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Q7SBD4

- EIF3C_NEUCR

UniProt

Q7SBD4 - EIF3C_NEUCR

Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

nip-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
    2. regulation of translational initiation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit CUniRule annotation
    Short name:
    eIF3cUniRule annotation
    Alternative name(s):
    Eukaryotic translation initiation factor 3 93 kDa subunit homologUniRule annotation
    Short name:
    eIF3 p93UniRule annotation
    Translation initiation factor eIF3, p93 subunit homologUniRule annotation
    Gene namesi
    Name:nip-1
    ORF Names:NCU07831
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 3, Linkage Group III

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
    2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
    3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 872872Eukaryotic translation initiation factor 3 subunit CPRO_0000364287Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi5141.NCU07831.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7SBD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini654 – 784131PCIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-3 subunit C family.UniRule annotation
    Contains 1 PCI domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG305883.
    HOGENOMiHOG000029414.
    KOiK03252.
    OMAiENLHNVD.
    OrthoDBiEOG75QRCP.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_03002. eIF3c.
    InterProiIPR027516. EIF3C.
    IPR008905. EIF3C_N_dom.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05470. eIF-3c_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view]
    SMARTiSM00088. PINT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7SBD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRFFRGGDD SSTDSSSEEE EVYTSEEEEE KVQAEDESSS EEESDEEESD    50
    EESSSDEEEG TKKKGASRFL QSDDESEEEE EEQSDDEATT KVKSAKDKRF 100
    DELESTISQI QNGQKINDWS LIANEFDKLN RQVVKLQDGS KAPKSYIKAI 150
    ADLEDFMNET LAKQKVTPKK MNATNARGLN AVKQRIRKNN KEYQTQIDAY 200
    RKDADAFMES DDEVAAPKVV SKVRFEAPVV SAEQQEEDDK GFSTVDSRGK 250
    VVQYTPESIL KHLRAIIESR GKKNTDRLEQ IKVMETLNKV VPITPYQKIR 300
    VLQTLISARF DLGAGGAAQM PLDQWKAAER DLASLLEILE KEKDHVVVEG 350
    AEEWDDDDKL PTIPEGEKYL KVPGSVVSLI ERLDDELTRS LQAIDPHTSE 400
    YIDRLTDEGS LYNTIFRGLL YYEHLRKDAS LEVPQESLNR IIQRRLDHVY 450
    YKPAQVVKIL EENAWKQVSA EADSEITPRS QSGDAGKLIN ILSNYLFENS 500
    EGIIRARAML CQIYFLALHD EYYKSRDLML TSHLQETIAN FDIATQILYN 550
    RTLVQVGLCA FRKGLVYDAQ NTLQEICGSG RQKELLAQGV MIQRYSQVTP 600
    EQERLEKQRQ LPFHMHINLE LLECVYLTCS MLLEIPLLAQ TGSSPDVKKR 650
    IISKTYRRML EYHERQIFTG PPENTRDHVM QASKALAAGE WKKATDFIHS 700
    IKIWDLMPNT EGIKTMLAKQ IQEEGLRTYL FTYAPFYDTL AIATLSSMFE 750
    LDSRKVSAVV SKMISHEELA AALDQVTETV IFRKGVELSR LQSLALTLSD 800
    KASSLIETNE RTLEQKTQGS ANAFSRKDNR GGGQRGGGQR GGRGGARTGG 850
    NPQRQAGGTQ FTGGALGNAV RG 872
    Length:872
    Mass (Da):98,399
    Last modified:December 15, 2003 - v1
    Checksum:i38611B9B0CC93EA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA33716.1.
    RefSeqiXP_962952.1. XM_957859.2.
    UniGeneiNcr.23166.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000007481; EFNCRP00000007471; EFNCRG00000007469.
    GeneIDi3879100.
    KEGGincr:NCU07831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA33716.1 .
    RefSeqi XP_962952.1. XM_957859.2.
    UniGenei Ncr.23166.

    3D structure databases

    ProteinModelPortali Q7SBD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU07831.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000007481 ; EFNCRP00000007471 ; EFNCRG00000007469 .
    GeneIDi 3879100.
    KEGGi ncr:NCU07831.

    Phylogenomic databases

    eggNOGi NOG305883.
    HOGENOMi HOG000029414.
    KOi K03252.
    OMAi ENLHNVD.
    OrthoDBi EOG75QRCP.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_03002. eIF3c.
    InterProi IPR027516. EIF3C.
    IPR008905. EIF3C_N_dom.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05470. eIF-3c_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view ]
    SMARTi SM00088. PINT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiEIF3C_NEUCR
    AccessioniPrimary (citable) accession number: Q7SBD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3