Q7SBJ9 (SET9_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase set-9
EC=2.1.1.43

Alternative name(s):
SET domain protein 9

Gene names

Name:	set-9
ORF Names:	NCU08551

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	783 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone methyltransferase that specifically methylates 'Lys-20' of histone H4 By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosome Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H4-K20 specific) Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 783	783	Histone-lysine N-methyltransferase set-9		PRO_0000281805
Regions
	Domain	105 – 235	131	SET

Sequences

	Sequence		Length	Mass (Da)
	Q7SBJ9 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 1ACDE79044CC4928	FASTA	783	86,474
	10 20 30 40 50 60 MTKPQGTGGK KKNQLTLAQL AAYDDILTDA LVDHAYYWTT IPKNRTSYHP SRGIKEEEIT 70 80 90 100 110 120 KIIQNHLIVD PDIATAEEKL LATDGLKRFC NTLKTPREQN DFKAHLRRYM SIYLPDCPFE 130 140 150 160 170 180 VNATNRYTIV TYEASITARR FIQRNETIKY LAGIQVVITP EEELEMSLRK KDFSLIVSSR 190 200 210 220 230 240 SKSTSLFMGP ARFANHDCNA NARLITRGQA GIEIIACRNI EVGEEITVTY SESYFGENNC 250 260 270 280 290 300 DCLCATCESN LRNGWRPVDG EAAVQKSIED EQPTESSTPY SFRRKRRYGS TALQASRTPS 310 320 330 340 350 360 VTPDMRPRVL RKSQSQMMLG ERTSTTDSAA QGAGADGQSR KRALEMGTPP FTPTKKQKTT 370 380 390 400 410 420 QYPVVPIALS TAPSRGSSDN ETSKSPLSFS TTNDNVTDAT SQGSESPGPI ILSPEPTPIK 430 440 450 460 470 480 QAIGLLKQEE GVNEVAVQQV PEAFTPPPSQ PTEEEPPMVR PAFERLAARD RMSIANLISG 490 500 510 520 530 540 PSSPAPPVVF SVAEVTTHRP KPQTLQLQKT DQTATISTLQ TVTAAVQKEA PVVKTESPIK 550 560 570 580 590 600 PTVGQVEKIT QVQTTTKSCT PSKPKAQAAA LPQHHMPVST APRGRVPHDY TLTPLLLSEP 610 620 630 640 650 660 ETAWIMCTHC ASAFVQKNAY LTKSTCPRCE RHSKLYGYMW PKTEKYGPND KEERILDHRM 670 680 690 700 710 720 INRFLTAEEE ARARGRVYWR ERMGSKGKQG SSAPSTKGTP AGEKNEQSAK QEQSQGQYVQ 730 740 750 760 770 780 ERFAVRKKVK VQVRSTVPTP VIMTKKDEVA EAAALGLRRS GRARRVSAKL ADSGASTVAD GKN

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000017 Genomic DNA. Translation: EAA33797.1.
RefSeq	XP_963033.1. XM_957940.1.
UniGene	Ncr.24728.
3D structure databases
ProteinModelPortal	Q7SBJ9.
ModBase	Search...
Proteomic databases
PRIDE	Q7SBJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000004675; EFNCRP00000004675; EFNCRG00000004669.
GeneID	3879172.
KEGG	ncr:NCU08551.
Phylogenomic databases
eggNOG	NOG314679.
HOGENOM	HOG000214006.
KO	K11429.
OMA	GPARFAN.
OrthoDB	EOG40GH04.
Family and domain databases
InterPro	IPR025783. Hist-Lys_N-MeTrfase_SET9. IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET9_NEUCR

Accession

Primary (citable) accession number: Q7SBJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program