Q7SDV9 (CCPR_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c peroxidase, mitochondrial
Short name=CCP
EC=1.11.1.5

Gene names

Name:	ccp-1
ORF Names:	NCU03297

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Subunit structure	Forms a one-to-one complex with cytochrome c By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytochrome-c peroxidase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 38	38	Mitochondrion Potential
	Chain	39 – 358	320	Cytochrome c peroxidase, mitochondrial		PRO_0000045295
Sites
	Active site	119	1	Proton acceptor By similarity
	Active site	258	1	Tryptophan radical intermediate By similarity
	Metal binding	242	1	Iron (heme axial ligand)
	Site	115	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SDV9 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 8F9E48B7328CD87B	FASTA	358	39,818
	10 20 30 40 50 60 MAASRTATRT LRALRTSTRP ALTAAPRAAF RQGGRRLYSS EPAKSGGSNI WAWAIGAGAL 70 80 90 100 110 120 GAGGLWYLNQ DGASATPKVF APKFDDYQAV YNEIASRLEE KDDYDDGSYG PVLVRLAWHA 130 140 150 160 170 180 SGTYDKETGT GGSNGATMRF APESDHGANA GLKAARDFLE PVKAKFPWIT YSDLWILGGV 190 200 210 220 230 240 CAIQEMLGPQ IPYRPGRQDR DAAGCTPDGR LPDASQAQDH LRNIFYRMGF NDQEIVALSG 250 260 270 280 290 300 AHALGRCHAD RSGFDGPWTF SPTVLTNDYY KLLLDEKWQW KKWNGPKQYE DKKTKSLMML 310 320 330 340 350 PADMALIQDK KFKQWVEKYA ADNELFFKDF SNVIVKLFEL GVPFAENSER WVFKTVNA

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000009 Genomic DNA. Translation: EAA34987.1.
RefSeq	XP_964223.1. XM_959130.2.
UniGene	Ncr.24554.
3D structure databases
ProteinModelPortal	Q7SDV9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7SDV9.
Protein family/group databases
PeroxiBase	1989. NcCcP.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000002864; EFNCRP00000002864; EFNCRG00000002861.
GeneID	3880372.
KEGG	ncr:NCU03297.
NMPDR	fig|5141.1.peg.8666.
Phylogenomic databases
eggNOG	fuNOG05104.
GeneTree	EFGT00050000003307.
OMA	DHGANAG.
OrthoDB	EOG49GPRM.
Family and domain databases
InterPro	IPR002207. Asc_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
KO	K00428.
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR_NEUCR

Accession

Primary (citable) accession number: Q7SDV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 15, 2003
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program