Q7SBX8 (CWC27_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl isomerase cwc-27
Short name=PPIase cwc-27
EC=5.2.1.8

Alternative name(s):
Rotamase cwc-27

Gene names

Name:	cwc-27
ORF Names:	B18P7.140, NCU08514

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Associated with the spliceosome By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 541	541	Peptidyl-prolyl isomerase cwc-27		PRO_0000064186
Regions
	Domain	11 – 193	183	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	Q7SBX8 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 6BAC7ECAB92D1664	FASTA	541	60,296
	10 20 30 40 50 60 MSAIYNLEPQ PTASAIIHTT QGEIAVELFA KQTPLTCRNF LQLALDGYYD NTIFHRLIPG 70 80 90 100 110 120 FIVQGGDPSG TGHGGESIYD NGALSGDLDP WPMDQRRGKN AGPHGVNFKD EFHSRLKFNR 130 140 150 160 170 180 RGLLGMANEG APDTNSSQFF FTLGKADELT GKNTMFGRVA GDTIYNLAKI GEAEVEEGGE 190 200 210 220 230 240 RPLYPIKITR IEILINPFDD MQKREKKPRP QQISRPTPAE KKQKKRKGGK QLLSFGDEVG 250 260 270 280 290 300 DEDGEELPLP KKPKFDTRIV ADLDQDDSSK QSASKKSSAK RDAKPVANDV PKREEKPEPK 310 320 330 340 350 360 PVKESRRSPS PQPVAQKKEQ PPKKHYSEHS SPEPEEPKKK SLLEKTNEEI AALKASMKRT 370 380 390 400 410 420 IHSEPVKQEK KKSALEQLIP DTAIRGRKRR PGASSNPTRE EQEALDLLKS FKAKIETAPP 430 440 450 460 470 480 EKNAAQPAVN PDVEDGEQDG QADEEKVCDL HFIANCQSCK AWDKVEDNED SGDEGWMSHK 490 500 510 520 530 540 LSFAADKLGK DLSYRKKAEE ELVVIDPLAK ARTLKEEKKA TRDAKTGGSS RAWDRGRRDR H

References

[1]

"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

[2]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000054 Genomic DNA. Translation: EAA33928.1. BX842594 Genomic DNA. Translation: CAE75687.1.
RefSeq	XP_963164.1. XM_958071.1.
3D structure databases
ProteinModelPortal	Q7SBX8.
SMR	Q7SBX8. Positions 6-199.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000008508; EFNCRP00000008494; EFNCRG00000008494.
GeneID	3879312.
KEGG	ncr:NCU08514.
NMPDR	fig|5141.1.peg.7492.
Phylogenomic databases
eggNOG	fuNOG06026.
GeneTree	EFGT00050000000590.
OMA	FIANCQS.
OrthoDB	EOG4XD70H.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
KO	K12737.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CWC27_NEUCR

Accession

Primary (citable) accession number: Q7SBX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program