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Protein

Histone deacetylase

Gene

hda-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Enzyme and pathway databases

BRENDAi3.5.1.98. 3627.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:hda-2Imported
ORF Names:NCU02795Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU02795.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7SEL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 385300Hist_deacetylInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiQ7SEL7.
KOiK11483.
OMAiHHGFRGR.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q7SEL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLQSLQWR PPKPNYLPHD IDVDEPIVDV YKPPIPMDKA SDRENQEYYA
60 70 80 90 100
HMKRMAHEYN ITRPKGYTVS YHFNPDMEPH HFGLTHPMKP FRLTLTKSLV
110 120 130 140 150
TAYGMNFAMD NYNTRIATYE ELNSFHTSDY LDYLHMAPPE EMPRDIDNPD
160 170 180 190 200
KEVKFNLGGS DCPLFHGLYD YCSMSAGSSL DAARKICNKQ SDIAIAWGGG
210 220 230 240 250
LHHAKKSEAS GFCYINDIVI AILQLLRCYP RVLYIDIDVH HGDGVEEAFH
260 270 280 290 300
STDRVLTCSF HKFAPEVFFP GTGGLDDNGP KSEHNPGAHH AINVPLNDGI
310 320 330 340 350
TDEQYGHLFQ SVIGKINEKF RPSVIALQCG ADSLAGDRLG RFNLQVQGHG
360 370 380 390 400
ACAKFCKTFG IPMIMFGGGG YTPRNVARAW AYETSVAIDV DEKINKIIPD
410 420 430 440 450
HTPWRKHFVQ EELFPSLEQI LGEPRANRNS QKRLQEIIQH VHEQLRFVNA
460 470 480 490
APSVQQQVIP PDLGGIRDDV EDRLKEESEE RDEGLRRDRE EGLGISGEF
Length:499
Mass (Da):56,520
Last modified:October 23, 2007 - v2
Checksum:i04DFAEB831E34263
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35215.2.
RefSeqiXP_964451.2. XM_959358.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000002256; EFNCRP00000002256; EFNCRG00000002253.
GeneIDi3880615.
KEGGincr:NCU02795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA35215.2.
RefSeqiXP_964451.2. XM_959358.2.

3D structure databases

ProteinModelPortaliQ7SEL7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000002256; EFNCRP00000002256; EFNCRG00000002253.
GeneIDi3880615.
KEGGincr:NCU02795.

Organism-specific databases

EuPathDBiFungiDB:NCU02795.

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiQ7SEL7.
KOiK11483.
OMAiHHGFRGR.
OrthoDBiEOG092C1END.

Enzyme and pathway databases

BRENDAi3.5.1.98. 3627.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Entry informationi

Entry nameiQ7SEL7_NEUCR
AccessioniPrimary (citable) accession number: Q7SEL7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.