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Protein

Pescadillo homolog

Gene

nop7

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pescadillo homologUniRule annotation
Alternative name(s):
Nucleolar protein 7 homologUniRule annotation
Gene namesi
Name:nop7
ORF Names:G17B7.070, NCU00925
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU00925.

Subcellular locationi

  • Nucleusnucleolus UniRule annotation
  • Nucleusnucleoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003704981 – 663Pescadillo homologAdd BLAST663

Proteomic databases

PRIDEiQ7SFC2.

Interactioni

Subunit structurei

Component of the NOP7 complex, composed of erb1, nop7 and ytm1. The complex is held together by erb1, which interacts with nop7 via its N-terminal domain and with ytm1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7SFC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini361 – 477BRCTUniRule annotationAdd BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili501 – 663UniRule annotationAdd BLAST163

Sequence similaritiesi

Belongs to the pescadillo family.UniRule annotation
Contains 1 BRCT domain.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000006022.
InParanoidiQ7SFC2.
KOiK14843.
OrthoDBiEOG092C1M1S.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di3.40.50.10190. 1 hit.
HAMAPiMF_03028. Pescadillo. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR010613. PES.
[Graphical view]
PfamiPF06732. Pescadillo_N. 1 hit.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SFC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKIKKKGQA GAAKNYITRT QAVKKLQLSL PDFRKLCIWK GIYPREPRNK
60 70 80 90 100
KKVSKSATAS TTFYYTKDIQ YLLHEPLLQK FRDQKVLEKK ISRALGRGDV
110 120 130 140 150
SDAARFERHA ARPEATGKPR YTLNHVIRER YPTFNDALRD LDDCLSMLFL
160 170 180 190 200
FANLPSTSAV PAKMIARCER LCLEFQHYLI VSHSLRKSFL SIKGIYYQAN
210 220 230 240 250
IQGEDILWLV PYKFNQRIVG DVDFRIMGTF VEFYMTLLGF VNYRLYSSIG
260 270 280 290 300
LKYPPKFDQL KDENGAELGA FSLEGVNMAT QGETKAVTNG EEQQQGPDPK
310 320 330 340 350
VQAEVDKIIK QLKEDESKSD ETAEEDAEAD DEEKPTDSID KFEPVAPGGD
360 370 380 390 400
VLPQPAYSSS DPSQLFANFT FYLSRETPRQ PLEFILRAFG CKRIGWDSVL
410 420 430 440 450
GEGAFTNDES DPSITHHIID RPVVQAATNE DGDGEDNQTA QKVGPNQRYP
460 470 480 490 500
GRIYVQPQWV WDCVNDEELK SPELYAPGAA LPPHLSPFVK AAPGQYDPTL
510 520 530 540 550
PLEAQQTEAE AIEADLEDAE KGNAEDGSDV ENDMDVDEAE DDEEEEEGDE
560 570 580 590 600
EDAEEAEEED AEEDEEESKT LQRQLELEAE LQGKKVQNTK VDSKTKAKLE
610 620 630 640 650
QRKALEKKAR EEAEDLERAK GMLSKKKRKL FEQMQYTNNK KSAQDEKLRA
660
KRRKLEKEKA QKA
Length:663
Mass (Da):75,293
Last modified:December 15, 2003 - v1
Checksum:iC33A1DB1C8E18114
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842638 Genomic DNA. Translation: CAE76578.1.
CM002236 Genomic DNA. Translation: EAA35515.1.
RefSeqiXP_964751.1. XM_959658.2.

Genome annotation databases

EnsemblFungiiEAA35515; EAA35515; NCU00925.
GeneIDi3880904.
KEGGincr:NCU00925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842638 Genomic DNA. Translation: CAE76578.1.
CM002236 Genomic DNA. Translation: EAA35515.1.
RefSeqiXP_964751.1. XM_959658.2.

3D structure databases

ProteinModelPortaliQ7SFC2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7SFC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA35515; EAA35515; NCU00925.
GeneIDi3880904.
KEGGincr:NCU00925.

Organism-specific databases

EuPathDBiFungiDB:NCU00925.

Phylogenomic databases

HOGENOMiHOG000006022.
InParanoidiQ7SFC2.
KOiK14843.
OrthoDBiEOG092C1M1S.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di3.40.50.10190. 1 hit.
HAMAPiMF_03028. Pescadillo. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR010613. PES.
[Graphical view]
PfamiPF06732. Pescadillo_N. 1 hit.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPESC_NEUCR
AccessioniPrimary (citable) accession number: Q7SFC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: December 15, 2003
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.