Reviewed, UniProtKB/Swiss-Prot Q7SA44 (MTLD_NEUCR)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
      Short name=M1PDH
      Short name=MPDH
      Short name=MPD
    EC=1.1.1.17

Gene names

ORF Names:

NCU07318

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371530
Regions
	Nucleotide binding	10 – 21	12	NAD By similarity
Sites
	Active site	221	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7SA44-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 506D426F92E1A396	FASTA	398	44,372
	10 20 30 40 50 60 MAANNYTKKA VHFGAGNIGR GFVACFLHNS GYEVIFADVN ADLINALNAS PSYKVIEVGS 70 80 90 100 110 120 EGTEESTITN YRAINSRTNE EELIQEIATA EVVTCSVGPN ILKFIAPVIA KGIDRRSEDL 130 140 150 160 170 180 PPVAVIACEN AIGATDTLAE YIKDPKNTPS HRLENYEKRA RFANSAIDRI VPAQDADAGL 190 200 210 220 230 240 DVKLEKFYEW VVDRTPFKDM SPPDIKGINW VDNLLPYIER KLYTVNTGHA TAAYHGYIRR 250 260 270 280 290 300 KSTVYDALQD KDIQEEVKKA LENTSHLITQ KHGIDEQAQH EYVEKIVRRI SNPHLEDAVE 310 320 330 340 350 360 RVGRAPLRKL SRKERFIGPA AELAEHGKDC SALLDAAEMA FRFQNVEGDE ESAELAKIMA 370 380 390 SNKPEDVVKQ VCGLNEQEKL FPKVVEVVQR VQADLHDD

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000036 Genomic DNA. Translation: EAA33240.1.
RefSeq	XP_962476.1.
3D structure databases
SMR	Q7SA44. Positions 4-344.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7SA44.
Genome annotation databases
GeneID	3878624.
KEGG	ncr:NCU07318.
NMPDR	fig|5141.1.peg.5537.
Phylogenomic databases
eggNOG	fuNOG06426.
OrthoDB	EOG90032G.
PhylomeDB	Q7SA44.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_NEUCR

Accession

Primary (citable) accession number: Q7SA44

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	December 15, 2003
Last modified:	January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)