Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7SFY0

- SSU72_NEUCR

UniProt

Q7SFY0 - SSU72_NEUCR

Protein

RNA polymerase II subunit A C-terminal domain phosphatase ssu-72

Gene

ssu-72

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb-1).By similarity
    Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu-72 is required for 3'-end formation of snoRNAs By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase ssu-72 (EC:3.1.3.16)
    Short name:
    CTD phosphatase ssu-72
    Alternative name(s):
    Suppressor of SUA7 protein 2 homolog
    Gene namesi
    Name:ssu-72
    ORF Names:NCU03114
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266RNA polymerase II subunit A C-terminal domain phosphatase ssu-72PRO_0000255611Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

    Protein-protein interaction databases

    STRINGi5141.NCU03114.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7SFY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SSU72 phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG5211.
    HOGENOMiHOG000183445.
    KOiK15544.
    OMAiWQERWPN.
    OrthoDBiEOG7GTTG0.

    Family and domain databases

    InterProiIPR006811. RNA_pol_II_suA.
    [Graphical view]
    PANTHERiPTHR20383. PTHR20383. 1 hit.
    PfamiPF04722. Ssu72. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SFY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAVDTPTGA ASSSKPDQNE QNGQNGGRED SGGFKLKFCT VCASNQNRSM    50
    EGHLRLSLAN YPVISFGTGS LVRLPGPSIT QPNVYKFNET SYDSIYRELE 100
    AKDPRLYRAN GLLNMLGRNR QVKWGPERWQ DWQIGMPRTK HKDDKGADGM 150
    EGGVADVVIT CEERCWDAVI EDLLNRGSPL NRPVHVINID IKDNHEEASV 200
    GGRAIVDLAD SLNKIAAEER EKVGASAFDS GSVGARSGFD ERVPDVLAEW 250
    QERWPNLPAT WTLAWF 266
    Length:266
    Mass (Da):29,420
    Last modified:December 15, 2003 - v1
    Checksum:i32757F39A363401F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA35737.1.
    RefSeqiXP_964973.1. XM_959880.1.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000002984; EFNCRP00000002984; EFNCRG00000002981.
    GeneIDi3881131.
    KEGGincr:NCU03114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA35737.1 .
    RefSeqi XP_964973.1. XM_959880.1.

    3D structure databases

    ProteinModelPortali Q7SFY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU03114.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000002984 ; EFNCRP00000002984 ; EFNCRG00000002981 .
    GeneIDi 3881131.
    KEGGi ncr:NCU03114.

    Phylogenomic databases

    eggNOGi COG5211.
    HOGENOMi HOG000183445.
    KOi K15544.
    OMAi WQERWPN.
    OrthoDBi EOG7GTTG0.

    Family and domain databases

    InterProi IPR006811. RNA_pol_II_suA.
    [Graphical view ]
    PANTHERi PTHR20383. PTHR20383. 1 hit.
    Pfami PF04722. Ssu72. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiSSU72_NEUCR
    AccessioniPrimary (citable) accession number: Q7SFY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3