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Protein

Putative D-arabinono-1,4-lactone oxidase

Gene

alo-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathwayi: D-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Putative D-arabinono-1,4-lactone oxidase (alo-1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:alo-1
ORF Names:NCU03188
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:NCU03188

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001281681 – 556Putative D-arabinono-1,4-lactone oxidaseAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84Pros-8alpha-FAD histidineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliQ7SGY1
SMRiQ7SGY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 217FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST171

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000204635
InParanoidiQ7SGY1
KOiK00107
OMAiIAADDIW
OrthoDBiEOG092C14O7

Family and domain databases

Gene3Di3.30.43.10, 1 hit
InterProiView protein in InterPro
IPR007173 ALO
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR010031 FAD_lactone_oxidase
IPR006094 Oxid_FAD_bind_N
IPR006093 Oxy_OxRdtase_FAD_BS
IPR030654 Sugar_lactone_oxidase
PANTHERiPTHR43762 PTHR43762, 1 hit
PfamiView protein in Pfam
PF04030 ALO, 1 hit
PF01565 FAD_binding_4, 1 hit
PIRSFiPIRSF000136 LGO_GLO, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR01678 FAD_lactone_ox, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit
PS00862 OX2_COVAL_FAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q7SGY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATESNPALA SLPSNVREII ELASQRDGGI PFRAKTAHVH RTWAGTFTSL
60 70 80 90 100
PELYIQPESV SEIQKVVRLA RHARRRVTTT GCGHSPSDIT CTSSWLVNLD
110 120 130 140 150
NFNKVISVDH LTGLVVVQAG IRLYQLSDEL DRRGLALPSL GSINEQSIAG
160 170 180 190 200
AISTGTHGSG IKHGLVGESI TELKITLANG ETLSCSPEDK PDLFRAALIS
210 220 230 240 250
LGALGIITEV TFKAVPAFSL AWSQAIDSDK RIFEKWEKDL WSQAEFVRIW
260 270 280 290 300
WFPYMRRAAV WTANVVDPVD LKTGAVKHRE PPTSYYDSWL GYYVYHNLLA
310 320 330 340 350
LSRWIPRITP WIEWFVFGMQ YGFKNGEVTR IGAVQPSQKA FLLNCLYSQS
360 370 380 390 400
VNEWAIPLHK GPEALQRLGA WLQNLKPGDP GYVEHGIPYS AEGLWVHSPV
410 420 430 440 450
EVRASDSTVY TSREANTRPF LDPTQSDGPT LYLNAIMYRP YHREPTYNAT
460 470 480 490 500
ERYYLGFEWL MRELGGKPHW AKTFTATQAD LARWYGDDFQ RWGAVRESVD
510 520 530 540 550
PEGMFVGPWH RRYLLEPLQR DRLLPLEEIQ QTTKKVPARQ GGGIEVIGIQ

NLVAPN
Length:556
Mass (Da):62,600
Last modified:December 15, 2003 - v1
Checksum:i7E8FDCCF866F10ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA Translation: EAA36052.1
RefSeqiXP_965288.1, XM_960195.2

Genome annotation databases

EnsemblFungiiEAA36052; EAA36052; NCU03188
GeneIDi3881437
KEGGincr:NCU03188

Similar proteinsi

Entry informationi

Entry nameiALO_NEUCR
AccessioniPrimary (citable) accession number: Q7SGY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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