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Q7S4Z6 (FDFT_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable squalene synthase

Short name=SQS
Short name=SS
EC=2.5.1.21
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene names
Name:erg-6
Synonyms:erg9
ORF Names:NCU06054
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol By similarity.

Catalytic activity

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactor

Magnesium By similarity.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Probable squalene synthase
PRO_0000067449

Regions

Transmembrane294 – 31421Helical; Potential
Transmembrane416 – 43621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7S4Z6 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 59ED6533600BF4DC

FASTA48154,942
        10         20         30         40         50         60 
MGAFTKAAYF LLHPNQLRSI VQWKVWHEPV HRRDPSKETE TEKACFRHLE LTSRSFSAVI 

        70         80         90        100        110        120 
QELNPELLMP ICLFYLVLRG LDTIEDDMTI DLAKKEPLLR EFADLMEIDG WTFTENGPNE 

       130        140        150        160        170        180 
KDRELLVHFD DVIAELKKVK KPYYDIIREI TVKMGNGMAD YALNAEHNTN GVNTIEEYEL 

       190        200        210        220        230        240 
YCHYVAGLVG EGLTRLFVES NLANPALLER MELTESMGQF LQKTNIIRDI HEDYVDKRRF 

       250        260        270        280        290        300 
WPKTIWSKYV NTWDDMFKPE NREKALQCSS EMVLNALKHT EDCLFYMAGM RDQSVFNFVA 

       310        320        330        340        350        360 
IPQAMAIATL ELVFRNPAIF ERNVKITKGD ACQLMMESTQ NLRVVCEVFR RYARRIHKKN 

       370        380        390        400        410        420 
DPRDPNYLAI SVQCGKIEQF IESIFPTQDP KKIALAQAQN SNQTAANTTD NGDTTFLVLS 

       430        440        450        460        470        480 
MIGVLFVMGG LMIGAAWLMG ARFDMAYEDI TARVGTLVNG AAAVSSATVS SIPTTVMHQE 


L 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002242 Genomic DNA. Translation: ESA41923.1.
RefSeqXP_959817.1. XM_954724.2.

3D structure databases

ProteinModelPortalQ7S4Z6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU06054.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000005379; EFNCRP00000005373; EFNCRG00000005372.
GeneID3875964.
KEGGncr:NCU06054.

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000186940.
KOK00801.
OMACLNAMVA.
OrthoDBEOG7GJ6P5.

Enzyme and pathway databases

UniPathwayUPA00767; UER00751.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_NEUCR
AccessionPrimary (citable) accession number: Q7S4Z6
Secondary accession number(s): V5IKD8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways