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Protein

Hexokinase

Gene

NCU00575

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
ORF Names:NCU00575Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU00575.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ7SF75.
KOiK00844.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SF75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRIREVPL PLPMQADDAS SASFTGGAVL DMPGVTRRRR SVNSSTAPDP
60 70 80 90 100
AAAHKAGVQA RGSADDSRYH HGLSRLESSL DYSTEAGNPN ISKSRSEEKE
110 120 130 140 150
ARKRQTDAGA DIPSSPGSPP SPRAAVFTRF RSTGPSAVSK SQAKREWSQS
160 170 180 190 200
CRGVLTSLIR VLSSSVVFLA VVFVLRALLP DSALHYSSFL SRQSTLTPLT
210 220 230 240 250
TKATFSPPAL SQQAHQPQPP AVCEIHPPFP TPAPVSSPLT MALETQTKTV
260 270 280 290 300
VGQFDYSDED VNKGVVEFLR QMAEGLEKDG ASMSQIPTYV TAVPNGTEKG
310 320 330 340 350
LYMAVDLGGT NFRVCSIQLN GDTTFRLTYT KVAIPRELMV AKTAEELFAF
360 370 380 390 400
LAKQVEIFLR THHGEHFEAH IRRRMTMSSP EGFKDENVFR LGFTFSFPVQ
410 420 430 440 450
QLGINKGTLI RWTKGFDIPD AVGKDVCALL QTEIDKLHLP VKVAALVNDT
460 470 480 490 500
VGTLMARSYS SPGKSGAILG AIFGTGTNGA YVEKLSNIKK PLAGEYDKST
510 520 530 540 550
GEMVINTEWG SFDNQLKVLP NTPWDVQLDL ATPNPGIQMY EKRVSGMYLG
560 570 580 590 600
EILRLTVIDL LKNPDVALFK DDNSSYNDWK STTNIAEHSP IYKQWGLDTS
610 620 630 640 650
VLSVAAADST PELSILRQEL EANLHIYAPS LEDAQAFKAI AGAIGRRAAR
660 670 680 690 700
LSAVAIAAIV LQTGKLNDPE QDEPIDIGVD GSLVEHYPYF RDMIYEALRV
710 720 730 740 750
IKGIGEEGAK RIRIGIAKDG SGVGAALIAL VAARMEKSTS TADFISDLRL
760 770
NAKKTDLTAV PEDSELAAGE
Length:770
Mass (Da):83,383
Last modified:January 22, 2014 - v2
Checksum:i4B24F7799D81A421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35500.2.
RefSeqiXP_964736.1. XM_959643.2.
UniGeneiNcr.15028.

Genome annotation databases

EnsemblFungiiEFNCRT00000000914; EFNCRP00000000914; EFNCRG00000000913.
GeneIDi3880885.
KEGGincr:NCU00575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35500.2.
RefSeqiXP_964736.1. XM_959643.2.
UniGeneiNcr.15028.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5141.NCU00575.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000000914; EFNCRP00000000914; EFNCRG00000000913.
GeneIDi3880885.
KEGGincr:NCU00575.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ7SF75.
KOiK00844.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

Entry informationi

Entry nameiQ7SF75_NEUCR
AccessioniPrimary (citable) accession number: Q7SF75
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 22, 2014
Last modified: March 4, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.