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Q7SEL7

- Q7SEL7_NEUCR

UniProt

Q7SEL7 - Q7SEL7_NEUCR

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Protein
Histone deacetylase
Gene
hda-2, NCU02795
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotations

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:hda-2Imported
ORF Names:NCU02795Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU02795.1.

Structurei

3D structure databases

ProteinModelPortaliQ7SEL7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
KOiK11483.
OMAiNLGGSDC.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q7SEL7-1 [UniParc]FASTAAdd to Basket

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MDTLQSLQWR PPKPNYLPHD IDVDEPIVDV YKPPIPMDKA SDRENQEYYA    50
HMKRMAHEYN ITRPKGYTVS YHFNPDMEPH HFGLTHPMKP FRLTLTKSLV 100
TAYGMNFAMD NYNTRIATYE ELNSFHTSDY LDYLHMAPPE EMPRDIDNPD 150
KEVKFNLGGS DCPLFHGLYD YCSMSAGSSL DAARKICNKQ SDIAIAWGGG 200
LHHAKKSEAS GFCYINDIVI AILQLLRCYP RVLYIDIDVH HGDGVEEAFH 250
STDRVLTCSF HKFAPEVFFP GTGGLDDNGP KSEHNPGAHH AINVPLNDGI 300
TDEQYGHLFQ SVIGKINEKF RPSVIALQCG ADSLAGDRLG RFNLQVQGHG 350
ACAKFCKTFG IPMIMFGGGG YTPRNVARAW AYETSVAIDV DEKINKIIPD 400
HTPWRKHFVQ EELFPSLEQI LGEPRANRNS QKRLQEIIQH VHEQLRFVNA 450
APSVQQQVIP PDLGGIRDDV EDRLKEESEE RDEGLRRDRE EGLGISGEF 499
Length:499
Mass (Da):56,520
Last modified:October 23, 2007 - v2
Checksum:i04DFAEB831E34263
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA35215.2.
RefSeqiXP_964451.2. XM_959358.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000002256; EFNCRP00000002256; EFNCRG00000002253.
GeneIDi3880615.
KEGGincr:NCU02795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002236 Genomic DNA. Translation: EAA35215.2 .
RefSeqi XP_964451.2. XM_959358.2.

3D structure databases

ProteinModelPortali Q7SEL7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5141.NCU02795.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000002256 ; EFNCRP00000002256 ; EFNCRG00000002253 .
GeneIDi 3880615.
KEGGi ncr:NCU02795.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000225180.
KOi K11483.
OMAi NLGGSDC.
OrthoDBi EOG78M0B2.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiQ7SEL7_NEUCR
AccessioniPrimary (citable) accession number: Q7SEL7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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