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Q7SFY0 (SSU72_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase ssu-72

Short name=CTD phosphatase ssu-72
EC=3.1.3.16
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene names
Name:ssu-72
ORF Names:NCU03114
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb-1) By similarity.

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu-72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdephosphorylation

Inferred from electronic annotation. Source: GOC

mRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266RNA polymerase II subunit A C-terminal domain phosphatase ssu-72
PRO_0000255611

Sequences

Sequence LengthMass (Da)Tools
Q7SFY0 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 32757F39A363401F

FASTA26629,420
        10         20         30         40         50         60 
MSAVDTPTGA ASSSKPDQNE QNGQNGGRED SGGFKLKFCT VCASNQNRSM EGHLRLSLAN 

        70         80         90        100        110        120 
YPVISFGTGS LVRLPGPSIT QPNVYKFNET SYDSIYRELE AKDPRLYRAN GLLNMLGRNR 

       130        140        150        160        170        180 
QVKWGPERWQ DWQIGMPRTK HKDDKGADGM EGGVADVVIT CEERCWDAVI EDLLNRGSPL 

       190        200        210        220        230        240 
NRPVHVINID IKDNHEEASV GGRAIVDLAD SLNKIAAEER EKVGASAFDS GSVGARSGFD 

       250        260 
ERVPDVLAEW QERWPNLPAT WTLAWF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002236 Genomic DNA. Translation: EAA35737.1.
RefSeqXP_964973.1. XM_959880.1.

3D structure databases

ProteinModelPortalQ7SFY0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU03114.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000002984; EFNCRP00000002984; EFNCRG00000002981.
GeneID3881131.
KEGGncr:NCU03114.

Phylogenomic databases

eggNOGCOG5211.
HOGENOMHOG000183445.
KOK15544.
OMAWQERWPN.
OrthoDBEOG7GTTG0.

Family and domain databases

InterProIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSU72_NEUCR
AccessionPrimary (citable) accession number: Q7SFY0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families