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Q7SDX3 (3HAO_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Biosynthesis of nicotinic acid protein 1
Gene names
Name:bna1
ORF Names:NCU03282
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1801803-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361991

Sites

Metal binding481Iron; catalytic By similarity
Metal binding541Iron; catalytic By similarity
Metal binding921Iron; catalytic By similarity
Metal binding1211Divalent metal cation By similarity
Metal binding1241Divalent metal cation By similarity
Metal binding1581Divalent metal cation By similarity
Metal binding1611Divalent metal cation By similarity
Binding site441Dioxygen By similarity
Binding site541Substrate By similarity
Binding site961Substrate By similarity
Binding site1061Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7SDX3 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 932C6A2C709B50DE

FASTA18020,557
        10         20         30         40         50         60 
MLSSPVNLPK WLEENSHLLK PPINNYCVYN DDFTVMIVGG PNARTDYHIN QTPEWFYQYK 

        70         80         90        100        110        120 
GAMMLKVVDD GNFRDIIIRE GEMFLLPGNT PHNPVRFADT VGIVLEQKRP ADTIDRMRWY 

       130        140        150        160        170        180 
CQNCKEIVHE ASFHCTDLGT QIKAAVEAFK GNEQLRTCKK CGVLADWSPK PGSIQDPNVQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002236 Genomic DNA. Translation: EAA34972.1.
RefSeqXP_964208.1. XM_959115.2.
UniGeneNcr.16068.

3D structure databases

ProteinModelPortalQ7SDX3.
SMRQ7SDX3. Positions 3-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU03282.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000002760; EFNCRP00000002760; EFNCRG00000002757.
GeneID3880357.
KEGGncr:NCU03282.

Phylogenomic databases

eggNOGNOG77058.
HOGENOMHOG000218448.
KOK00452.
OMAHINQTPE.
OrthoDBEOG7QK0Q0.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_NEUCR
AccessionPrimary (citable) accession number: Q7SDX3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways