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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei768Charge relay systemPROSITE-ProRule annotation1
Active sitei845Charge relay systemPROSITE-ProRule annotation1
Active sitei878Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERineucr-q7shu8 DPP4N_Peptidase_S9
MEROPSiS09.006

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:NCU02515
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU02515

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 111CytoplasmicSequence analysisAdd BLAST111
Transmembranei112 – 132Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini133 – 924VacuolarSequence analysisAdd BLAST792

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121521 – 924Probable dipeptidyl-aminopeptidase BAdd BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891
InParanoidiQ7SHU8
KOiK01282
OrthoDBiEOG092C0PZJ

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002471 Pept_S9_AS
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00708 PRO_ENDOPEP_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q7SHU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTYSDDNT LRSGLDRFRD HSPSQHRRSM SQETDSTVST TSIVFDRIQE
60 70 80 90 100
RLDTKEFPAR GTDGDDNDSL KDELNNDDLE TGPFLGNASP SSRSNQRSSA
110 120 130 140 150
DGQRMDRSLR RWLFIVSGAL VATWVIGLIF FVSSKAYKPS SSFAHDPQAT
160 170 180 190 200
VTHGSGKKVT LDQVLNNEWR AKSHSISWIA GVNGEDGLLL EKEGANKDYL
210 220 230 240 250
VVEDVRAQNP SSVEASKSKT LIKDKLFEFA NKTYWPTVTV PSRDLKKVLL
260 270 280 290 300
ATDVQNNWRH SYYAVYWIFD VETQQAEPLV PYDADARLQL ASWSPTSDAI
310 320 330 340 350
VYTRDNNMFL RKLDSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW
360 370 380 390 400
WSEDGNYVAF LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY
410 420 430 440 450
PKAGAHNPIV DLKFYDVKRG DVFSVDISGR FADDDRLITE VIWAGKQVLI
460 470 480 490 500
KETNRVSDVM RVVLVDVGSR TGKAVRTVDV NDIDGGWFEI SHKTKFIPAD
510 520 530 540 550
PANGRPDDGY VDTIIHNNGD HLAYFTPLDN PNPIMLTSGD YEVVDAPSAV
560 570 580 590 600
DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG
610 620 630 640 650
AGYALVSYQG PNIPWQKVIS TPSNPDKYEH VVEENKDLAE AAKKHELPIN
660 670 680 690 700
IYGTINVDGV ELNYIERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD
710 720 730 740 750
FQSFVAAGLG YICVTVDGRG TGFIGRKNRV IIRGNLGTWE SHDQIAAAKH
760 770 780 790 800
WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ DAGQTFKYGM AVAPVTDWRF
810 820 830 840 850
YDSIYTERYM RTPQTNPEGY ESAAVTNVTA LSQNVRFLLM HGVADDNVHM
860 870 880 890 900
QNSLTLLDAL DQRSVENYDV QVFPDSDHGI YFHNANRIVF DKLTNWLVNA
910 920
FNGEWLKIAN AQPNGMKRRA LPTA
Length:924
Mass (Da):104,094
Last modified:March 19, 2014 - v2
Checksum:iD11B8E601522811D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA Translation: EAA36410.2
RefSeqiXP_965646.2, XM_960553.2

Genome annotation databases

EnsemblFungiiEAA36410; EAA36410; NCU02515
GeneIDi3881844
KEGGincr:NCU02515

Similar proteinsi

Entry informationi

Entry nameiDAPB_NEUCR
AccessioniPrimary (citable) accession number: Q7SHU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 19, 2014
Last modified: March 28, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health