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Q7SDD5

- PMIP_NEUCR

UniProt

Q7SDD5 - PMIP_NEUCR

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Protein

Mitochondrial intermediate peptidase

Gene

oct-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi578 – 5781Zinc; catalyticPROSITE-ProRule annotation
Active sitei579 – 5791PROSITE-ProRule annotation
Metal bindingi582 – 5821Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi585 – 5851Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct-1
ORF Names:NCU02063
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
BLAST
Chaini26 – 805780Mitochondrial intermediate peptidasePRO_0000338590Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU02063.1.

Structurei

3D structure databases

ProteinModelPortaliQ7SDD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
InParanoidiQ7SDD5.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7SDD5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQPLVKASR PRLWVCSDCL LRRTLSPLLR QQRRRFTGFT AHAPKTLTGT
60 70 80 90 100
IPVTHKNGDT KHDDSLLRSI FDSPETWKQF SGDKHGRNVG LFRNAYLTSP
110 120 130 140 150
HGFLDFAHVS LGKARALVDK VLNAQSLDEY RAIVRHLDRL SDILCRVLDM
160 170 180 190 200
ADFVRVTHPD QQIQRTASMA WDMMYEYMNQ LNTMTGLYDQ LVQAMDNPQV
210 220 230 240 250
STTWSEEERM VAEVLKLDFA KSAVHLPKDA RDKFVHLSSA ISQTGTNFIQ
260 270 280 290 300
HMEPKIPYTT VEKSRMMGMD PVEVKRMASM GKVYVQTLSP QASIALRTVR
310 320 330 340 350
DDHARHQLFM ASRTASRRTV HTLEELMLLR GESAKLSGFE SYGHLVLHDR
360 370 380 390 400
MMASTPESVR QFLQALSENT RPQAQQEVAD LTAAKRAHKG GDATLEPWDK
410 420 430 440 450
DFYAESIRQA IKSRQKREDL SSYFSLGTVM QGLSRIFTRL YGIRFVPREP
460 470 480 490 500
MPGETWHPDV RRLDVVSDVE GHVAVLYCDL FYRPLKSPNP AHFTLRCSRE
510 520 530 540 550
LSPHEIAETA HTQAENPHVL IPSFESAEFA ANDGMAYSRS QDGAIKQLPT
560 570 580 590 600
IALVCDFPQQ SHNRPALLSF FQLETLFHEM GHAIHSILAR TSFQNVSGTR
610 620 630 640 650
CATDLAELPS TLMEYFAADP SVLALFARHY ETDNPLPYEW VDNKIREARR
660 670 680 690 700
FEALDTENQI ILAMLDQELH SSKAVQGHID STEIFHSLQR QFSTAPPDPQ
710 720 730 740 750
GTAWQGFFGH LVGYGSTYYS YLFDRVLAQR VWNVVFNSGQ GGAALQRENG
760 770 780 790 800
ERLKENLLKW GGSKDPWKCL AGALKDERLE GGGEKAMKLV GSWGGQRGTK

SDQAV
Length:805
Mass (Da):91,095
Last modified:December 15, 2003 - v1
Checksum:i8F2F597AB9BD2130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA34783.1.
RefSeqiXP_964019.1. XM_958926.1.

Genome annotation databases

EnsemblFungiiEFNCRT00000001042; EFNCRP00000001042; EFNCRG00000001041.
GeneIDi3880168.
KEGGincr:NCU02063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA34783.1 .
RefSeqi XP_964019.1. XM_958926.1.

3D structure databases

ProteinModelPortali Q7SDD5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU02063.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000001042 ; EFNCRP00000001042 ; EFNCRG00000001041 .
GeneIDi 3880168.
KEGGi ncr:NCU02063.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
InParanoidi Q7SDD5.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiPMIP_NEUCR
AccessioniPrimary (citable) accession number: Q7SDD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3