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Q7S8J1

- NTE1_NEUCR

UniProt

Q7S8J1 - NTE1_NEUCR

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Protein

Lysophospholipase nte1

Gene
nte1, NCU08276
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1245 – 12451 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi670 – 789120cNMP 1Add
BLAST
Nucleotide bindingi835 – 955121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:NCU08276
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 4, Linkage Group IV

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959Cytoplasmic By similarityAdd
BLAST
Transmembranei60 – 8021Helical; Reviewed predictionAdd
BLAST
Topological domaini81 – 10222Lumenal By similarityAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Topological domaini124 – 15151392Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15151515Lysophospholipase nte1PRO_0000295326Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU08276.1.

Structurei

3D structure databases

ProteinModelPortaliQ7S8J1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1212 – 1376165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1243 – 12475GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 2856Poly-Asp

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7S8J1-1 [UniParc]FASTAAdd to Basket

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MESLSNLGNA MSSVLSETTS TTATAILADP TEALSSVVAL ASDAVSKATS     50
DVVPEHTPTS WFTIILWLLH RISSVLYFVI KLTTITTPTF LFNIFSTSLT 100
VTMNATTLVL IMLFMMAGVT WVVRYRYLNM YSRLPPEPQR KEPAVDLFPE 150
TQEEGVKSGL ASYFDEFLSA IKIFGYLERP VFHELTRSMQ TRKLIAGETL 200
NLEEEQGFCL VVDGMVEIFV KSARDGRRSS SGPSFESDDE EGFAPGRQRY 250
QLLTEVRNGA PMSSLFSIMS LFTEDIQMHD TDDDDSPDPT PSAPGTAMPG 300
YPMNANFQQS NDTLPSIPGT PLSDNHVMQR GMASAESLTM SPLAHDSSRI 350
PSLSLVNTRP AVPRRPVPKR LNTTSAHPDI IARATVDTTI AIIPASAFRR 400
LIKIYPKATA HIVHVILSRF QRVTLATAYN YLGLSGEVLQ MERNILKHTV 450
RQLPNHLRGD ALDRLKEKFK RERERIGEKE VEKGIALHNA HAARRRRSAA 500
SLRKEVALQA YSKRRQSIVT ATPAFGTRRE RPSPDMPSPG DLLTNTQQLK 550
SGPASQLDLA RDATSPRPQR NLSPFSTPRN AHVSLDTREA LDEDDMFRES 600
VLECMFRAIG LTGNGSVNPD STQASPRFVP TDQRRSRGGP GHTAFGFMDA 650
FDPFDNDTES VTSCGFSSSS PVPNPQLLAH DMKDEVEIVF FPKGSVLVEQ 700
GERNPGLYYV IDGFLDICVP GDDSSHDLLQ SSAKVDHGHD SATGADAFGA 750
NSSRFPEPNM NNNFGAEQKK GKQGRRSVAL IKPGGLAGYV GTISSYRSFI 800
DVVARTDVCV GFLPLASIDR IVDRYPIVML TMAKRLTELL PRLLLHIDFA 850
LEWVQVNSGQ VLFREGDESE AIYLVLNGRL RLVEDQKDGG MNVKAEFGQG 900
ESIGELEVLT ESARTGTLHA IRETELVKFP RTLFNSLAQE HPNITIKISK 950
IIAARMRAFI DDPSRMGLKD NVVRSYKSSS TLNLRTVAIL PVTAGVPVVE 1000
FGNRLMNALS QVGPPNGATC LNQAAILNHL GKLAFNRMGK LKLSQYLADL 1050
EEKYGLVVYV ADTNVNTPWT QTCITQADCL LFVGLADSSP EIGEYERFML 1100
GMKSTARKIL VLVHQERYSN PGLTRQWLKN RMWINGGHFH VQMAYTSNTV 1150
PIHPPTKRFG PSLKQRVQIL QAEIQKYTSR KVRHVPFYSP DAPFKGDFHR 1200
LARRLCGKSV GLVLGGGGAR GIAHVGIIRA MEEAGIPIDM VGGTSIGAFI 1250
GGLYARHADV VPIFGLAKKF AGRMASMWRF AFDLTYPSAS YTTGHEFNRG 1300
IFKTFGKTQI EDFWLEYYCN TTNISKSRVE FHTSGYAWRY IRASMSLAGL 1350
LPPLCDEGSM LLDGGYIDNL TVSRMKSLGS DVIFAVDVGS LDDNTPQAFG 1400
DSLSGVWAFF NRWNPFSSVP NPPTLAEIQA RLAYVSSVGE LERAKTMPGC 1450
IYMRPPIDDY GTLDFGKFDE IYGVGYKYGQ EFLQKLREQG VLPLVEETEA 1500
KKALRRTMAP RRASI 1515
Length:1,515
Mass (Da):167,560
Last modified:July 24, 2007 - v2
Checksum:iBB4572D40BEB6275
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002239 Genomic DNA. Translation: EAA32668.3.
RefSeqiXP_961904.2. XM_956811.2.
UniGeneiNcr.12296.

Genome annotation databases

EnsemblFungiiEFNCRT00000008445; EFNCRP00000008431; EFNCRG00000008431.
GeneIDi3878043.
KEGGincr:NCU08276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002239 Genomic DNA. Translation: EAA32668.3 .
RefSeqi XP_961904.2. XM_956811.2.
UniGenei Ncr.12296.

3D structure databases

ProteinModelPortali Q7S8J1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU08276.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000008445 ; EFNCRP00000008431 ; EFNCRG00000008431 .
GeneIDi 3878043.
KEGGi ncr:NCU08276.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiNTE1_NEUCR
AccessioniPrimary (citable) accession number: Q7S8J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: March 19, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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