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Q7SBJ9

- SET9_NEUCR

UniProt

Q7SBJ9 - SET9_NEUCR

Protein

Histone-lysine N-methyltransferase set9

Gene

hlm-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates 'Lys-20' of histone H4.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone methyltransferase activity (H4-K20 specific) Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase set9 (EC:2.1.1.43)
    Alternative name(s):
    Histone-lysine methyltransferase 1
    SET domain protein 9
    Gene namesi
    Name:hlm-1
    Synonyms:set9
    ORF Names:NCU08551
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 3, Linkage Group III

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 777777Histone-lysine N-methyltransferase set9PRO_0000281805Add
    BLAST

    Proteomic databases

    PRIDEiQ7SBJ9.

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU08551.1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini117 – 231115SETPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG314679.
    HOGENOMiHOG000214006.
    KOiK11429.
    OMAiFMGPARF.
    OrthoDBiEOG7T7H51.

    Family and domain databases

    InterProiIPR025783. Hist-Lys_N-MeTrfase_SET9.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51567. SAM_MT43_SUVAR420_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SBJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKPQGTGGK KKNQLTLAQL AAYDDILTDA LVDHAYYWTT IPKNRTSYHP    50
    SRGIKEEEIT KIIQNHLIVD PDIATAEEKL LATDGLKRFC NTLKTPREQN 100
    DFKAHLRRYM SIYLPDCPFE VNATNRYTIV TYEASITARR FIQRNETIKY 150
    LAGIQVVITP EEELEMSLRK KDFSLIVSSR SKSTSLFMGP ARFANHDCNA 200
    NARLITRGQA GIEIIACRNI EVGEEITVTY SESYFGENNC DCLCATCESN 250
    LRNGWRPVDG EAAVQKSIED EQPTESSTPY SFRRKRRYGS TALQASRTPS 300
    VTPDMRPRVL RKSQSQMMLG ERTSTTDSAA QGAGADGQSR KRALEMGTPP 350
    FTPTKKQKTT QYPVVPIALS TAPSRGSSDN ETSKSPLSFS TTNDNVTDAT 400
    SQGSESPGPI ILSPEPTPIK QAIGLLKQEE GVNEVAVQQV PEAFTPPPSQ 450
    PTEEEPPMVR PAFERLAARD RMSIANLISG PSSPAPPVVF SVAEVTTHRP 500
    KPQTLQLQKT DQTATISTLQ TVTAAVQKEA PVVKTESPIK PTVGQVEKIT 550
    QVQTTTKSCT PSKPKAQAAA LPQHHMPVST APRGRVPHDY TLTPLLLSEP 600
    ETAWIMCTHC ASAFVQKNAY LTKSTCPRCE RHSKLYGYMW PKTEKYGPND 650
    KEERILDHRM INRFLTAEEE ARARGRVYWR ERMGSKGKQG SSAPSTKGTP 700
    AGEKNEQSAK QEQSQGQYVQ ERFAVRKKVK VQVRSTVPTP VIMTKKDEVA 750
    EAAALGLRRS GRARRVSAKL ADCELDF 777
    Length:777
    Mass (Da):86,094
    Last modified:March 19, 2014 - v2
    Checksum:iF15745E5259F5AA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA33797.2.
    RefSeqiXP_963033.1. XM_957940.1.
    UniGeneiNcr.24728.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000004675; EFNCRP00000004675; EFNCRG00000004669.
    GeneIDi3879172.
    KEGGincr:NCU08551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA33797.2 .
    RefSeqi XP_963033.1. XM_957940.1.
    UniGenei Ncr.24728.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU08551.1.

    Proteomic databases

    PRIDEi Q7SBJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000004675 ; EFNCRP00000004675 ; EFNCRG00000004669 .
    GeneIDi 3879172.
    KEGGi ncr:NCU08551.

    Phylogenomic databases

    eggNOGi NOG314679.
    HOGENOMi HOG000214006.
    KOi K11429.
    OMAi FMGPARF.
    OrthoDBi EOG7T7H51.

    Family and domain databases

    InterProi IPR025783. Hist-Lys_N-MeTrfase_SET9.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51567. SAM_MT43_SUVAR420_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiSET9_NEUCR
    AccessioniPrimary (citable) accession number: Q7SBJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3