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Protein

Histone deacetylase

Gene

hda-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161SubstrateUniRule annotation1
Active sitei203Proton acceptorUniRule annotation1
Binding sitei211Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi238Divalent metal cationUniRule annotation1
Metal bindingi240Divalent metal cationUniRule annotation1
Metal bindingi332Divalent metal cationUniRule annotation1
Binding sitei371SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Enzyme and pathway databases

BRENDAi3.5.1.98. 3627.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:hda-2Imported
ORF Names:NCU02795Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU02795.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ7SEL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 385Hist_deacetylInterPro annotationAdd BLAST300

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiQ7SEL7.
KOiK11483.
OMAiPRAWTHL.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q7SEL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLQSLQWR PPKPNYLPHD IDVDEPIVDV YKPPIPMDKA SDRENQEYYA
60 70 80 90 100
HMKRMAHEYN ITRPKGYTVS YHFNPDMEPH HFGLTHPMKP FRLTLTKSLV
110 120 130 140 150
TAYGMNFAMD NYNTRIATYE ELNSFHTSDY LDYLHMAPPE EMPRDIDNPD
160 170 180 190 200
KEVKFNLGGS DCPLFHGLYD YCSMSAGSSL DAARKICNKQ SDIAIAWGGG
210 220 230 240 250
LHHAKKSEAS GFCYINDIVI AILQLLRCYP RVLYIDIDVH HGDGVEEAFH
260 270 280 290 300
STDRVLTCSF HKFAPEVFFP GTGGLDDNGP KSEHNPGAHH AINVPLNDGI
310 320 330 340 350
TDEQYGHLFQ SVIGKINEKF RPSVIALQCG ADSLAGDRLG RFNLQVQGHG
360 370 380 390 400
ACAKFCKTFG IPMIMFGGGG YTPRNVARAW AYETSVAIDV DEKINKIIPD
410 420 430 440 450
HTPWRKHFVQ EELFPSLEQI LGEPRANRNS QKRLQEIIQH VHEQLRFVNA
460 470 480 490
APSVQQQVIP PDLGGIRDDV EDRLKEESEE RDEGLRRDRE EGLGISGEF
Length:499
Mass (Da):56,520
Last modified:October 23, 2007 - v2
Checksum:i04DFAEB831E34263
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35215.2.
RefSeqiXP_964451.2. XM_959358.2.

Genome annotation databases

EnsemblFungiiEAA35215; EAA35215; NCU02795.
GeneIDi3880615.
KEGGincr:NCU02795.

Similar proteinsi

Entry informationi

Entry nameiQ7SEL7_NEUCR
AccessioniPrimary (citable) accession number: Q7SEL7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: August 30, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported