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Q7SFX7

- IMDH_NEUCR

UniProt

Q7SFX7 - IMDH_NEUCR

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
NCU03117
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi335 – 3351Potassium; via carbonyl oxygen By similarity
Metal bindingi337 – 3371Potassium; via carbonyl oxygen By similarity
Binding sitei338 – 3381IMP By similarity
Active sitei340 – 3401Thioimidate intermediate By similarity
Metal bindingi340 – 3401Potassium; via carbonyl oxygen By similarity
Binding sitei463 – 4631IMP By similarity
Metal bindingi522 – 5221Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi523 – 5231Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi524 – 5241Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi283 – 2853NAD By similarity
Nucleotide bindingi333 – 3353NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
ORF Names:NCU03117
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000415687Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi5141.NCU03117.1.

Structurei

3D structure databases

ProteinModelPortaliQ7SFX7.
SMRiQ7SFX7. Positions 22-407.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 18762CBS 1
Add
BLAST
Domaini189 – 24557CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni373 – 3753IMP binding By similarity
Regioni396 – 3972IMP binding By similarity
Regioni421 – 4255IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
HOGENOMiHOG000165752.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG793BHK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SFX7-1 [UniParc]FASTAAdd to Basket

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MAVNGNNTFL DHTSAMEVLK EYERRDGLDI RDLMDSKLQG GLTYNDFLLL    50
PGYIGFPASA VTLDSPITKR ITLKTPLVSS PMDTVTEHEM AIHMALQGGV 100
GVIHHNCSPD EQADMVRKVK RYENGFILDP VVITRDTTVG EAKALKEKWG 150
FGGFPVTESG NLGSKLVGIV TNRDIQFETD LDKPVSEVMV TDLITATAGV 200
NLLEANKILA ESKKGKLPII DKEGNLVSMI SRSDLTKNLH FPLASKTKDS 250
KQLICAAAIG TRPEDKDRLA KLVDAGLDIV ILDSSQGNSM YQIEMIKWIK 300
KEFPDLDVIG GNVVTREQAA ALIAAGVDGL RIGMGSGSAC ITQEVMAVGR 350
PQATAVYNVS SFAARFGVPC IADGGIQNVG HIVKGLALGA STVMMGGLLA 400
GTTESPGTSF VSREGKLVKA YRGMGSIDAM QDKKAGGGGK DAQKSNAGTA 450
RYFSEGDSIL VAQGVSGAVA HRGSINKFVP YLAAGLKHSL QDCGMTSLQE 500
LHECVENGTV RFEIRTASAQ LEGGVNMESY EKKLYA 536
Length:536
Mass (Da):57,159
Last modified:December 15, 2003 - v1
Checksum:iA18ED8F90E4748AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA35740.1.
RefSeqiXP_964976.1. XM_959883.2.
UniGeneiNcr.24401.

Genome annotation databases

EnsemblFungiiEFNCRT00000003006; EFNCRP00000003006; EFNCRG00000003003.
GeneIDi3881134.
KEGGincr:NCU03117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA35740.1 .
RefSeqi XP_964976.1. XM_959883.2.
UniGenei Ncr.24401.

3D structure databases

ProteinModelPortali Q7SFX7.
SMRi Q7SFX7. Positions 22-407.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5141.NCU03117.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000003006 ; EFNCRP00000003006 ; EFNCRG00000003003 .
GeneIDi 3881134.
KEGGi ncr:NCU03117.

Phylogenomic databases

eggNOGi COG0517.
HOGENOMi HOG000165752.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG793BHK.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiIMDH_NEUCR
AccessioniPrimary (citable) accession number: Q7SFX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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