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Q7SGY1

- ALO_NEUCR

UniProt

Q7SGY1 - ALO_NEUCR

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Protein

Putative D-arabinono-1,4-lactone oxidase

Gene

alo-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathwayi

GO - Molecular functioni

  1. D-arabinono-1,4-lactone oxidase activity Source: UniProtKB-EC
  2. flavin adenine dinucleotide binding Source: InterPro
  3. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:alo-1
ORF Names:NCU03188
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Mitochondrion membrane By similarity
Note: Membrane-embedded.By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Putative D-arabinono-1,4-lactone oxidasePRO_0000128168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841Pros-8alpha-FAD histidineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU03188.1.

Structurei

3D structure databases

ProteinModelPortaliQ7SGY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 217171FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0277.
HOGENOMiHOG000204635.
InParanoidiQ7SGY1.
KOiK00107.
OMAiMDCLFSQ.
OrthoDBiEOG7JX3CZ.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR023595. LGO_GLO.
IPR006094. Oxid_FAD_bind_N.
IPR006093. Oxy_OxRdtase_FAD_BS.
[Graphical view]
PfamiPF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
PS00862. OX2_COVAL_FAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SGY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATESNPALA SLPSNVREII ELASQRDGGI PFRAKTAHVH RTWAGTFTSL
60 70 80 90 100
PELYIQPESV SEIQKVVRLA RHARRRVTTT GCGHSPSDIT CTSSWLVNLD
110 120 130 140 150
NFNKVISVDH LTGLVVVQAG IRLYQLSDEL DRRGLALPSL GSINEQSIAG
160 170 180 190 200
AISTGTHGSG IKHGLVGESI TELKITLANG ETLSCSPEDK PDLFRAALIS
210 220 230 240 250
LGALGIITEV TFKAVPAFSL AWSQAIDSDK RIFEKWEKDL WSQAEFVRIW
260 270 280 290 300
WFPYMRRAAV WTANVVDPVD LKTGAVKHRE PPTSYYDSWL GYYVYHNLLA
310 320 330 340 350
LSRWIPRITP WIEWFVFGMQ YGFKNGEVTR IGAVQPSQKA FLLNCLYSQS
360 370 380 390 400
VNEWAIPLHK GPEALQRLGA WLQNLKPGDP GYVEHGIPYS AEGLWVHSPV
410 420 430 440 450
EVRASDSTVY TSREANTRPF LDPTQSDGPT LYLNAIMYRP YHREPTYNAT
460 470 480 490 500
ERYYLGFEWL MRELGGKPHW AKTFTATQAD LARWYGDDFQ RWGAVRESVD
510 520 530 540 550
PEGMFVGPWH RRYLLEPLQR DRLLPLEEIQ QTTKKVPARQ GGGIEVIGIQ

NLVAPN
Length:556
Mass (Da):62,600
Last modified:December 15, 2003 - v1
Checksum:i7E8FDCCF866F10ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA36052.1.
RefSeqiXP_965288.1. XM_960195.1.

Genome annotation databases

EnsemblFungiiEFNCRT00000002860; EFNCRP00000002860; EFNCRG00000002857.
GeneIDi3881437.
KEGGincr:NCU03188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA36052.1 .
RefSeqi XP_965288.1. XM_960195.1.

3D structure databases

ProteinModelPortali Q7SGY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU03188.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000002860 ; EFNCRP00000002860 ; EFNCRG00000002857 .
GeneIDi 3881437.
KEGGi ncr:NCU03188.

Phylogenomic databases

eggNOGi COG0277.
HOGENOMi HOG000204635.
InParanoidi Q7SGY1.
KOi K00107.
OMAi MDCLFSQ.
OrthoDBi EOG7JX3CZ.

Enzyme and pathway databases

UniPathwayi UPA00771 ; UER00766 .

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProi IPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR023595. LGO_GLO.
IPR006094. Oxid_FAD_bind_N.
IPR006093. Oxy_OxRdtase_FAD_BS.
[Graphical view ]
Pfami PF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view ]
PIRSFi PIRSF000136. LGO_GLO. 1 hit.
SUPFAMi SSF56176. SSF56176. 1 hit.
TIGRFAMsi TIGR01678. FAD_lactone_ox. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
PS00862. OX2_COVAL_FAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiALO_NEUCR
AccessioniPrimary (citable) accession number: Q7SGY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3