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Q7S986

- G6PI_NEUCR

UniProt

Q7S986 - G6PI_NEUCR

Protein

Glucose-6-phosphate isomerase

Gene

pgi-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei370 – 3701Proton donorBy similarity
    Active sitei401 – 4011By similarity
    Active sitei525 – 5251By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi-1
    Synonyms:emp-2, gpi-1
    ORF Names:NCU07281
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 4, Linkage Group IV

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Glucose-6-phosphate isomerasePRO_0000180576Add
    BLAST

    Proteomic databases

    PRIDEiQ7S986.

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU07281.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7S986.
    SMRiQ7S986. Positions 4-559.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiISIYESN.
    OrthoDBiEOG7N0CDV.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7S986-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPANTLSAW SDLQSHHSKV GKTFVLKDAF KSDPERFSKF ARTFTLPADI    50
    SSDSPNATDI LFDFSKNLVT EETLDKLVRL AEEAGVEKKR DAMFAGEKIN 100
    FTEDRAVYHV ALRNVSNQEM KVDGVDVMNT KGGVNEVLQH MKEFSEQVRS 150
    GEWKGYTGKK LTNIINIGIG GSDLGPVMVT EALKHYGAKD MTLRFVSNVD 200
    GTHIAEALAA SDPETTLFLI ASKTFTTAET ITNANTAKSW FLEKTGGQGD 250
    ITKHFVALST NEAEVTKFGI DAKNMFGFES WVGGRYSVWS AIGLSVALYV 300
    GYENFHKFLA GAHAMDNHFR TAPLKENIPV LGGILSVWYS NFYNAQTHLI 350
    APFDQYLHRF PAYLQQLSME SNGKSITSDG SAAKYTTGPI VFGEPCTNAQ 400
    HSFFQLVHQG TKLIPADFIL AAKSHNPISN NLHQKMLASN YLAQAEALMV 450
    GKTAEEVRAE GNVPEHLVPH KVFLGNRPTT SILVGGHIGP AELGALIVYY 500
    EHLTFTEGAI WDINSFDQWG VELGKVLAKK ILKEIDEPGA GSGHDASTGG 550
    LLGAFKKYAD F 561
    Length:561
    Mass (Da):61,398
    Last modified:December 15, 2003 - v1
    Checksum:iF21908EC4F38884C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002239 Genomic DNA. Translation: EAA32899.1.
    RefSeqiXP_962135.1. XM_957042.2.
    UniGeneiNcr.11301.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000007110; EFNCRP00000007100; EFNCRG00000007098.
    GeneIDi3878284.
    KEGGincr:NCU07281.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002239 Genomic DNA. Translation: EAA32899.1 .
    RefSeqi XP_962135.1. XM_957042.2.
    UniGenei Ncr.11301.

    3D structure databases

    ProteinModelPortali Q7S986.
    SMRi Q7S986. Positions 4-559.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU07281.1.

    Proteomic databases

    PRIDEi Q7S986.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000007110 ; EFNCRP00000007100 ; EFNCRG00000007098 .
    GeneIDi 3878284.
    KEGGi ncr:NCU07281.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi ISIYESN.
    OrthoDBi EOG7N0CDV.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiG6PI_NEUCR
    AccessioniPrimary (citable) accession number: Q7S986
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3