

Entry informationi

Entry nameiQ7SHX5_NEUCR
AccessioniPrimary (citable) accession number: Q7SHX5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 22, 2014
Last modified: July 22, 2015
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.