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Protein

Histone acetyltransferase esa-1

Gene

esa-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362Important for catalytic activityBy similarity1
Active sitei396Proton donor/acceptorBy similarity1
Binding sitei400Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri253 – 278C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase esa-1 (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase hat-4
Gene namesi
Name:esa-1
Synonyms:hat-4
ORF Names:NCU05218
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

EuPathDBiFungiDB:NCU05218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515591 – 506Histone acetyltransferase esa-1Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-320 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7S9B6
SMRiQ7S9B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 494MYST-type HATPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni361 – 365Acetyl-CoA bindingBy similarity5
Regioni370 – 376Acetyl-CoA bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi303 – 324ESA1-RPD3 motifBy similarityAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 121Lys-richAdd BLAST32

Domaini

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri253 – 278C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000182457
InParanoidiQ7S9B6
KOiK11304
OMAiIRPWYFS
OrthoDBiEOG092C043Q

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR037995 Esa1/KAT5/Tip60
IPR002717 HAT_MYST-type
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR10615:SF124 PTHR10615:SF124, 1 hit
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q7S9B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPGGDATV GSDEKRQKGK ATPDTIKMGC IAMVMKEGQL RRAEILSIKD
60 70 80 90 100
TKSGRQFYCN FDNFNKRLDE WVPAARIDFE QDVEWPNPDK DKQKDAKTKK
110 120 130 140 150
NNSTVSKKQP SKKNNQKKAS KREQSVASDG QTPHPWTEFV ESQPGKNNRQ
160 170 180 190 200
RGKTEDGTDV NASLEVGGDK GVKRKADEID MDEDEIPAAK KQRQPSFSRE
210 220 230 240 250
QEIEKLRTSG SMTQNPTEIS RIRNISKVEF GRYVLFPWYF SPYPQIFDQE
260 270 280 290 300
DCIYICEFCL SYYGELKSFV RHRQKCTLHH PPGNEIYRDD YVSFFEIDGR
310 320 330 340 350
RQRTWCRNLC LLSKMFLDHK TLYYDVDPFL FYVMTTRDDR GCHIIGYFSK
360 370 380 390 400
EKESTDGYNV ACILTLPQYQ RKGYGRLLIQ FSYELSKIEG KLGSPEKPLS
410 420 430 440 450
DLGLLSYRQY WSENIIDILL GYNERKEACT IENIAVALAM TTQDVEHTLQ
460 470 480 490 500
ALKMQVYHKG EHKIVVPEKL IKQREKSKAK QKRLIDPERI QWKPPVFTAL

NRTWGW
Length:506
Mass (Da):58,807
Last modified:December 15, 2003 - v1
Checksum:i53A62414D139674A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002239 Genomic DNA Translation: EAA32981.1
RefSeqiXP_962217.1, XM_957124.2

Genome annotation databases

EnsemblFungiiEAA32981; EAA32981; NCU05218
GeneIDi3878365
KEGGincr:NCU05218

Similar proteinsi

Entry informationi

Entry nameiESA1_NEUCR
AccessioniPrimary (citable) accession number: Q7S9B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health