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Q7SHX5

- Q7SHX5_NEUCR

UniProt

Q7SHX5 - Q7SHX5_NEUCR

Protein

Glutamate decarboxylase

Gene

NCU00678

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 3 (22 Jan 2014)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    ORF Names:NCU00678Imported
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU00678.1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OrthoDBiEOG7P2Z22.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 2 hits.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7SHX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSRHVDPE EIIHHLKDIK LQEKGSGSQR QNHLTPYNSS YASQEDIPKY    50
    KIPENGTPGD TVYAMLRDEL DLDGRPNLNM ASFVNTYIEK DAQKLFVENL 100
    GKNLSDNDEY PAMISFSDRC VSILAHLWGV QKGEKAIGTA TVGSSEAVHL 150
    GGLAMKRRWQ EKRRAEGKDA YKPNIIMGAN AQVALEKFAR YFDVEARILP 200
    VSAQSNYCLD PALVKENLDE NTIGVFVILG STYTGHYEPV EEIHKILDDF 250
    ESQTGIDIPI HVDAASGGFV APFTYAKTGG HKWNFELPRV KSINVSGHKY 300
    GLVTPGVGWI VWRDESFLPK HLIFELHYLG GTEYSYTLNF SRPGAQVIVQ 350
    YYNLIHLGFQ GYRAVVENCL SNARLLSKAL EATGWYTCVS DIHRPPQKQA 400
    GSVKSGSSGY DGENDQSCCS ESQNDDQKAE SEESKTHASS SSLSSSKDTP 450
    ETDRNREETS ADYTPGLPVV SFRFTDEFQQ EYPHVKQETV SLLMRARQWI 500
    IPNYALPPNE DQTEILRVVI RESFSFDLID RLVTDLVSVT ETLMENDEVD 550
    LSLLQQHQGG RRRPLTKDEK RIEKEERERE ERKGEERGEE KGKRMGEGIH 600
    RSVC 604
    Length:604
    Mass (Da):68,121
    Last modified:January 22, 2014 - v3
    Checksum:i3C4C60BE236BA989
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36582.3.
    RefSeqiXP_965818.2. XM_960725.2.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000000954; EFNCRP00000000954; EFNCRG00000000953.
    GeneIDi3881943.
    KEGGincr:NCU11190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36582.3 .
    RefSeqi XP_965818.2. XM_960725.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU00678.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000000954 ; EFNCRP00000000954 ; EFNCRG00000000953 .
    GeneIDi 3881943.
    KEGGi ncr:NCU11190.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OrthoDBi EOG7P2Z22.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 2 hits.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

    Entry informationi

    Entry nameiQ7SHX5_NEUCR
    AccessioniPrimary (citable) accession number: Q7SHX5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2003
    Last sequence update: January 22, 2014
    Last modified: October 1, 2014
    This is version 65 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3