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Protein

RNA polymerase II subunit A C-terminal domain phosphatase ssu-72

Gene

ssu-72

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb-1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu-72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. CTD phosphatase activity Source: EnsemblFungi
  2. protein tyrosine phosphatase activity Source: EnsemblFungi

GO - Biological processi

  1. dephosphorylation of RNA polymerase II C-terminal domain Source: EnsemblFungi
  2. mRNA 3'-end processing Source: EnsemblFungi
  3. mRNA cleavage Source: EnsemblFungi
  4. snoRNA transcription Source: EnsemblFungi
  5. termination of RNA polymerase II transcription, exosome-dependent Source: EnsemblFungi
  6. termination of RNA polymerase II transcription, poly(A)-coupled Source: EnsemblFungi
  7. transcriptional start site selection at RNA polymerase II promoter Source: EnsemblFungi
  8. transcription antitermination Source: EnsemblFungi
  9. transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase ssu-72 (EC:3.1.3.16)
Short name:
CTD phosphatase ssu-72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:ssu-72
ORF Names:NCU03114
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU03114.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
  2. mRNA cleavage and polyadenylation specificity factor complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266RNA polymerase II subunit A C-terminal domain phosphatase ssu-72PRO_0000255611Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Protein-protein interaction databases

STRINGi5141.NCU03114.1.

Structurei

3D structure databases

ProteinModelPortaliQ7SFY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ7SFY0.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SFY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVDTPTGA ASSSKPDQNE QNGQNGGRED SGGFKLKFCT VCASNQNRSM
60 70 80 90 100
EGHLRLSLAN YPVISFGTGS LVRLPGPSIT QPNVYKFNET SYDSIYRELE
110 120 130 140 150
AKDPRLYRAN GLLNMLGRNR QVKWGPERWQ DWQIGMPRTK HKDDKGADGM
160 170 180 190 200
EGGVADVVIT CEERCWDAVI EDLLNRGSPL NRPVHVINID IKDNHEEASV
210 220 230 240 250
GGRAIVDLAD SLNKIAAEER EKVGASAFDS GSVGARSGFD ERVPDVLAEW
260
QERWPNLPAT WTLAWF
Length:266
Mass (Da):29,420
Last modified:December 15, 2003 - v1
Checksum:i32757F39A363401F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35737.1.
RefSeqiXP_964973.1. XM_959880.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000002984; EFNCRP00000002984; EFNCRG00000002981.
GeneIDi3881131.
KEGGincr:NCU03114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35737.1.
RefSeqiXP_964973.1. XM_959880.2.

3D structure databases

ProteinModelPortaliQ7SFY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5141.NCU03114.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000002984; EFNCRP00000002984; EFNCRG00000002981.
GeneIDi3881131.
KEGGincr:NCU03114.

Organism-specific databases

EuPathDBiFungiDB:NCU03114.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ7SFY0.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiSSU72_NEUCR
AccessioniPrimary (citable) accession number: Q7SFY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 15, 2003
Last modified: April 29, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.