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Q7SBD4

- EIF3C_NEUCR

UniProt

Q7SBD4 - EIF3C_NEUCR

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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

nip-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 93 kDa subunit homologUniRule annotation
Short name:
eIF3 p93UniRule annotation
Translation initiation factor eIF3, p93 subunit homologUniRule annotation
Gene namesi
Name:nip-1
ORF Names:NCU07831
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 872872Eukaryotic translation initiation factor 3 subunit CPRO_0000364287Add
BLAST

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi5141.NCU07831.1.

Structurei

3D structure databases

ProteinModelPortaliQ7SBD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini654 – 784131PCIUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG305883.
HOGENOMiHOG000029414.
InParanoidiQ7SBD4.
KOiK03252.
OMAiENLHNVD.
OrthoDBiEOG75QRCP.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7SBD4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSRFFRGGDD SSTDSSSEEE EVYTSEEEEE KVQAEDESSS EEESDEEESD
60 70 80 90 100
EESSSDEEEG TKKKGASRFL QSDDESEEEE EEQSDDEATT KVKSAKDKRF
110 120 130 140 150
DELESTISQI QNGQKINDWS LIANEFDKLN RQVVKLQDGS KAPKSYIKAI
160 170 180 190 200
ADLEDFMNET LAKQKVTPKK MNATNARGLN AVKQRIRKNN KEYQTQIDAY
210 220 230 240 250
RKDADAFMES DDEVAAPKVV SKVRFEAPVV SAEQQEEDDK GFSTVDSRGK
260 270 280 290 300
VVQYTPESIL KHLRAIIESR GKKNTDRLEQ IKVMETLNKV VPITPYQKIR
310 320 330 340 350
VLQTLISARF DLGAGGAAQM PLDQWKAAER DLASLLEILE KEKDHVVVEG
360 370 380 390 400
AEEWDDDDKL PTIPEGEKYL KVPGSVVSLI ERLDDELTRS LQAIDPHTSE
410 420 430 440 450
YIDRLTDEGS LYNTIFRGLL YYEHLRKDAS LEVPQESLNR IIQRRLDHVY
460 470 480 490 500
YKPAQVVKIL EENAWKQVSA EADSEITPRS QSGDAGKLIN ILSNYLFENS
510 520 530 540 550
EGIIRARAML CQIYFLALHD EYYKSRDLML TSHLQETIAN FDIATQILYN
560 570 580 590 600
RTLVQVGLCA FRKGLVYDAQ NTLQEICGSG RQKELLAQGV MIQRYSQVTP
610 620 630 640 650
EQERLEKQRQ LPFHMHINLE LLECVYLTCS MLLEIPLLAQ TGSSPDVKKR
660 670 680 690 700
IISKTYRRML EYHERQIFTG PPENTRDHVM QASKALAAGE WKKATDFIHS
710 720 730 740 750
IKIWDLMPNT EGIKTMLAKQ IQEEGLRTYL FTYAPFYDTL AIATLSSMFE
760 770 780 790 800
LDSRKVSAVV SKMISHEELA AALDQVTETV IFRKGVELSR LQSLALTLSD
810 820 830 840 850
KASSLIETNE RTLEQKTQGS ANAFSRKDNR GGGQRGGGQR GGRGGARTGG
860 870
NPQRQAGGTQ FTGGALGNAV RG
Length:872
Mass (Da):98,399
Last modified:December 15, 2003 - v1
Checksum:i38611B9B0CC93EA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA33716.1.
RefSeqiXP_962952.1. XM_957859.2.
UniGeneiNcr.23166.

Genome annotation databases

EnsemblFungiiEFNCRT00000007481; EFNCRP00000007471; EFNCRG00000007469.
GeneIDi3879100.
KEGGincr:NCU07831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA33716.1 .
RefSeqi XP_962952.1. XM_957859.2.
UniGenei Ncr.23166.

3D structure databases

ProteinModelPortali Q7SBD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU07831.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000007481 ; EFNCRP00000007471 ; EFNCRG00000007469 .
GeneIDi 3879100.
KEGGi ncr:NCU07831.

Phylogenomic databases

eggNOGi NOG305883.
HOGENOMi HOG000029414.
InParanoidi Q7SBD4.
KOi K03252.
OMAi ENLHNVD.
OrthoDBi EOG75QRCP.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_03002. eIF3c.
InterProi IPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view ]
SMARTi SM00088. PINT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiEIF3C_NEUCR
AccessioniPrimary (citable) accession number: Q7SBD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3