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Q7SHU8

- DAPB_NEUCR

UniProt

Q7SHU8 - DAPB_NEUCR

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, NCU02515
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei768 – 7681Charge relay system By similarity
Active sitei845 – 8451Charge relay system By similarity
Active sitei878 – 8781Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:NCU02515
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 111111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini133 – 924792Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 924924Probable dipeptidyl-aminopeptidase B
PRO_0000412152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi364 – 3641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi827 – 8271N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU02515.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SHU8-1 [UniParc]FASTAAdd to Basket

« Hide

MPSTYSDDNT LRSGLDRFRD HSPSQHRRSM SQETDSTVST TSIVFDRIQE    50
RLDTKEFPAR GTDGDDNDSL KDELNNDDLE TGPFLGNASP SSRSNQRSSA 100
DGQRMDRSLR RWLFIVSGAL VATWVIGLIF FVSSKAYKPS SSFAHDPQAT 150
VTHGSGKKVT LDQVLNNEWR AKSHSISWIA GVNGEDGLLL EKEGANKDYL 200
VVEDVRAQNP SSVEASKSKT LIKDKLFEFA NKTYWPTVTV PSRDLKKVLL 250
ATDVQNNWRH SYYAVYWIFD VETQQAEPLV PYDADARLQL ASWSPTSDAI 300
VYTRDNNMFL RKLDSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW 350
WSEDGNYVAF LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY 400
PKAGAHNPIV DLKFYDVKRG DVFSVDISGR FADDDRLITE VIWAGKQVLI 450
KETNRVSDVM RVVLVDVGSR TGKAVRTVDV NDIDGGWFEI SHKTKFIPAD 500
PANGRPDDGY VDTIIHNNGD HLAYFTPLDN PNPIMLTSGD YEVVDAPSAV 550
DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG 600
AGYALVSYQG PNIPWQKVIS TPSNPDKYEH VVEENKDLAE AAKKHELPIN 650
IYGTINVDGV ELNYIERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD 700
FQSFVAAGLG YICVTVDGRG TGFIGRKNRV IIRGNLGTWE SHDQIAAAKH 750
WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ DAGQTFKYGM AVAPVTDWRF 800
YDSIYTERYM RTPQTNPEGY ESAAVTNVTA LSQNVRFLLM HGVADDNVHM 850
QNSLTLLDAL DQRSVENYDV QVFPDSDHGI YFHNANRIVF DKLTNWLVNA 900
FNGEWLKIAN AQPNGMKRRA LPTA 924
Length:924
Mass (Da):104,094
Last modified:March 19, 2014 - v2
Checksum:iD11B8E601522811D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36410.2.
RefSeqiXP_965646.1. XM_960553.1.
UniGeneiNcr.16123.

Genome annotation databases

EnsemblFungiiEFNCRT00000002047; EFNCRP00000002047; EFNCRG00000002045.
GeneIDi3881844.
KEGGincr:NCU02515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA36410.2 .
RefSeqi XP_965646.1. XM_960553.1.
UniGenei Ncr.16123.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU02515.1.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000002047 ; EFNCRP00000002047 ; EFNCRG00000002045 .
GeneIDi 3881844.
KEGGi ncr:NCU02515.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiDAPB_NEUCR
AccessioniPrimary (citable) accession number: Q7SHU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 19, 2014
Last modified: June 11, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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