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Q7SBJ9 (SET9_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase set9

EC=2.1.1.43
Alternative name(s):
Histone-lysine methyltransferase 1
SET domain protein 9
Gene names
Name:hlm-1
Synonyms:set9
ORF Names:NCU08551
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length777 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates 'Lys-20' of histone H4 By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Contains 1 SET domain.

Ontologies

Keywords
   Cellular componentChromosome
Nucleus
   LigandS-adenosyl-L-methionine
   Molecular functionChromatin regulator
Methyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentchromosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone methyltransferase activity (H4-K20 specific)

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 777777Histone-lysine N-methyltransferase set9
PRO_0000281805

Regions

Domain117 – 231115SET

Sequences

Sequence LengthMass (Da)Tools
Q7SBJ9 [UniParc].

Last modified March 19, 2014. Version 2.
Checksum: F15745E5259F5AA0

FASTA77786,094
        10         20         30         40         50         60 
MTKPQGTGGK KKNQLTLAQL AAYDDILTDA LVDHAYYWTT IPKNRTSYHP SRGIKEEEIT 

        70         80         90        100        110        120 
KIIQNHLIVD PDIATAEEKL LATDGLKRFC NTLKTPREQN DFKAHLRRYM SIYLPDCPFE 

       130        140        150        160        170        180 
VNATNRYTIV TYEASITARR FIQRNETIKY LAGIQVVITP EEELEMSLRK KDFSLIVSSR 

       190        200        210        220        230        240 
SKSTSLFMGP ARFANHDCNA NARLITRGQA GIEIIACRNI EVGEEITVTY SESYFGENNC 

       250        260        270        280        290        300 
DCLCATCESN LRNGWRPVDG EAAVQKSIED EQPTESSTPY SFRRKRRYGS TALQASRTPS 

       310        320        330        340        350        360 
VTPDMRPRVL RKSQSQMMLG ERTSTTDSAA QGAGADGQSR KRALEMGTPP FTPTKKQKTT 

       370        380        390        400        410        420 
QYPVVPIALS TAPSRGSSDN ETSKSPLSFS TTNDNVTDAT SQGSESPGPI ILSPEPTPIK 

       430        440        450        460        470        480 
QAIGLLKQEE GVNEVAVQQV PEAFTPPPSQ PTEEEPPMVR PAFERLAARD RMSIANLISG 

       490        500        510        520        530        540 
PSSPAPPVVF SVAEVTTHRP KPQTLQLQKT DQTATISTLQ TVTAAVQKEA PVVKTESPIK 

       550        560        570        580        590        600 
PTVGQVEKIT QVQTTTKSCT PSKPKAQAAA LPQHHMPVST APRGRVPHDY TLTPLLLSEP 

       610        620        630        640        650        660 
ETAWIMCTHC ASAFVQKNAY LTKSTCPRCE RHSKLYGYMW PKTEKYGPND KEERILDHRM 

       670        680        690        700        710        720 
INRFLTAEEE ARARGRVYWR ERMGSKGKQG SSAPSTKGTP AGEKNEQSAK QEQSQGQYVQ 

       730        740        750        760        770 
ERFAVRKKVK VQVRSTVPTP VIMTKKDEVA EAAALGLRRS GRARRVSAKL ADCELDF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002238 Genomic DNA. Translation: EAA33797.2.
RefSeqXP_963033.1. XM_957940.1.
UniGeneNcr.24728.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU08551.1.

Proteomic databases

PRIDEQ7SBJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000004675; EFNCRP00000004675; EFNCRG00000004669.
GeneID3879172.
KEGGncr:NCU08551.

Phylogenomic databases

eggNOGNOG314679.
HOGENOMHOG000214006.
KOK11429.
OMAFMGPARF.
OrthoDBEOG7T7H51.

Family and domain databases

InterProIPR025783. Hist-Lys_N-MeTrfase_SET9.
IPR001214. SET_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
[Graphical view]
SMARTSM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51567. SAM_MT43_SUVAR420_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET9_NEUCR
AccessionPrimary (citable) accession number: Q7SBJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 19, 2014
Last modified: June 11, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families