Q7SHU8 (DAPB_NEUCR) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 59.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable dipeptidyl-aminopeptidase B Short name=DPAP B EC=3.4.14.5 | ||||
| Gene names |
| ||||
| Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome] | ||||
| Taxonomic identifier | 367110 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora ›  |
Protein attributes
| Sequence length | 895 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity. |
| Catalytic activity | Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. |
| Subcellular location | Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity. |
| Sequence similarities | Belongs to the peptidase S9B family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane Vacuole |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Aminopeptidase Hydrolase Protease Serine protease |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | proteolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW vacuolar membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 895 | 895 | Probable dipeptidyl-aminopeptidase B | PRO_0000412152 | |||||
Regions | |||||||||
| Topological domain | 1 – 82 | 82 | Cytoplasmic Potential | ||||||
| Transmembrane | 83 – 103 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||
| Topological domain | 104 – 895 | 792 | Vacuolar Potential | ||||||
Sites | |||||||||
| Active site | 739 | 1 | Charge relay system By similarity | ||||||
| Active site | 816 | 1 | Charge relay system By similarity | ||||||
| Active site | 849 | 1 | Charge relay system By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 202 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 335 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 798 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.  Birren B.W.Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AABX02000006 Genomic DNA. Translation: EAA36410.1. |
| RefSeq | XP_965646.1. XM_960553.1. |
| UniGene | Ncr.16123. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NU6 based on UniProtKB P27487. |
| ProteinModelPortal | Q7SHU8. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 5141.NCU02515.1. |
Protein family/group databases | |
| MEROPS | S09.006. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | EFNCRT00000002047; EFNCRP00000002047; EFNCRG00000002045. |
| GeneID | 3881844. |
| KEGG | ncr:NCU02515. |
Phylogenomic databases | |
| eggNOG | COG1506. |
| HOGENOM | HOG000189891. |
| KO | K01282. |
| OrthoDB | EOG4Q885J. |
Family and domain databases | |
| InterPro | IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view] |
| Pfam | PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view] |
| PROSITE | PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DAPB_NEUCR | ||||||||
| Accession | Primary (citable) accession number: Q7SHU8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |