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Q7SHU8 (DAPB_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:NCU02515
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length924 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 924924Probable dipeptidyl-aminopeptidase B
PRO_0000412152

Regions

Topological domain1 – 111111Cytoplasmic Potential
Transmembrane112 – 13221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain133 – 924792Vacuolar Potential

Sites

Active site7681Charge relay system By similarity
Active site8451Charge relay system By similarity
Active site8781Charge relay system By similarity

Amino acid modifications

Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation8271N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7SHU8 [UniParc].

Last modified March 19, 2014. Version 2.
Checksum: D11B8E601522811D

FASTA924104,094
        10         20         30         40         50         60 
MPSTYSDDNT LRSGLDRFRD HSPSQHRRSM SQETDSTVST TSIVFDRIQE RLDTKEFPAR 

        70         80         90        100        110        120 
GTDGDDNDSL KDELNNDDLE TGPFLGNASP SSRSNQRSSA DGQRMDRSLR RWLFIVSGAL 

       130        140        150        160        170        180 
VATWVIGLIF FVSSKAYKPS SSFAHDPQAT VTHGSGKKVT LDQVLNNEWR AKSHSISWIA 

       190        200        210        220        230        240 
GVNGEDGLLL EKEGANKDYL VVEDVRAQNP SSVEASKSKT LIKDKLFEFA NKTYWPTVTV 

       250        260        270        280        290        300 
PSRDLKKVLL ATDVQNNWRH SYYAVYWIFD VETQQAEPLV PYDADARLQL ASWSPTSDAI 

       310        320        330        340        350        360 
VYTRDNNMFL RKLDSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW WSEDGNYVAF 

       370        380        390        400        410        420 
LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY PKAGAHNPIV DLKFYDVKRG 

       430        440        450        460        470        480 
DVFSVDISGR FADDDRLITE VIWAGKQVLI KETNRVSDVM RVVLVDVGSR TGKAVRTVDV 

       490        500        510        520        530        540 
NDIDGGWFEI SHKTKFIPAD PANGRPDDGY VDTIIHNNGD HLAYFTPLDN PNPIMLTSGD 

       550        560        570        580        590        600 
YEVVDAPSAV DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG 

       610        620        630        640        650        660 
AGYALVSYQG PNIPWQKVIS TPSNPDKYEH VVEENKDLAE AAKKHELPIN IYGTINVDGV 

       670        680        690        700        710        720 
ELNYIERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD FQSFVAAGLG YICVTVDGRG 

       730        740        750        760        770        780 
TGFIGRKNRV IIRGNLGTWE SHDQIAAAKH WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ 

       790        800        810        820        830        840 
DAGQTFKYGM AVAPVTDWRF YDSIYTERYM RTPQTNPEGY ESAAVTNVTA LSQNVRFLLM 

       850        860        870        880        890        900 
HGVADDNVHM QNSLTLLDAL DQRSVENYDV QVFPDSDHGI YFHNANRIVF DKLTNWLVNA 

       910        920 
FNGEWLKIAN AQPNGMKRRA LPTA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002236 Genomic DNA. Translation: EAA36410.2.
RefSeqXP_965646.1. XM_960553.1.
UniGeneNcr.16123.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU02515.1.

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000002047; EFNCRP00000002047; EFNCRG00000002045.
GeneID3881844.
KEGGncr:NCU02515.

Phylogenomic databases

eggNOGCOG1506.
HOGENOMHOG000189891.
KOK01282.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_NEUCR
AccessionPrimary (citable) accession number: Q7SHU8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 19, 2014
Last modified: June 11, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries