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Q7SDD5

- PMIP_NEUCR

UniProt

Q7SDD5 - PMIP_NEUCR

Protein

Mitochondrial intermediate peptidase

Gene

oct-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi578 – 5781Zinc; catalyticPROSITE-ProRule annotation
    Active sitei579 – 5791PROSITE-ProRule annotation
    Metal bindingi582 – 5821Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi585 – 5851Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct-1
    ORF Names:NCU02063
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
    BLAST
    Chaini26 – 805780Mitochondrial intermediate peptidasePRO_0000338590Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU02063.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7SDD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7SDD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQPLVKASR PRLWVCSDCL LRRTLSPLLR QQRRRFTGFT AHAPKTLTGT    50
    IPVTHKNGDT KHDDSLLRSI FDSPETWKQF SGDKHGRNVG LFRNAYLTSP 100
    HGFLDFAHVS LGKARALVDK VLNAQSLDEY RAIVRHLDRL SDILCRVLDM 150
    ADFVRVTHPD QQIQRTASMA WDMMYEYMNQ LNTMTGLYDQ LVQAMDNPQV 200
    STTWSEEERM VAEVLKLDFA KSAVHLPKDA RDKFVHLSSA ISQTGTNFIQ 250
    HMEPKIPYTT VEKSRMMGMD PVEVKRMASM GKVYVQTLSP QASIALRTVR 300
    DDHARHQLFM ASRTASRRTV HTLEELMLLR GESAKLSGFE SYGHLVLHDR 350
    MMASTPESVR QFLQALSENT RPQAQQEVAD LTAAKRAHKG GDATLEPWDK 400
    DFYAESIRQA IKSRQKREDL SSYFSLGTVM QGLSRIFTRL YGIRFVPREP 450
    MPGETWHPDV RRLDVVSDVE GHVAVLYCDL FYRPLKSPNP AHFTLRCSRE 500
    LSPHEIAETA HTQAENPHVL IPSFESAEFA ANDGMAYSRS QDGAIKQLPT 550
    IALVCDFPQQ SHNRPALLSF FQLETLFHEM GHAIHSILAR TSFQNVSGTR 600
    CATDLAELPS TLMEYFAADP SVLALFARHY ETDNPLPYEW VDNKIREARR 650
    FEALDTENQI ILAMLDQELH SSKAVQGHID STEIFHSLQR QFSTAPPDPQ 700
    GTAWQGFFGH LVGYGSTYYS YLFDRVLAQR VWNVVFNSGQ GGAALQRENG 750
    ERLKENLLKW GGSKDPWKCL AGALKDERLE GGGEKAMKLV GSWGGQRGTK 800
    SDQAV 805
    Length:805
    Mass (Da):91,095
    Last modified:December 15, 2003 - v1
    Checksum:i8F2F597AB9BD2130
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA34783.1.
    RefSeqiXP_964019.1. XM_958926.1.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000001042; EFNCRP00000001042; EFNCRG00000001041.
    GeneIDi3880168.
    KEGGincr:NCU02063.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002236 Genomic DNA. Translation: EAA34783.1 .
    RefSeqi XP_964019.1. XM_958926.1.

    3D structure databases

    ProteinModelPortali Q7SDD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU02063.1.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000001042 ; EFNCRP00000001042 ; EFNCRG00000001041 .
    GeneIDi 3880168.
    KEGGi ncr:NCU02063.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiPMIP_NEUCR
    AccessioniPrimary (citable) accession number: Q7SDD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3