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Protein

Probable squalene synthase

Gene

erg-6

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity).By similarity

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Mg2+By similarity

Pathwayi: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable squalene synthase (erg-6)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processIsoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandMagnesium, NADP

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751

Names & Taxonomyi

Protein namesi
Recommended name:
Probable squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene namesi
Name:erg-6
Synonyms:erg9
ORF Names:NCU06054
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBiFungiDB:NCU06054

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674491 – 481Probable squalene synthaseAdd BLAST481

Structurei

3D structure databases

ProteinModelPortaliQ7S4Z6
SMRiQ7S4Z6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000186940
InParanoidiQ7S4Z6
KOiK00801
OMAiFNFVAIP
OrthoDBiEOG092C2IU6

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR006449 Squal_synth-like
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR01559 squal_synth, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7S4Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAFTKAAYF LLHPNQLRSI VQWKVWHEPV HRRDPSKETE TEKACFRHLE
60 70 80 90 100
LTSRSFSAVI QELNPELLMP ICLFYLVLRG LDTIEDDMTI DLAKKEPLLR
110 120 130 140 150
EFADLMEIDG WTFTENGPNE KDRELLVHFD DVIAELKKVK KPYYDIIREI
160 170 180 190 200
TVKMGNGMAD YALNAEHNTN GVNTIEEYEL YCHYVAGLVG EGLTRLFVES
210 220 230 240 250
NLANPALLER MELTESMGQF LQKTNIIRDI HEDYVDKRRF WPKTIWSKYV
260 270 280 290 300
NTWDDMFKPE NREKALQCSS EMVLNALKHT EDCLFYMAGM RDQSVFNFVA
310 320 330 340 350
IPQAMAIATL ELVFRNPAIF ERNVKITKGD ACQLMMESTQ NLRVVCEVFR
360 370 380 390 400
RYARRIHKKN DPRDPNYLAI SVQCGKIEQF IESIFPTQDP KKIALAQAQN
410 420 430 440 450
SNQTAANTTD NGDTTFLVLS MIGVLFVMGG LMIGAAWLMG ARFDMAYEDI
460 470 480
TARVGTLVNG AAAVSSATVS SIPTTVMHQE L
Length:481
Mass (Da):54,942
Last modified:December 15, 2003 - v1
Checksum:i59ED6533600BF4DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002242 Genomic DNA Translation: ESA41923.1
RefSeqiXP_011395225.1, XM_011396923.1

Genome annotation databases

EnsemblFungiiESA41923; ESA41923; NCU06054
GeneIDi3875964
KEGGincr:NCU06054

Similar proteinsi

Entry informationi

Entry nameiFDFT_NEUCR
AccessioniPrimary (citable) accession number: Q7S4Z6
Secondary accession number(s): V5IKD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 15, 2003
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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