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Q7SBJ9

- SET9_NEUCR

UniProt

Q7SBJ9 - SET9_NEUCR

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Protein

Histone-lysine N-methyltransferase set9

Gene

hlm-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates 'Lys-20' of histone H4.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H4-K20 specific) Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase set9 (EC:2.1.1.43)
Alternative name(s):
Histone-lysine methyltransferase 1
SET domain protein 9
Gene namesi
Name:hlm-1
Synonyms:set9
ORF Names:NCU08551
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Histone-lysine N-methyltransferase set9PRO_0000281805Add
BLAST

Proteomic databases

PRIDEiQ7SBJ9.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU08551.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 231115SETPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG314679.
HOGENOMiHOG000214006.
InParanoidiQ7SBJ9.
KOiK11429.
OMAiFMGPARF.
OrthoDBiEOG7T7H51.

Family and domain databases

InterProiIPR025783. Hist-Lys_N-MeTrfase_SET9.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51567. SAM_MT43_SUVAR420_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SBJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPQGTGGK KKNQLTLAQL AAYDDILTDA LVDHAYYWTT IPKNRTSYHP
60 70 80 90 100
SRGIKEEEIT KIIQNHLIVD PDIATAEEKL LATDGLKRFC NTLKTPREQN
110 120 130 140 150
DFKAHLRRYM SIYLPDCPFE VNATNRYTIV TYEASITARR FIQRNETIKY
160 170 180 190 200
LAGIQVVITP EEELEMSLRK KDFSLIVSSR SKSTSLFMGP ARFANHDCNA
210 220 230 240 250
NARLITRGQA GIEIIACRNI EVGEEITVTY SESYFGENNC DCLCATCESN
260 270 280 290 300
LRNGWRPVDG EAAVQKSIED EQPTESSTPY SFRRKRRYGS TALQASRTPS
310 320 330 340 350
VTPDMRPRVL RKSQSQMMLG ERTSTTDSAA QGAGADGQSR KRALEMGTPP
360 370 380 390 400
FTPTKKQKTT QYPVVPIALS TAPSRGSSDN ETSKSPLSFS TTNDNVTDAT
410 420 430 440 450
SQGSESPGPI ILSPEPTPIK QAIGLLKQEE GVNEVAVQQV PEAFTPPPSQ
460 470 480 490 500
PTEEEPPMVR PAFERLAARD RMSIANLISG PSSPAPPVVF SVAEVTTHRP
510 520 530 540 550
KPQTLQLQKT DQTATISTLQ TVTAAVQKEA PVVKTESPIK PTVGQVEKIT
560 570 580 590 600
QVQTTTKSCT PSKPKAQAAA LPQHHMPVST APRGRVPHDY TLTPLLLSEP
610 620 630 640 650
ETAWIMCTHC ASAFVQKNAY LTKSTCPRCE RHSKLYGYMW PKTEKYGPND
660 670 680 690 700
KEERILDHRM INRFLTAEEE ARARGRVYWR ERMGSKGKQG SSAPSTKGTP
710 720 730 740 750
AGEKNEQSAK QEQSQGQYVQ ERFAVRKKVK VQVRSTVPTP VIMTKKDEVA
760 770
EAAALGLRRS GRARRVSAKL ADCELDF
Length:777
Mass (Da):86,094
Last modified:March 19, 2014 - v2
Checksum:iF15745E5259F5AA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA33797.2.
RefSeqiXP_963033.1. XM_957940.1.
UniGeneiNcr.24728.

Genome annotation databases

EnsemblFungiiEFNCRT00000004675; EFNCRP00000004675; EFNCRG00000004669.
GeneIDi3879172.
KEGGincr:NCU08551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA33797.2 .
RefSeqi XP_963033.1. XM_957940.1.
UniGenei Ncr.24728.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU08551.1.

Proteomic databases

PRIDEi Q7SBJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000004675 ; EFNCRP00000004675 ; EFNCRG00000004669 .
GeneIDi 3879172.
KEGGi ncr:NCU08551.

Phylogenomic databases

eggNOGi NOG314679.
HOGENOMi HOG000214006.
InParanoidi Q7SBJ9.
KOi K11429.
OMAi FMGPARF.
OrthoDBi EOG7T7H51.

Family and domain databases

InterProi IPR025783. Hist-Lys_N-MeTrfase_SET9.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51567. SAM_MT43_SUVAR420_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiSET9_NEUCR
AccessioniPrimary (citable) accession number: Q7SBJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 19, 2014
Last modified: October 29, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3