Q7SB49 (DNLI4_NEUCR) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA ligase 4 EC=6.5.1.1 Alternative name(s): DNA ligase IV DNA repair and recombination protein mus-53 Polydeoxyribonucleotide synthase [ATP] 4 | ||||||
| Gene names |
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| Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome] | ||||||
| Taxonomic identifier | 367110 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › ![]() |
Protein attributes
| Sequence length | 1046 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Ref.1 |
| Catalytic activity | ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). |
| Cofactor | Magnesium By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the ATP-dependent DNA ligase family. Contains 2 BRCT domains. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1046 | 1046 | DNA ligase 4 | PRO_0000278384 | |||||
Regions | |||||||||
| Domain | 738 – 836 | 99 | BRCT 1 | ||||||
| Domain | 932 – 1045 | 114 | BRCT 2 | ||||||
Sites | |||||||||
| Active site | 327 | 1 | N6-AMP-lysine intermediate By similarity | ||||||
| Metal binding | 394 | 1 | Magnesium 1 Potential | ||||||
| Metal binding | 494 | 1 | Magnesium 2 Potential | ||||||
| Binding site | 325 | 1 | ATP By similarity | ||||||
| Binding site | 332 | 1 | ATP By similarity | ||||||
| Binding site | 354 | 1 | ATP By similarity | ||||||
| Binding site | 499 | 1 | ATP By similarity | ||||||
| Binding site | 510 | 1 | ATP By similarity | ||||||
| Binding site | 516 | 1 | ATP By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora." Ishibashi K., Suzuki K., Ando Y., Takakura C., Inoue H. Proc. Natl. Acad. Sci. U.S.A. 103:14871-14876(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. |
| [2] | "The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. Birren B.W.Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB261106 Genomic DNA. Translation: BAF34364.1. AABX02000025 Genomic DNA. Translation: EAA33632.1. |
| RefSeq | XP_962868.1. XM_957775.1. |
| UniGene | Ncr.24770. |
3D structure databases | |
| ProteinModelPortal | Q7SB49. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 5141.NCU06264.1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | EFNCRT00000006055; EFNCRP00000006048; EFNCRG00000006045. |
| GeneID | 3879007. |
| KEGG | ncr:NCU06264. |
Phylogenomic databases | |
| eggNOG | COG1793. |
| HOGENOM | HOG000176213. |
| KO | K10777. |
| OMA | HMCPSTK. |
| OrthoDB | EOG41K2MD. |
Family and domain databases | |
| Gene3D | 1.10.3260.10. 1 hit. 2.40.50.140. 1 hit. 3.40.50.10190. 2 hits. |
| InterPro | IPR001357. BRCT_dom. IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view] |
| Pfam | PF00533. BRCT. 1 hit. PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view] |
| SMART | SM00292. BRCT. 2 hits. [Graphical view] |
| SUPFAM | SSF52113. BRCT. 2 hits. SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit. |
| TIGRFAMs | TIGR00574. dnl1. 1 hit. |
| PROSITE | PS50172. BRCT. 2 hits. PS00697. DNA_LIGASE_A1. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DNLI4_NEUCR | ||||||||
| Accession | Primary (citable) accession number: Q7SB49 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
