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Q7S8J1 (NTE1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase nte1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:NCU08276
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length1515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15151515Lysophospholipase nte1
PRO_0000295326

Regions

Topological domain1 – 5959Cytoplasmic By similarity
Transmembrane60 – 8021Helical; Potential
Topological domain81 – 10222Lumenal By similarity
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 15151392Cytoplasmic By similarity
Domain1212 – 1376165Patatin
Nucleotide binding670 – 789120cNMP 1
Nucleotide binding835 – 955121cNMP 2
Motif1243 – 12475GXSXG
Compositional bias280 – 2856Poly-Asp

Sites

Active site12451 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7S8J1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: BB4572D40BEB6275

FASTA1,515167,560
        10         20         30         40         50         60 
MESLSNLGNA MSSVLSETTS TTATAILADP TEALSSVVAL ASDAVSKATS DVVPEHTPTS 

        70         80         90        100        110        120 
WFTIILWLLH RISSVLYFVI KLTTITTPTF LFNIFSTSLT VTMNATTLVL IMLFMMAGVT 

       130        140        150        160        170        180 
WVVRYRYLNM YSRLPPEPQR KEPAVDLFPE TQEEGVKSGL ASYFDEFLSA IKIFGYLERP 

       190        200        210        220        230        240 
VFHELTRSMQ TRKLIAGETL NLEEEQGFCL VVDGMVEIFV KSARDGRRSS SGPSFESDDE 

       250        260        270        280        290        300 
EGFAPGRQRY QLLTEVRNGA PMSSLFSIMS LFTEDIQMHD TDDDDSPDPT PSAPGTAMPG 

       310        320        330        340        350        360 
YPMNANFQQS NDTLPSIPGT PLSDNHVMQR GMASAESLTM SPLAHDSSRI PSLSLVNTRP 

       370        380        390        400        410        420 
AVPRRPVPKR LNTTSAHPDI IARATVDTTI AIIPASAFRR LIKIYPKATA HIVHVILSRF 

       430        440        450        460        470        480 
QRVTLATAYN YLGLSGEVLQ MERNILKHTV RQLPNHLRGD ALDRLKEKFK RERERIGEKE 

       490        500        510        520        530        540 
VEKGIALHNA HAARRRRSAA SLRKEVALQA YSKRRQSIVT ATPAFGTRRE RPSPDMPSPG 

       550        560        570        580        590        600 
DLLTNTQQLK SGPASQLDLA RDATSPRPQR NLSPFSTPRN AHVSLDTREA LDEDDMFRES 

       610        620        630        640        650        660 
VLECMFRAIG LTGNGSVNPD STQASPRFVP TDQRRSRGGP GHTAFGFMDA FDPFDNDTES 

       670        680        690        700        710        720 
VTSCGFSSSS PVPNPQLLAH DMKDEVEIVF FPKGSVLVEQ GERNPGLYYV IDGFLDICVP 

       730        740        750        760        770        780 
GDDSSHDLLQ SSAKVDHGHD SATGADAFGA NSSRFPEPNM NNNFGAEQKK GKQGRRSVAL 

       790        800        810        820        830        840 
IKPGGLAGYV GTISSYRSFI DVVARTDVCV GFLPLASIDR IVDRYPIVML TMAKRLTELL 

       850        860        870        880        890        900 
PRLLLHIDFA LEWVQVNSGQ VLFREGDESE AIYLVLNGRL RLVEDQKDGG MNVKAEFGQG 

       910        920        930        940        950        960 
ESIGELEVLT ESARTGTLHA IRETELVKFP RTLFNSLAQE HPNITIKISK IIAARMRAFI 

       970        980        990       1000       1010       1020 
DDPSRMGLKD NVVRSYKSSS TLNLRTVAIL PVTAGVPVVE FGNRLMNALS QVGPPNGATC 

      1030       1040       1050       1060       1070       1080 
LNQAAILNHL GKLAFNRMGK LKLSQYLADL EEKYGLVVYV ADTNVNTPWT QTCITQADCL 

      1090       1100       1110       1120       1130       1140 
LFVGLADSSP EIGEYERFML GMKSTARKIL VLVHQERYSN PGLTRQWLKN RMWINGGHFH 

      1150       1160       1170       1180       1190       1200 
VQMAYTSNTV PIHPPTKRFG PSLKQRVQIL QAEIQKYTSR KVRHVPFYSP DAPFKGDFHR 

      1210       1220       1230       1240       1250       1260 
LARRLCGKSV GLVLGGGGAR GIAHVGIIRA MEEAGIPIDM VGGTSIGAFI GGLYARHADV 

      1270       1280       1290       1300       1310       1320 
VPIFGLAKKF AGRMASMWRF AFDLTYPSAS YTTGHEFNRG IFKTFGKTQI EDFWLEYYCN 

      1330       1340       1350       1360       1370       1380 
TTNISKSRVE FHTSGYAWRY IRASMSLAGL LPPLCDEGSM LLDGGYIDNL TVSRMKSLGS 

      1390       1400       1410       1420       1430       1440 
DVIFAVDVGS LDDNTPQAFG DSLSGVWAFF NRWNPFSSVP NPPTLAEIQA RLAYVSSVGE 

      1450       1460       1470       1480       1490       1500 
LERAKTMPGC IYMRPPIDDY GTLDFGKFDE IYGVGYKYGQ EFLQKLREQG VLPLVEETEA 

      1510 
KKALRRTMAP RRASI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002239 Genomic DNA. Translation: EAA32668.3.
RefSeqXP_961904.2. XM_956811.2.
UniGeneNcr.12296.

3D structure databases

ProteinModelPortalQ7S8J1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU08276.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000008445; EFNCRP00000008431; EFNCRG00000008431.
GeneID3878043.
KEGGncr:NCU08276.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_NEUCR
AccessionPrimary (citable) accession number: Q7S8J1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: March 19, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families