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Q7SHU8

- DAPB_NEUCR

UniProt

Q7SHU8 - DAPB_NEUCR

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei768 – 7681Charge relay systemPROSITE-ProRule annotation
    Active sitei845 – 8451Charge relay systemPROSITE-ProRule annotation
    Active sitei878 – 8781Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:NCU02515
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 924924Probable dipeptidyl-aminopeptidase BPRO_0000412152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU02515.1.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 111111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 924792VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei112 – 13221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    HOGENOMiHOG000189891.
    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SHU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSTYSDDNT LRSGLDRFRD HSPSQHRRSM SQETDSTVST TSIVFDRIQE    50
    RLDTKEFPAR GTDGDDNDSL KDELNNDDLE TGPFLGNASP SSRSNQRSSA 100
    DGQRMDRSLR RWLFIVSGAL VATWVIGLIF FVSSKAYKPS SSFAHDPQAT 150
    VTHGSGKKVT LDQVLNNEWR AKSHSISWIA GVNGEDGLLL EKEGANKDYL 200
    VVEDVRAQNP SSVEASKSKT LIKDKLFEFA NKTYWPTVTV PSRDLKKVLL 250
    ATDVQNNWRH SYYAVYWIFD VETQQAEPLV PYDADARLQL ASWSPTSDAI 300
    VYTRDNNMFL RKLDSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW 350
    WSEDGNYVAF LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY 400
    PKAGAHNPIV DLKFYDVKRG DVFSVDISGR FADDDRLITE VIWAGKQVLI 450
    KETNRVSDVM RVVLVDVGSR TGKAVRTVDV NDIDGGWFEI SHKTKFIPAD 500
    PANGRPDDGY VDTIIHNNGD HLAYFTPLDN PNPIMLTSGD YEVVDAPSAV 550
    DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG 600
    AGYALVSYQG PNIPWQKVIS TPSNPDKYEH VVEENKDLAE AAKKHELPIN 650
    IYGTINVDGV ELNYIERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD 700
    FQSFVAAGLG YICVTVDGRG TGFIGRKNRV IIRGNLGTWE SHDQIAAAKH 750
    WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ DAGQTFKYGM AVAPVTDWRF 800
    YDSIYTERYM RTPQTNPEGY ESAAVTNVTA LSQNVRFLLM HGVADDNVHM 850
    QNSLTLLDAL DQRSVENYDV QVFPDSDHGI YFHNANRIVF DKLTNWLVNA 900
    FNGEWLKIAN AQPNGMKRRA LPTA 924
    Length:924
    Mass (Da):104,094
    Last modified:March 19, 2014 - v2
    Checksum:iD11B8E601522811D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36410.2.
    RefSeqiXP_965646.1. XM_960553.1.
    UniGeneiNcr.16123.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000002047; EFNCRP00000002047; EFNCRG00000002045.
    GeneIDi3881844.
    KEGGincr:NCU02515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36410.2 .
    RefSeqi XP_965646.1. XM_960553.1.
    UniGenei Ncr.16123.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU02515.1.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000002047 ; EFNCRP00000002047 ; EFNCRG00000002045 .
    GeneIDi 3881844.
    KEGGi ncr:NCU02515.

    Phylogenomic databases

    eggNOGi COG1506.
    HOGENOMi HOG000189891.
    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiDAPB_NEUCR
    AccessioniPrimary (citable) accession number: Q7SHU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3