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Protein

NADH-cytochrome b5 reductase 2

Gene

mcr-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May mediate the reduction of outer membrane cytochrome b5.By similarity

Catalytic activityi

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 235FADBy similarityAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-cytochrome b5 reductase 2 (EC:1.6.2.2)
Alternative name(s):
Mitochondrial cytochrome b reductase
Gene namesi
Name:mcr-1
ORF Names:NCU03112
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU03112.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003301861 – 343NADH-cytochrome b5 reductase 2Add BLAST343

Structurei

3D structure databases

ProteinModelPortaliQ7SFY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 197FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000175005.
InParanoidiQ7SFY2.
KOiK00326.
OMAiKHDHIAL.
OrthoDBiEOG092C43G8.

Family and domain databases

InterProiIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00406. CYTB5RDTASE.
PR00371. FPNCR.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SFY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFVASTRS AFRAAAPIKR SFQTRRSYAT EPSKGGSSST ILLGAAAVGL
60 70 80 90 100
AGAGAYFFSG AGAAKKAEAS VKQVTEKITP GEIKKAFVGG DQGWLSLKLE
110 120 130 140 150
EVELVNHNTK RLRFRLPEDD MVSGLHVASA ILTKFKPIDA EKAVLRPYTP
160 170 180 190 200
ISDESAQGYI DLLVKKYEGG PMSTYLHDMA PGQRLDIKGP LPKYPWEANK
210 220 230 240 250
HKHIALVAGG TGITPMYQLI RAIFNNPDDK TKVTLVFGNV SEEDVLLKHE
260 270 280 290 300
LATIENHYPQ RFRAFYVLDN PPKEWAGNKG YINKDLLKTV LPEPKNEDIK
310 320 330 340
IFVCGPPGMM NSISGNKKSP RDQGELTGIL KELGYSPDQV YKF
Length:343
Mass (Da):37,641
Last modified:December 15, 2003 - v1
Checksum:iD68BBEA1281FA660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35735.1.
RefSeqiXP_964971.1. XM_959878.2.

Genome annotation databases

EnsemblFungiiEAA35735; EAA35735; NCU03112.
GeneIDi3881129.
KEGGincr:NCU03112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35735.1.
RefSeqiXP_964971.1. XM_959878.2.

3D structure databases

ProteinModelPortaliQ7SFY2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA35735; EAA35735; NCU03112.
GeneIDi3881129.
KEGGincr:NCU03112.

Organism-specific databases

EuPathDBiFungiDB:NCU03112.

Phylogenomic databases

HOGENOMiHOG000175005.
InParanoidiQ7SFY2.
KOiK00326.
OMAiKHDHIAL.
OrthoDBiEOG092C43G8.

Family and domain databases

InterProiIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00406. CYTB5RDTASE.
PR00371. FPNCR.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCR1_NEUCR
AccessioniPrimary (citable) accession number: Q7SFY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.