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Q7S986 (G6PI_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi-1
Synonyms:emp-2, gpi-1
ORF Names:NCU07281
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180576

Sites

Active site3701Proton donor By similarity
Active site4011 By similarity
Active site5251 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7S986 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: F21908EC4F38884C

FASTA56161,398
        10         20         30         40         50         60 
MAPANTLSAW SDLQSHHSKV GKTFVLKDAF KSDPERFSKF ARTFTLPADI SSDSPNATDI 

        70         80         90        100        110        120 
LFDFSKNLVT EETLDKLVRL AEEAGVEKKR DAMFAGEKIN FTEDRAVYHV ALRNVSNQEM 

       130        140        150        160        170        180 
KVDGVDVMNT KGGVNEVLQH MKEFSEQVRS GEWKGYTGKK LTNIINIGIG GSDLGPVMVT 

       190        200        210        220        230        240 
EALKHYGAKD MTLRFVSNVD GTHIAEALAA SDPETTLFLI ASKTFTTAET ITNANTAKSW 

       250        260        270        280        290        300 
FLEKTGGQGD ITKHFVALST NEAEVTKFGI DAKNMFGFES WVGGRYSVWS AIGLSVALYV 

       310        320        330        340        350        360 
GYENFHKFLA GAHAMDNHFR TAPLKENIPV LGGILSVWYS NFYNAQTHLI APFDQYLHRF 

       370        380        390        400        410        420 
PAYLQQLSME SNGKSITSDG SAAKYTTGPI VFGEPCTNAQ HSFFQLVHQG TKLIPADFIL 

       430        440        450        460        470        480 
AAKSHNPISN NLHQKMLASN YLAQAEALMV GKTAEEVRAE GNVPEHLVPH KVFLGNRPTT 

       490        500        510        520        530        540 
SILVGGHIGP AELGALIVYY EHLTFTEGAI WDINSFDQWG VELGKVLAKK ILKEIDEPGA 

       550        560 
GSGHDASTGG LLGAFKKYAD F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002239 Genomic DNA. Translation: EAA32899.1.
RefSeqXP_962135.1. XM_957042.2.
UniGeneNcr.11301.

3D structure databases

ProteinModelPortalQ7S986.
SMRQ7S986. Positions 4-559.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU07281.1.

Proteomic databases

PRIDEQ7S986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000007110; EFNCRP00000007100; EFNCRG00000007098.
GeneID3878284.
KEGGncr:NCU07281.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261371.
KOK01810.
OMAISIYESN.
OrthoDBEOG7N0CDV.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_NEUCR
AccessionPrimary (citable) accession number: Q7S986
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways