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Protein

Protein arginine N-methyltransferase 2

Gene

ant-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei199S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei228S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei328S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Arginine N-methyltransferase 1Curated
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:ant-1Curated
Synonyms:rmt2By similarity
ORF Names:NCU08111
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU08111

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289781 – 429Protein arginine N-methyltransferase 2Add BLAST429

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7SCW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini190 – 429RMT2PROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni250 – 255S-adenosyl-L-methionine bindingPROSITE-ProRule annotation6
Regioni271 – 273S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni308 – 309S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214351
InParanoidiQ7SCW9
KOiK18477
OMAiSGAIWND
OrthoDBiEOG092C2OT7

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017408 Arginine_N-MeTrfase_2
IPR026480 RMT2_dom
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF038148 Arginine_N-mtfrase-2, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51559 SAM_RMT2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7SCW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNDSISVR ISEDCPPEIQ RMLTAAWAHD VDTVKKLIDT PEVARGQDPK
60 70 80 90 100
TGESPLHAAI RSCGAPSEDD TPEDHEKAKA TVSELLMWGA IWNDVDNNNE
110 120 130 140 150
TPGCVAARLN RPELYELCVN AGVRAEMLFG LMDGYEALDS DDEDDEEMAE
160 170 180 190 200
GEEAQAEDGE EAPELVAAEE ATQTAEEETP AVFQPPAVNL EEQVTSDKYL
210 220 230 240 250
RSTVAYSDGK LVDDAGNGVM MAWETDIMRR SVDALLPNKE PGKRILNIGF
260 270 280 290 300
GMGIIDGMFA ETKPAVHHII EAHPEVLEYI STPESKFDST WEESGPAPGA
310 320 330 340 350
YRVWEGKWQQ IGLQLLEEGH VYDAIYFDTF GEDYGQLRMF FTEYIPGLLD
360 370 380 390 400
SNGIFGFFNG LGADRQICYD VYTKVAEMHL ADAGLDVEWK EIPVDMKELA
410 420
EADKDGWEGV KRRYWTLDTY RLPVCTFLG
Length:429
Mass (Da):47,726
Last modified:December 15, 2003 - v1
Checksum:i85EF13DAF4EA1C29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA Translation: EAA34605.1
RefSeqiXP_963841.1, XM_958748.1

Genome annotation databases

EnsemblFungiiEAA34605; EAA34605; NCU08111
GeneIDi3879990
KEGGincr:NCU08111

Similar proteinsi

Entry informationi

Entry nameiRMT2_NEUCR
AccessioniPrimary (citable) accession number: Q7SCW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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