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Q7S8J1

- NTE1_NEUCR

UniProt

Q7S8J1 - NTE1_NEUCR

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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1245 – 12451By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi670 – 789120cNMP 1Add
BLAST
Nucleotide bindingi835 – 955121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:NCU08276
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 4, Linkage Group IV

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15151515Lysophospholipase nte1PRO_0000295326Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU08276.1.

Structurei

3D structure databases

ProteinModelPortaliQ7S8J1.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959CytoplasmicBy similarityAdd
BLAST
Topological domaini81 – 10222LumenalBy similarityAdd
BLAST
Topological domaini124 – 15151392CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1212 – 1376165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1243 – 12475GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 2856Poly-Asp

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ7S8J1.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7S8J1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESLSNLGNA MSSVLSETTS TTATAILADP TEALSSVVAL ASDAVSKATS
60 70 80 90 100
DVVPEHTPTS WFTIILWLLH RISSVLYFVI KLTTITTPTF LFNIFSTSLT
110 120 130 140 150
VTMNATTLVL IMLFMMAGVT WVVRYRYLNM YSRLPPEPQR KEPAVDLFPE
160 170 180 190 200
TQEEGVKSGL ASYFDEFLSA IKIFGYLERP VFHELTRSMQ TRKLIAGETL
210 220 230 240 250
NLEEEQGFCL VVDGMVEIFV KSARDGRRSS SGPSFESDDE EGFAPGRQRY
260 270 280 290 300
QLLTEVRNGA PMSSLFSIMS LFTEDIQMHD TDDDDSPDPT PSAPGTAMPG
310 320 330 340 350
YPMNANFQQS NDTLPSIPGT PLSDNHVMQR GMASAESLTM SPLAHDSSRI
360 370 380 390 400
PSLSLVNTRP AVPRRPVPKR LNTTSAHPDI IARATVDTTI AIIPASAFRR
410 420 430 440 450
LIKIYPKATA HIVHVILSRF QRVTLATAYN YLGLSGEVLQ MERNILKHTV
460 470 480 490 500
RQLPNHLRGD ALDRLKEKFK RERERIGEKE VEKGIALHNA HAARRRRSAA
510 520 530 540 550
SLRKEVALQA YSKRRQSIVT ATPAFGTRRE RPSPDMPSPG DLLTNTQQLK
560 570 580 590 600
SGPASQLDLA RDATSPRPQR NLSPFSTPRN AHVSLDTREA LDEDDMFRES
610 620 630 640 650
VLECMFRAIG LTGNGSVNPD STQASPRFVP TDQRRSRGGP GHTAFGFMDA
660 670 680 690 700
FDPFDNDTES VTSCGFSSSS PVPNPQLLAH DMKDEVEIVF FPKGSVLVEQ
710 720 730 740 750
GERNPGLYYV IDGFLDICVP GDDSSHDLLQ SSAKVDHGHD SATGADAFGA
760 770 780 790 800
NSSRFPEPNM NNNFGAEQKK GKQGRRSVAL IKPGGLAGYV GTISSYRSFI
810 820 830 840 850
DVVARTDVCV GFLPLASIDR IVDRYPIVML TMAKRLTELL PRLLLHIDFA
860 870 880 890 900
LEWVQVNSGQ VLFREGDESE AIYLVLNGRL RLVEDQKDGG MNVKAEFGQG
910 920 930 940 950
ESIGELEVLT ESARTGTLHA IRETELVKFP RTLFNSLAQE HPNITIKISK
960 970 980 990 1000
IIAARMRAFI DDPSRMGLKD NVVRSYKSSS TLNLRTVAIL PVTAGVPVVE
1010 1020 1030 1040 1050
FGNRLMNALS QVGPPNGATC LNQAAILNHL GKLAFNRMGK LKLSQYLADL
1060 1070 1080 1090 1100
EEKYGLVVYV ADTNVNTPWT QTCITQADCL LFVGLADSSP EIGEYERFML
1110 1120 1130 1140 1150
GMKSTARKIL VLVHQERYSN PGLTRQWLKN RMWINGGHFH VQMAYTSNTV
1160 1170 1180 1190 1200
PIHPPTKRFG PSLKQRVQIL QAEIQKYTSR KVRHVPFYSP DAPFKGDFHR
1210 1220 1230 1240 1250
LARRLCGKSV GLVLGGGGAR GIAHVGIIRA MEEAGIPIDM VGGTSIGAFI
1260 1270 1280 1290 1300
GGLYARHADV VPIFGLAKKF AGRMASMWRF AFDLTYPSAS YTTGHEFNRG
1310 1320 1330 1340 1350
IFKTFGKTQI EDFWLEYYCN TTNISKSRVE FHTSGYAWRY IRASMSLAGL
1360 1370 1380 1390 1400
LPPLCDEGSM LLDGGYIDNL TVSRMKSLGS DVIFAVDVGS LDDNTPQAFG
1410 1420 1430 1440 1450
DSLSGVWAFF NRWNPFSSVP NPPTLAEIQA RLAYVSSVGE LERAKTMPGC
1460 1470 1480 1490 1500
IYMRPPIDDY GTLDFGKFDE IYGVGYKYGQ EFLQKLREQG VLPLVEETEA
1510
KKALRRTMAP RRASI
Length:1,515
Mass (Da):167,560
Last modified:July 24, 2007 - v2
Checksum:iBB4572D40BEB6275
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002239 Genomic DNA. Translation: EAA32668.3.
RefSeqiXP_961904.2. XM_956811.2.
UniGeneiNcr.12296.

Genome annotation databases

EnsemblFungiiEFNCRT00000008445; EFNCRP00000008431; EFNCRG00000008431.
GeneIDi3878043.
KEGGincr:NCU08276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002239 Genomic DNA. Translation: EAA32668.3 .
RefSeqi XP_961904.2. XM_956811.2.
UniGenei Ncr.12296.

3D structure databases

ProteinModelPortali Q7S8J1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU08276.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000008445 ; EFNCRP00000008431 ; EFNCRG00000008431 .
GeneIDi 3878043.
KEGGi ncr:NCU08276.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
InParanoidi Q7S8J1.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiNTE1_NEUCR
AccessioniPrimary (citable) accession number: Q7S8J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3