Q7SBD4 (EIF3C_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 3 subunit C
Short name=eIF3c

Alternative name(s):
Eukaryotic translation initiation factor 3 93 kDa subunit homolog
Short name=eIF3 p93
Translation initiation factor eIF3, p93 subunit homolog

Gene names

Name:	nip-1
ORF Names:	NCU07831

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	872 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03002
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eIF-3 subunit C family. Contains 1 PCI domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	eukaryotic translation initiation factor 3 complex Inferred from electronic annotation. Source: InterPro
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 872	872	Eukaryotic translation initiation factor 3 subunit C HAMAP-Rule MF_03002		PRO_0000364287
Regions
	Domain	654 – 784	131	PCI

Sequences

	Sequence		Length	Mass (Da)
	Q7SBD4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 38611B9B0CC93EA1	FASTA	872	98,399
	10 20 30 40 50 60 MSRFFRGGDD SSTDSSSEEE EVYTSEEEEE KVQAEDESSS EEESDEEESD EESSSDEEEG 70 80 90 100 110 120 TKKKGASRFL QSDDESEEEE EEQSDDEATT KVKSAKDKRF DELESTISQI QNGQKINDWS 130 140 150 160 170 180 LIANEFDKLN RQVVKLQDGS KAPKSYIKAI ADLEDFMNET LAKQKVTPKK MNATNARGLN 190 200 210 220 230 240 AVKQRIRKNN KEYQTQIDAY RKDADAFMES DDEVAAPKVV SKVRFEAPVV SAEQQEEDDK 250 260 270 280 290 300 GFSTVDSRGK VVQYTPESIL KHLRAIIESR GKKNTDRLEQ IKVMETLNKV VPITPYQKIR 310 320 330 340 350 360 VLQTLISARF DLGAGGAAQM PLDQWKAAER DLASLLEILE KEKDHVVVEG AEEWDDDDKL 370 380 390 400 410 420 PTIPEGEKYL KVPGSVVSLI ERLDDELTRS LQAIDPHTSE YIDRLTDEGS LYNTIFRGLL 430 440 450 460 470 480 YYEHLRKDAS LEVPQESLNR IIQRRLDHVY YKPAQVVKIL EENAWKQVSA EADSEITPRS 490 500 510 520 530 540 QSGDAGKLIN ILSNYLFENS EGIIRARAML CQIYFLALHD EYYKSRDLML TSHLQETIAN 550 560 570 580 590 600 FDIATQILYN RTLVQVGLCA FRKGLVYDAQ NTLQEICGSG RQKELLAQGV MIQRYSQVTP 610 620 630 640 650 660 EQERLEKQRQ LPFHMHINLE LLECVYLTCS MLLEIPLLAQ TGSSPDVKKR IISKTYRRML 670 680 690 700 710 720 EYHERQIFTG PPENTRDHVM QASKALAAGE WKKATDFIHS IKIWDLMPNT EGIKTMLAKQ 730 740 750 760 770 780 IQEEGLRTYL FTYAPFYDTL AIATLSSMFE LDSRKVSAVV SKMISHEELA AALDQVTETV 790 800 810 820 830 840 IFRKGVELSR LQSLALTLSD KASSLIETNE RTLEQKTQGS ANAFSRKDNR GGGQRGGGQR 850 860 870 GGRGGARTGG NPQRQAGGTQ FTGGALGNAV RG

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000040 Genomic DNA. Translation: EAA33716.1.
RefSeq	XP_962952.1. XM_957859.2.
UniGene	Ncr.23166.
3D structure databases
ProteinModelPortal	Q7SBD4.
ModBase	Search...
Protein-protein interaction databases
STRING	5141.NCU07831.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000007481; EFNCRP00000007471; EFNCRG00000007469.
GeneID	3879100.
KEGG	ncr:NCU07831.
Phylogenomic databases
eggNOG	NOG305883.
HOGENOM	HOG000029414.
KO	K03252.
OMA	ESHITNY.
OrthoDB	EOG4578FW.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
HAMAP	MF_03002. eIF3c.
InterPro	IPR008905. eIF3c_N. IPR000717. PCI_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF05470. eIF-3c_N. 1 hit. PF01399. PCI. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EIF3C_NEUCR

Accession

Primary (citable) accession number: Q7SBD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program