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Q7S986

- G6PI_NEUCR

UniProt

Q7S986 - G6PI_NEUCR

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Protein

Glucose-6-phosphate isomerase

Gene

pgi-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei370 – 3701Proton donorBy similarity
Active sitei401 – 4011By similarity
Active sitei525 – 5251By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi-1
Synonyms:emp-2, gpi-1
ORF Names:NCU07281
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 4, Linkage Group IV

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Glucose-6-phosphate isomerasePRO_0000180576Add
BLAST

Proteomic databases

PRIDEiQ7S986.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU07281.1.

Structurei

3D structure databases

ProteinModelPortaliQ7S986.
SMRiQ7S986. Positions 4-559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
InParanoidiQ7S986.
KOiK01810.
OMAiISIYESN.
OrthoDBiEOG7N0CDV.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7S986-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPANTLSAW SDLQSHHSKV GKTFVLKDAF KSDPERFSKF ARTFTLPADI
60 70 80 90 100
SSDSPNATDI LFDFSKNLVT EETLDKLVRL AEEAGVEKKR DAMFAGEKIN
110 120 130 140 150
FTEDRAVYHV ALRNVSNQEM KVDGVDVMNT KGGVNEVLQH MKEFSEQVRS
160 170 180 190 200
GEWKGYTGKK LTNIINIGIG GSDLGPVMVT EALKHYGAKD MTLRFVSNVD
210 220 230 240 250
GTHIAEALAA SDPETTLFLI ASKTFTTAET ITNANTAKSW FLEKTGGQGD
260 270 280 290 300
ITKHFVALST NEAEVTKFGI DAKNMFGFES WVGGRYSVWS AIGLSVALYV
310 320 330 340 350
GYENFHKFLA GAHAMDNHFR TAPLKENIPV LGGILSVWYS NFYNAQTHLI
360 370 380 390 400
APFDQYLHRF PAYLQQLSME SNGKSITSDG SAAKYTTGPI VFGEPCTNAQ
410 420 430 440 450
HSFFQLVHQG TKLIPADFIL AAKSHNPISN NLHQKMLASN YLAQAEALMV
460 470 480 490 500
GKTAEEVRAE GNVPEHLVPH KVFLGNRPTT SILVGGHIGP AELGALIVYY
510 520 530 540 550
EHLTFTEGAI WDINSFDQWG VELGKVLAKK ILKEIDEPGA GSGHDASTGG
560
LLGAFKKYAD F
Length:561
Mass (Da):61,398
Last modified:December 15, 2003 - v1
Checksum:iF21908EC4F38884C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002239 Genomic DNA. Translation: EAA32899.1.
RefSeqiXP_962135.1. XM_957042.2.
UniGeneiNcr.11301.

Genome annotation databases

EnsemblFungiiEFNCRT00000007110; EFNCRP00000007100; EFNCRG00000007098.
GeneIDi3878284.
KEGGincr:NCU07281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002239 Genomic DNA. Translation: EAA32899.1 .
RefSeqi XP_962135.1. XM_957042.2.
UniGenei Ncr.11301.

3D structure databases

ProteinModelPortali Q7S986.
SMRi Q7S986. Positions 4-559.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU07281.1.

Proteomic databases

PRIDEi Q7S986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000007110 ; EFNCRP00000007100 ; EFNCRG00000007098 .
GeneIDi 3878284.
KEGGi ncr:NCU07281.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261371.
InParanoidi Q7S986.
KOi K01810.
OMAi ISIYESN.
OrthoDBi EOG7N0CDV.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiG6PI_NEUCR
AccessioniPrimary (citable) accession number: Q7S986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3