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Q7S8J1

- NTE1_NEUCR

UniProt

Q7S8J1 - NTE1_NEUCR

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1245 – 12451By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi670 – 789120cNMP 1Add
    BLAST
    Nucleotide bindingi835 – 955121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase nte1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:NCU08276
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 4, Linkage Group IV

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15151515Lysophospholipase nte1PRO_0000295326Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU08276.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7S8J1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5959CytoplasmicBy similarityAdd
    BLAST
    Topological domaini81 – 10222LumenalBy similarityAdd
    BLAST
    Topological domaini124 – 15151392CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1212 – 1376165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1243 – 12475GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi280 – 2856Poly-Asp

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7S8J1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLSNLGNA MSSVLSETTS TTATAILADP TEALSSVVAL ASDAVSKATS     50
    DVVPEHTPTS WFTIILWLLH RISSVLYFVI KLTTITTPTF LFNIFSTSLT 100
    VTMNATTLVL IMLFMMAGVT WVVRYRYLNM YSRLPPEPQR KEPAVDLFPE 150
    TQEEGVKSGL ASYFDEFLSA IKIFGYLERP VFHELTRSMQ TRKLIAGETL 200
    NLEEEQGFCL VVDGMVEIFV KSARDGRRSS SGPSFESDDE EGFAPGRQRY 250
    QLLTEVRNGA PMSSLFSIMS LFTEDIQMHD TDDDDSPDPT PSAPGTAMPG 300
    YPMNANFQQS NDTLPSIPGT PLSDNHVMQR GMASAESLTM SPLAHDSSRI 350
    PSLSLVNTRP AVPRRPVPKR LNTTSAHPDI IARATVDTTI AIIPASAFRR 400
    LIKIYPKATA HIVHVILSRF QRVTLATAYN YLGLSGEVLQ MERNILKHTV 450
    RQLPNHLRGD ALDRLKEKFK RERERIGEKE VEKGIALHNA HAARRRRSAA 500
    SLRKEVALQA YSKRRQSIVT ATPAFGTRRE RPSPDMPSPG DLLTNTQQLK 550
    SGPASQLDLA RDATSPRPQR NLSPFSTPRN AHVSLDTREA LDEDDMFRES 600
    VLECMFRAIG LTGNGSVNPD STQASPRFVP TDQRRSRGGP GHTAFGFMDA 650
    FDPFDNDTES VTSCGFSSSS PVPNPQLLAH DMKDEVEIVF FPKGSVLVEQ 700
    GERNPGLYYV IDGFLDICVP GDDSSHDLLQ SSAKVDHGHD SATGADAFGA 750
    NSSRFPEPNM NNNFGAEQKK GKQGRRSVAL IKPGGLAGYV GTISSYRSFI 800
    DVVARTDVCV GFLPLASIDR IVDRYPIVML TMAKRLTELL PRLLLHIDFA 850
    LEWVQVNSGQ VLFREGDESE AIYLVLNGRL RLVEDQKDGG MNVKAEFGQG 900
    ESIGELEVLT ESARTGTLHA IRETELVKFP RTLFNSLAQE HPNITIKISK 950
    IIAARMRAFI DDPSRMGLKD NVVRSYKSSS TLNLRTVAIL PVTAGVPVVE 1000
    FGNRLMNALS QVGPPNGATC LNQAAILNHL GKLAFNRMGK LKLSQYLADL 1050
    EEKYGLVVYV ADTNVNTPWT QTCITQADCL LFVGLADSSP EIGEYERFML 1100
    GMKSTARKIL VLVHQERYSN PGLTRQWLKN RMWINGGHFH VQMAYTSNTV 1150
    PIHPPTKRFG PSLKQRVQIL QAEIQKYTSR KVRHVPFYSP DAPFKGDFHR 1200
    LARRLCGKSV GLVLGGGGAR GIAHVGIIRA MEEAGIPIDM VGGTSIGAFI 1250
    GGLYARHADV VPIFGLAKKF AGRMASMWRF AFDLTYPSAS YTTGHEFNRG 1300
    IFKTFGKTQI EDFWLEYYCN TTNISKSRVE FHTSGYAWRY IRASMSLAGL 1350
    LPPLCDEGSM LLDGGYIDNL TVSRMKSLGS DVIFAVDVGS LDDNTPQAFG 1400
    DSLSGVWAFF NRWNPFSSVP NPPTLAEIQA RLAYVSSVGE LERAKTMPGC 1450
    IYMRPPIDDY GTLDFGKFDE IYGVGYKYGQ EFLQKLREQG VLPLVEETEA 1500
    KKALRRTMAP RRASI 1515
    Length:1,515
    Mass (Da):167,560
    Last modified:July 24, 2007 - v2
    Checksum:iBB4572D40BEB6275
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002239 Genomic DNA. Translation: EAA32668.3.
    RefSeqiXP_961904.2. XM_956811.2.
    UniGeneiNcr.12296.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000008445; EFNCRP00000008431; EFNCRG00000008431.
    GeneIDi3878043.
    KEGGincr:NCU08276.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002239 Genomic DNA. Translation: EAA32668.3 .
    RefSeqi XP_961904.2. XM_956811.2.
    UniGenei Ncr.12296.

    3D structure databases

    ProteinModelPortali Q7S8J1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU08276.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000008445 ; EFNCRP00000008431 ; EFNCRG00000008431 .
    GeneIDi 3878043.
    KEGGi ncr:NCU08276.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiNTE1_NEUCR
    AccessioniPrimary (citable) accession number: Q7S8J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3