Reviewed, UniProtKB/Swiss-Prot Q7SGY1 (ALO_NEUCR)

Names and origin

Protein names

Recommended name:
    Putative D-arabinono-1,4-lactone oxidase
      Short name=ALO
    EC=1.1.3.37
Alternative name(s):
    L-galactono-gamma-lactone oxidase

Gene names

Name:	alo-1
ORF Names:	NCU03188

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2).
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; D-erythroascorbic acid biosynthesis; D-erythro-ascorbic acid from D-arabinose: step 2/2.
Subcellular location	Mitochondrion membraneBy similarity. Note= Membrane-embedded By similarity.
Sequence similarities	Belongs to the oxygen-dependent FAD-linked oxidoreductase family. Contains 1 FAD-binding PCMH-type domain.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-arabinono-1,4-lactone oxidase activity Inferred from electronic annotation. Source: InterPro FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Putative D-arabinono-1,4-lactone oxidase		PRO_0000128168
Regions
	Domain	47 – 217	171	FAD-binding PCMH-type
Amino acid modifications
	Modified residue	84	1	Tele-8alpha-FAD histidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SGY1-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 7E8FDCCF866F10ED	FASTA	556	62,600
	10 20 30 40 50 60 MATESNPALA SLPSNVREII ELASQRDGGI PFRAKTAHVH RTWAGTFTSL PELYIQPESV 70 80 90 100 110 120 SEIQKVVRLA RHARRRVTTT GCGHSPSDIT CTSSWLVNLD NFNKVISVDH LTGLVVVQAG 130 140 150 160 170 180 IRLYQLSDEL DRRGLALPSL GSINEQSIAG AISTGTHGSG IKHGLVGESI TELKITLANG 190 200 210 220 230 240 ETLSCSPEDK PDLFRAALIS LGALGIITEV TFKAVPAFSL AWSQAIDSDK RIFEKWEKDL 250 260 270 280 290 300 WSQAEFVRIW WFPYMRRAAV WTANVVDPVD LKTGAVKHRE PPTSYYDSWL GYYVYHNLLA 310 320 330 340 350 360 LSRWIPRITP WIEWFVFGMQ YGFKNGEVTR IGAVQPSQKA FLLNCLYSQS VNEWAIPLHK 370 380 390 400 410 420 GPEALQRLGA WLQNLKPGDP GYVEHGIPYS AEGLWVHSPV EVRASDSTVY TSREANTRPF 430 440 450 460 470 480 LDPTQSDGPT LYLNAIMYRP YHREPTYNAT ERYYLGFEWL MRELGGKPHW AKTFTATQAD 490 500 510 520 530 540 LARWYGDDFQ RWGAVRESVD PEGMFVGPWH RRYLLEPLQR DRLLPLEEIQ QTTKKVPARQ 550 GGGIEVIGIQ NLVAPN

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AABX02000009 Genomic DNA. Translation: EAA36052.1.
RefSeq	XP_965288.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3881437.
KEGG	ncr:NCU03188.
NMPDR	fig|5141.1.peg.8557.
Family and domain databases
InterPro	IPR007173. ALO. IPR016168. FAD-linked_Oxase_FAD-bd_sub2. IPR010031. FAD_lactone_oxidase. IPR006094. Oxid_FAD_bind_N. IPR006093. Oxy_OxRdtase_FAD_BS. [Graphical view]
Gene3D	G3DSA:3.30.465.20. FAD-linked_oxidase_FAD-bd_sub2. 1 hit.
Pfam	PF04030. ALO. 1 hit. PF01565. FAD_binding_4. 1 hit. [Graphical view]
TIGRFAMs	TIGR01678. FAD_lactone_ox. 1 hit.
PROSITE	PS51387. FAD_PCMH. 1 hit. PS00862. OX2_COVAL_FAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALO_NEUCR

Accession

Primary (citable) accession number: Q7SGY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	December 15, 2003
Last modified:	November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)