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Q7SGY1

- ALO_NEUCR

UniProt

Q7SGY1 - ALO_NEUCR

Protein

Putative D-arabinono-1,4-lactone oxidase

Gene

alo-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

    Cofactori

    FAD.By similarity

    Pathwayi

    GO - Molecular functioni

    1. D-arabinono-1,4-lactone oxidase activity Source: UniProtKB-EC
    2. flavin adenine dinucleotide binding Source: InterPro
    3. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00771; UER00766.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
    Short name:
    ALO
    Alternative name(s):
    L-galactono-gamma-lactone oxidase
    Gene namesi
    Name:alo-1
    ORF Names:NCU03188
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    Mitochondrion membrane By similarity
    Note: Membrane-embedded.By similarity

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Putative D-arabinono-1,4-lactone oxidasePRO_0000128168Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei84 – 841Pros-8alpha-FAD histidineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU03188.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7SGY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 217171FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0277.
    HOGENOMiHOG000204635.
    KOiK00107.
    OMAiMDCLFSQ.
    OrthoDBiEOG7JX3CZ.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProiIPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    IPR006093. Oxy_OxRdtase_FAD_BS.
    [Graphical view]
    PfamiPF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000136. LGO_GLO. 1 hit.
    SUPFAMiSSF56176. SSF56176. 1 hit.
    TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    PS00862. OX2_COVAL_FAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SGY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATESNPALA SLPSNVREII ELASQRDGGI PFRAKTAHVH RTWAGTFTSL    50
    PELYIQPESV SEIQKVVRLA RHARRRVTTT GCGHSPSDIT CTSSWLVNLD 100
    NFNKVISVDH LTGLVVVQAG IRLYQLSDEL DRRGLALPSL GSINEQSIAG 150
    AISTGTHGSG IKHGLVGESI TELKITLANG ETLSCSPEDK PDLFRAALIS 200
    LGALGIITEV TFKAVPAFSL AWSQAIDSDK RIFEKWEKDL WSQAEFVRIW 250
    WFPYMRRAAV WTANVVDPVD LKTGAVKHRE PPTSYYDSWL GYYVYHNLLA 300
    LSRWIPRITP WIEWFVFGMQ YGFKNGEVTR IGAVQPSQKA FLLNCLYSQS 350
    VNEWAIPLHK GPEALQRLGA WLQNLKPGDP GYVEHGIPYS AEGLWVHSPV 400
    EVRASDSTVY TSREANTRPF LDPTQSDGPT LYLNAIMYRP YHREPTYNAT 450
    ERYYLGFEWL MRELGGKPHW AKTFTATQAD LARWYGDDFQ RWGAVRESVD 500
    PEGMFVGPWH RRYLLEPLQR DRLLPLEEIQ QTTKKVPARQ GGGIEVIGIQ 550
    NLVAPN 556
    Length:556
    Mass (Da):62,600
    Last modified:December 15, 2003 - v1
    Checksum:i7E8FDCCF866F10ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36052.1.
    RefSeqiXP_965288.1. XM_960195.1.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000002860; EFNCRP00000002860; EFNCRG00000002857.
    GeneIDi3881437.
    KEGGincr:NCU03188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA36052.1 .
    RefSeqi XP_965288.1. XM_960195.1.

    3D structure databases

    ProteinModelPortali Q7SGY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU03188.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000002860 ; EFNCRP00000002860 ; EFNCRG00000002857 .
    GeneIDi 3881437.
    KEGGi ncr:NCU03188.

    Phylogenomic databases

    eggNOGi COG0277.
    HOGENOMi HOG000204635.
    KOi K00107.
    OMAi MDCLFSQ.
    OrthoDBi EOG7JX3CZ.

    Enzyme and pathway databases

    UniPathwayi UPA00771 ; UER00766 .

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProi IPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    IPR006093. Oxy_OxRdtase_FAD_BS.
    [Graphical view ]
    Pfami PF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000136. LGO_GLO. 1 hit.
    SUPFAMi SSF56176. SSF56176. 1 hit.
    TIGRFAMsi TIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    PS00862. OX2_COVAL_FAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiALO_NEUCR
    AccessioniPrimary (citable) accession number: Q7SGY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3