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Protein

Protein arginine N-methyltransferase 2

Gene

ant-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei199 – 1991S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei228 – 2281S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei328 – 3281S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Arginine N-methyltransferase 1Curated
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:ant-1Curated
Synonyms:rmt2By similarity
ORF Names:NCU08111
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU08111.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Protein arginine N-methyltransferase 2PRO_0000228978Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7SCW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini190 – 429240RMT2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 2556S-adenosyl-L-methionine bindingPROSITE-ProRule annotation
Regioni271 – 2733S-adenosyl-L-methionine bindingPROSITE-ProRule annotation
Regioni308 – 3092S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation
Contains 1 RMT2 (arginine N-methyltransferase 2-like) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214351.
InParanoidiQ7SCW9.
KOiK18477.
OMAiFEYGAGW.
OrthoDBiEOG092C2OT7.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR017408. Arginine_N-MeTrfase_2.
IPR026480. RMT2_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF038148. Arginine_N-mtfrase-2. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51559. SAM_RMT2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SCW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNDSISVR ISEDCPPEIQ RMLTAAWAHD VDTVKKLIDT PEVARGQDPK
60 70 80 90 100
TGESPLHAAI RSCGAPSEDD TPEDHEKAKA TVSELLMWGA IWNDVDNNNE
110 120 130 140 150
TPGCVAARLN RPELYELCVN AGVRAEMLFG LMDGYEALDS DDEDDEEMAE
160 170 180 190 200
GEEAQAEDGE EAPELVAAEE ATQTAEEETP AVFQPPAVNL EEQVTSDKYL
210 220 230 240 250
RSTVAYSDGK LVDDAGNGVM MAWETDIMRR SVDALLPNKE PGKRILNIGF
260 270 280 290 300
GMGIIDGMFA ETKPAVHHII EAHPEVLEYI STPESKFDST WEESGPAPGA
310 320 330 340 350
YRVWEGKWQQ IGLQLLEEGH VYDAIYFDTF GEDYGQLRMF FTEYIPGLLD
360 370 380 390 400
SNGIFGFFNG LGADRQICYD VYTKVAEMHL ADAGLDVEWK EIPVDMKELA
410 420
EADKDGWEGV KRRYWTLDTY RLPVCTFLG
Length:429
Mass (Da):47,726
Last modified:December 15, 2003 - v1
Checksum:i85EF13DAF4EA1C29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA34605.1.
RefSeqiXP_963841.1. XM_958748.1.

Genome annotation databases

EnsemblFungiiEFNCRT00000009648; EFNCRP00000009630; EFNCRG00000009629.
GeneIDi3879990.
KEGGincr:NCU08111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA. Translation: EAA34605.1.
RefSeqiXP_963841.1. XM_958748.1.

3D structure databases

ProteinModelPortaliQ7SCW9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000009648; EFNCRP00000009630; EFNCRG00000009629.
GeneIDi3879990.
KEGGincr:NCU08111.

Organism-specific databases

EuPathDBiFungiDB:NCU08111.

Phylogenomic databases

HOGENOMiHOG000214351.
InParanoidiQ7SCW9.
KOiK18477.
OMAiFEYGAGW.
OrthoDBiEOG092C2OT7.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR017408. Arginine_N-MeTrfase_2.
IPR026480. RMT2_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF038148. Arginine_N-mtfrase-2. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51559. SAM_RMT2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRMT2_NEUCR
AccessioniPrimary (citable) accession number: Q7SCW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 15, 2003
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.