Q7SGY1 (ALO_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative D-arabinono-1,4-lactone oxidase
Short name=ALO
EC=1.1.3.37

Alternative name(s):
L-galactono-gamma-lactone oxidase

Gene names

Name:	alo-1
ORF Names:	NCU03188

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.
Subcellular location	Mitochondrion membrane By similarity. Note: Membrane-embedded By similarity.
Sequence similarities	Belongs to the oxygen-dependent FAD-linked oxidoreductase family. Contains 1 FAD-binding PCMH-type domain.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	D-arabinono-1,4-lactone oxidase activity Inferred from electronic annotation. Source: EC UDP-N-acetylmuramate dehydrogenase activity Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Putative D-arabinono-1,4-lactone oxidase		PRO_0000128168
Regions
	Domain	47 – 217	171	FAD-binding PCMH-type
Amino acid modifications
	Modified residue	84	1	Pros-8alpha-FAD histidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SGY1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 7E8FDCCF866F10ED	FASTA	556	62,600
	10 20 30 40 50 60 MATESNPALA SLPSNVREII ELASQRDGGI PFRAKTAHVH RTWAGTFTSL PELYIQPESV 70 80 90 100 110 120 SEIQKVVRLA RHARRRVTTT GCGHSPSDIT CTSSWLVNLD NFNKVISVDH LTGLVVVQAG 130 140 150 160 170 180 IRLYQLSDEL DRRGLALPSL GSINEQSIAG AISTGTHGSG IKHGLVGESI TELKITLANG 190 200 210 220 230 240 ETLSCSPEDK PDLFRAALIS LGALGIITEV TFKAVPAFSL AWSQAIDSDK RIFEKWEKDL 250 260 270 280 290 300 WSQAEFVRIW WFPYMRRAAV WTANVVDPVD LKTGAVKHRE PPTSYYDSWL GYYVYHNLLA 310 320 330 340 350 360 LSRWIPRITP WIEWFVFGMQ YGFKNGEVTR IGAVQPSQKA FLLNCLYSQS VNEWAIPLHK 370 380 390 400 410 420 GPEALQRLGA WLQNLKPGDP GYVEHGIPYS AEGLWVHSPV EVRASDSTVY TSREANTRPF 430 440 450 460 470 480 LDPTQSDGPT LYLNAIMYRP YHREPTYNAT ERYYLGFEWL MRELGGKPHW AKTFTATQAD 490 500 510 520 530 540 LARWYGDDFQ RWGAVRESVD PEGMFVGPWH RRYLLEPLQR DRLLPLEEIQ QTTKKVPARQ 550 GGGIEVIGIQ NLVAPN

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000009 Genomic DNA. Translation: EAA36052.1.
RefSeq	XP_965288.1. XM_960195.1.
3D structure databases
ProteinModelPortal	Q7SGY1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000002860; EFNCRP00000002860; EFNCRG00000002857.
GeneID	3881437.
KEGG	ncr:NCU03188.
Phylogenomic databases
eggNOG	COG0277.
HOGENOM	HOG000204635.
KO	K00107.
OMA	DCLFSQF.
OrthoDB	EOG4GF6PD.
Enzyme and pathway databases
UniPathway	UPA00771; UER00766.
Family and domain databases
Gene3D	3.30.43.10. 1 hit. 3.30.465.10. 1 hit.
InterPro	IPR007173. ALO. IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR010031. FAD_lactone_oxidase. IPR023595. LGO_GLO. IPR006094. Oxid_FAD_bind_N. IPR006093. Oxy_OxRdtase_FAD_BS. [Graphical view]
Pfam	PF04030. ALO. 1 hit. PF01565. FAD_binding_4. 1 hit. [Graphical view]
PIRSF	PIRSF000136. LGO_GLO. 1 hit.
SUPFAM	SSF56176. FAD-binding_2. 1 hit.
TIGRFAMs	TIGR01678. FAD_lactone_ox. 1 hit.
PROSITE	PS51387. FAD_PCMH. 1 hit. PS00862. OX2_COVAL_FAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALO_NEUCR

Accession

Primary (citable) accession number: Q7SGY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program